公开(公告)号：US20240263196A1

公开(公告)日：2024-08-08

申请号：US18398730

申请日：2023-12-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jian LIU ,  Neha PARAYATH ,  Evgenia VEROVSKAYA

IPC: C12N15/88 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/88 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

Abstract: Provided herein, are methods, compositions, and kits for introducing a payload to an immune cell. In aspects, a lipid composition is described, which includes at least one ionizable lipid compound having the structure I. In aspects, the methods and compositions are for introducing a nucleic acid payload into immune cells, for example T cells, dendritic cells, and NK cells.

公开(公告)号：US20240000966A1

公开(公告)日：2024-01-04

申请号：US18344694

申请日：2023-06-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Evgenia VEROVSKAYA ,  Joel JESSEE

IPC: A61K47/69 ,  A61K47/58 ,  A61K9/127 ,  A61K39/145

CPC classification number: A61K47/6911 ,  A61K47/605 ,  A61K9/1277 ,  A61K39/145 ,  A61K2039/575

Abstract: Provided herein, are compositions, methods and kits for inducing an immune response in a subject. In aspects, a lipid composition is described, which includes at least one ionizable lipid comprising a charge (N), at least one peptide, and a nucleic acid molecule comprising a charge (P). In aspects, methods are provided for delivery of a payload to an immune cell using a lipid composition comprising at least one ionizable lipid, at least one endosomal release peptide, and a payload.