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公开(公告)号：US09797909B2
公开(公告)日：2017-10-24
申请号：US15276428
申请日：2016-09-26
IPC分类号： G01N33/66 , G01N33/542 , G01N33/84 , G01N21/64 , G01N21/77 , A61B5/145 , A61B5/1459 , A61B5/1473 , G01N33/543
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
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公开(公告)号：US08940542B2
公开(公告)日：2015-01-27
申请号：US14048364
申请日：2013-10-08
IPC分类号： G01N33/66 , G01N21/64 , A61B5/145 , G01N21/77 , A61B5/1459 , A61B5/1473 , G01N33/84
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
摘要翻译： 一种用于检测和/或定量样品中分析物的量的传感器，所述传感器包括：感测区域; 以及包含活性氧（ROS）淬火的阻隔层，具有吸附在膜上的ROS猝灭剂的分析物可渗透膜; 其中所述传感器适于使得所述样品通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：US20170202489A1
公开(公告)日：2017-07-20
申请号：US15115967
申请日：2015-02-03
IPC分类号： A61B5/1495 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1459 , A61B2560/0233
摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.
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公开(公告)号：US20140234982A1
公开(公告)日：2014-08-21
申请号：US14048364
申请日：2013-10-08
IPC分类号： G01N21/64
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
摘要翻译： 一种用于检测和/或定量样品中分析物的量的传感器，所述传感器包括：感测区域; 以及包含活性氧（ROS）淬火的阻隔层，具有吸附在膜上的ROS猝灭剂的分析物可渗透膜; 其中所述传感器适于使得所述样品通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：US20170010274A1
公开(公告)日：2017-01-12
申请号：US15276428
申请日：2016-09-26
IPC分类号： G01N33/66 , A61B5/1473 , A61B5/145 , A61B5/1459 , G01N33/542 , G01N33/543
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
摘要翻译： 一种用于检测和/或定量样品中分析物的量的传感器，所述传感器包括：感测区域; 以及包含活性氧（ROS）淬火的阻隔层，具有吸附在膜上的ROS猝灭剂的分析物可渗透膜; 其中所述传感器适于使得所述样品通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：US20130266478A1
公开(公告)日：2013-10-10
申请号：US13686534
申请日：2012-11-27
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B2560/0223 , A61B2560/0228 , A61B2562/242 , A61L2/081 , A61L2202/24 , B01J19/00 , G01N21/278 , G01N33/50 , G01N33/66 , G01N2021/6484 , G01N2021/772 , G01N2021/775 , G01N2021/7786
摘要： A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.
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公开(公告)号：US20150219663A1
公开(公告)日：2015-08-06
申请号：US14605315
申请日：2015-01-26
IPC分类号： G01N33/66
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer.
摘要翻译： 一种用于检测和/或定量样品中分析物的量的传感器，所述传感器包括：感测区域; 以及包含活性氧（ROS）淬火的阻挡层，吸附有ROS猝灭剂的分析物可渗透膜; 其中所述传感器适于使得所述样品通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：US09017622B2
公开(公告)日：2015-04-28
申请号：US13686534
申请日：2012-11-27
IPC分类号： G01N33/50 , B01J19/00 , A61L2/08 , A61B5/145 , A61B5/1459 , A61B5/1495 , G01N21/27 , G01N21/64 , G01N21/77
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/14532 , A61B5/1459 , A61B2560/0223 , A61B2560/0228 , A61B2562/242 , A61L2/081 , A61L2202/24 , B01J19/00 , G01N21/278 , G01N33/50 , G01N33/66 , G01N2021/6484 , G01N2021/772 , G01N2021/775 , G01N2021/7786
摘要： A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.
摘要翻译： 用于校准传感器的校准器具有用于容纳校准液体的校准室。 液体包含水或待检测分析物的水溶液。 设置暴露于校准室内部的过氧化氢骤冷材料。 过氧化氢淬火材料接触校准液。 在含有校准液的校准室通过γ射线照射消毒后，过氧化氢骤冷材料分解校准液中形成的任何过氧化氢，以避免对与校准液体接触的传感器产生不利影响。
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公开(公告)号：US20130344619A1
公开(公告)日：2013-12-26
申请号：US13686760
申请日：2012-11-27
IPC分类号： G01N33/66 , A61B5/1459 , A61B5/1473 , A61B5/145
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1473 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N27/3271 , G01N2021/6432 , G01N2021/6434 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N2021/7793
摘要： A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample. A glucose sensor for carrying out a method described herein is also provided
摘要翻译： 本文提供了定量样品中葡萄糖量的方法，其可以进一步包含诸如甘露醇之类的干扰物。 使用测量方法获得至少两个测量值，这些测量方法的灵敏度与样品中干扰物的数量不同，从而使结果能够比较，以确定样品中是否存在任何干扰物。 还提供了用于执行本文所述的方法的葡萄糖传感器
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公开(公告)号：US08607612B2
公开(公告)日：2013-12-17
申请号：US13686484
申请日：2012-11-27
发明人： Nicholas Paul Barwell , Peter Edgley , Alasdair Allan Mackenzie , William Paterson , Barry Colin Crane
IPC分类号： G01K15/00 , G01N33/66 , G01N33/543
CPC分类号： G01K15/005 , G01N33/5438 , G01N33/582 , G01N33/66
摘要： A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.
摘要翻译： 校准用于检测分析物的可逆结合传感器的方法包括：（i）将第一校准溶液的温度从第一温度（T1）改变到第二温度（T2），同时第一校准溶液与 传感器的感测区域; （ii）确定作为温度的函数的第一校准溶液的传感器输出; （iii）当第二校准溶液与感测区域接触时，将第二校准溶液的温度从第三温度（T3）变化到第四温度（T4），第二校准溶液具有不同的分析物浓度 从第一个校准溶液的; （iv）确定作为温度的函数的第二校准溶液的传感器输出; 和（v）使用来自步骤（ii）和（iv）的确定的传感器输出来校准传感器。
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