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公开(公告)号:US08592594B2
公开(公告)日:2013-11-26
申请号:US13169097
申请日:2011-06-27
申请人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
发明人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
IPC分类号: C07D215/38
CPC分类号: C07D215/48 , C07D401/06 , C07D405/12 , C07D471/04
摘要: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
摘要翻译: 式(I)化合物或其药学上可接受的盐或酯,其中A1至A3和R1至R10具有权利要求1中给出的含义,可用作药物。 这些化合物可用于治疗或预防与AMPK调节相关的疾病,例如肥胖症,血脂异常,高血糖症,1型或2型糖尿病和癌症。
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公开(公告)号:US20120004218A1
公开(公告)日:2012-01-05
申请号:US13169097
申请日:2011-06-27
申请人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
发明人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
IPC分类号: A61K31/541 , C07D215/48 , C07D413/10 , C07D401/10 , C07D471/04 , C07D405/10 , C07D417/14 , A61K31/4747 , A61K31/47 , A61K31/5377 , A61K31/496 , A61K31/4375 , A61P3/04 , A61P3/10 , A61P35/00 , A61P3/06 , C07D221/20
CPC分类号: C07D215/48 , C07D401/06 , C07D405/12 , C07D471/04
摘要: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
摘要翻译: 式(I)化合物或其药学上可接受的盐或酯,其中A1至A3和R1至R10具有权利要求1中给出的含义,可用作药物。 这些化合物可用于治疗或预防与AMPK调节相关的疾病,例如肥胖症,血脂异常,高血糖症,1型或2型糖尿病和癌症。
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公开(公告)号:US08354443B2
公开(公告)日:2013-01-15
申请号:US12959408
申请日:2010-12-03
申请人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
发明人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
IPC分类号: A61K31/404 , C07D209/96
CPC分类号: C07D209/96 , C07D209/34 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D413/12 , C07D491/107
摘要: The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R1至R4具有权利要求1中给出的含义。该化合物可用于例如治疗或预防肥胖症,高血糖症 ,血脂异常和1型或2型糖尿病。
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公开(公告)号:US20110144106A1
公开(公告)日:2011-06-16
申请号:US12959408
申请日:2010-12-03
申请人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
发明人: Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
IPC分类号: A61K31/5377 , C07D209/96 , C07D401/08 , C07D403/10 , C07D413/10 , C07D401/14 , C07D403/12 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D403/04 , A61K31/403 , A61K31/4439 , A61K31/496 , A61K31/4155 , A61K31/4178 , A61K31/422
CPC分类号: C07D209/96 , C07D209/34 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D413/12 , C07D491/107
摘要: The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes,
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R1至R4具有权利要求1中给出的含义。该化合物可用于例如治疗或预防肥胖症,高血糖症 ,血脂异常和1型或2型糖尿病,
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公开(公告)号:US08268870B2
公开(公告)日:2012-09-18
申请号:US13324650
申请日:2011-12-13
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号: A61K31/4439 , C07D401/12
CPC分类号: C07D231/56 , C07D401/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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公开(公告)号:US08138208B2
公开(公告)日:2012-03-20
申请号:US12497807
申请日:2009-07-06
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号: A61K31/4439 , A61K31/416 , C07D231/54 , C07D401/02
CPC分类号: C07D231/56 , C07D401/12 , C07D413/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,W,X,R 1 -R 5和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号:US20120095053A1
公开(公告)日:2012-04-19
申请号:US13324650
申请日:2011-12-13
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号: A61K31/4439 , C07D401/12 , A61P11/06 , C07D405/14
CPC分类号: C07D231/56 , C07D401/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,R 1 -R 3和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号:US20100016369A1
公开(公告)日:2010-01-21
申请号:US12497807
申请日:2009-07-06
申请人: Li Chen , Fariboz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人: Li Chen , Fariboz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号: A61K31/4439 , C07D231/54 , A61K31/416 , C07D401/02
CPC分类号: C07D231/56 , C07D401/12 , C07D413/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,W,X,R 1 -R 5和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号:US20100016368A1
公开(公告)日:2010-01-21
申请号:US12497786
申请日:2009-07-06
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号: A61K31/416 , C07D231/56 , C07D401/12 , A61K31/4439
CPC分类号: C07D231/56 , C07D401/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,R 1 -R 3和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号:US08642629B2
公开(公告)日:2014-02-04
申请号:US12614485
申请日:2009-11-09
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Eric Mertz , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Eric Mertz , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号: A61K31/44 , C07D213/02
CPC分类号: C07D213/71 , C07C255/54 , C07C311/29 , C07C317/22 , C07C317/36 , C07C317/44 , C07C317/46 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D211/38 , C07D295/26 , C07D491/10
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中W,X,Y和R 1 -R 7在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂,可用于治疗与该受体相关的疾病和病症,例如哮喘。
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