公开(公告)号：US20240043794A1

公开(公告)日：2024-02-08

申请号：US18257534

申请日：2021-12-15

Applicant: Life Technologies Corporation

Inventor： Joel JESSEE ,  David KUNINGER ,  Soojung SHIN

IPC: C12N5/00 ,  C12N9/02

CPC classification number: C12N5/0037 ,  C12N9/0089 ,  C12Y115/01001 ,  C12N2501/71 ,  C12N2500/90 ,  C12N2500/38

Abstract: Provided herein, inter alia, are chemically defined components and compositions that substitute or partially substitute for albumin in cell culture media. The components and compositions may support cell cultures, protect cells, or enhance viability of cultured cells. Further provided are chemically defined culture media supplements for use in cell culture media containing albumin. The chemically defined culture media supplements may rescue cells from albumin-induced toxicity.

公开(公告)号：US20240000966A1

公开(公告)日：2024-01-04

申请号：US18344694

申请日：2023-06-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Evgenia VEROVSKAYA ,  Joel JESSEE

IPC: A61K47/69 ,  A61K47/58 ,  A61K9/127 ,  A61K39/145

CPC classification number: A61K47/6911 ,  A61K47/605 ,  A61K9/1277 ,  A61K39/145 ,  A61K2039/575

Abstract: Provided herein, are compositions, methods and kits for inducing an immune response in a subject. In aspects, a lipid composition is described, which includes at least one ionizable lipid comprising a charge (N), at least one peptide, and a nucleic acid molecule comprising a charge (P). In aspects, methods are provided for delivery of a payload to an immune cell using a lipid composition comprising at least one ionizable lipid, at least one endosomal release peptide, and a payload.