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1.发明授权Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权二氢吲哚酮化合物，其制备方法和含有它们的药物组合物公开(公告)号：US08653073B2
公开(公告)日：2014-02-18
申请号：US13772984
申请日：2013-02-21
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burnbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。
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2.发明申请DIHYDROINDOLONE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权二氢吲哚酮化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20130331380A1
公开(公告)日：2013-12-12
申请号：US13772984
申请日：2013-02-21
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： C07D417/14 , C07D403/14 , C07D413/14
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。
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公开(公告)号：US20120046287A1
公开(公告)日：2012-02-23
申请号：US13373016
申请日：2011-11-02
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes
IPC分类号： A61K31/5377 , A61K31/445 , A61P35/04 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
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4.发明授权Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权二氢吲哚酮化合物，其制备方法和含有它们的药物组合物公开(公告)号：US08541412B2
公开(公告)日：2013-09-24
申请号：US13373016
申请日：2011-11-02
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/404
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。
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5.发明授权Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权二氢吲哚酮化合物，其制备方法和含有它们的药物组合物公开(公告)号：US08133889B2
公开(公告)日：2012-03-13
申请号：US12806045
申请日：2010-08-04
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste, legal representative , Pauline Lacoste, legal representative , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , A61K31/422 , A61K31/496 , A61K31/454 , C07D413/14 , A61P35/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。
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6.发明申请Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them 有权二氢吲哚酮化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20110034460A1
公开(公告)日：2011-02-10
申请号：US12806045
申请日：2010-08-04
申请人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
发明人： Jean-Claude Ortuno , Alexis Cordi , Jean-Michel Lacoste , Vincent Lacoste , Pauline Lacoste , Imre Fejes , Michael Burbridge , John Hickman , Alain Pierre
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/422 , A61K31/496 , A61K31/454 , A61P35/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Compounds of formula (I): wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO2 group, R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, R3 and R4, together with the atoms carrying them, form a heterocyclic group, R5 represents a hydrogen atom or an alkyl group, R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.
摘要翻译： 式（I）化合物：其中：m和n表示1或2，A表示吡咯基，X表示C（O），S（O）或SO 2基团，R 1和R 2表示烷基， 与它们携带的氮原子一起形成杂环基，R3和R4与携带它们的原子一起形成杂环基，R 5表示氢原子或烷基，R 6表示氢原子或卤素原子。 含有该药物的药物可用于治疗癌症。
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7.发明授权公开(公告)号：US10688101B2
公开(公告)日：2020-06-23
申请号：US16271171
申请日：2019-02-08
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US10689364B2
公开(公告)日：2020-06-23
申请号：US15704330
申请日：2017-09-14
发明人： James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Claire Walmsley , Mark Dodsworth , Johannes W. G. Meissner , Paul Brough , Imre Fejes , János Tatai , Miklós Nyerges , András Kotschy , Zoltán Szlávik , Olivier Geneste , Arnaud Le Tiran , Thierry Le Diguarher , Jean-Michel Henlin , Jérôme-Benoît Starck , Anne-Françoise Guillouzic , Guillaume De Nanteuil
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4725 , C07D409/14 , C07D471/04 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D417/14 , C07F9/6561
摘要： Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p′, q, and q′ are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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公开(公告)号：US11058689B2
公开(公告)日：2021-07-13
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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10.发明授权公开(公告)号：US10265323B2
公开(公告)日：2019-04-23
申请号：US15419228
申请日：2017-01-30
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K45/06 , A61K31/496 , A61K31/506 , C07D401/10 , C07D401/14 , C07D405/14 , A61K31/4725 , A61K31/5377 , A61K31/5383 , C07D471/04 , C07D491/10 , C07D498/04 , C07D491/107 , C07D498/14 , A61K9/20
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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