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1.发明申请Coating for Medical Devices Comprising An Inorganic or Ceramic Oxide and a Therapeutic Agent 审中-公开包含无机或陶瓷氧化物和治疗剂的医疗器械的涂层公开(公告)号：US20110189377A1
公开(公告)日：2011-08-04
申请号：US13086033
申请日：2011-04-13
申请人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
发明人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
CPC分类号： A61L31/10 , A61L31/088 , A61L31/124 , A61L31/16 , A61L2300/416
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stem, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内茎，其具有包含无机或陶瓷氧化物如二氧化钛的涂层和治疗剂。
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2.发明申请Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent 审中-公开包含无机或陶瓷氧化物和治疗剂的医疗装置的涂层公开(公告)号：US20070264303A1
公开(公告)日：2007-11-15
申请号：US11433898
申请日：2006-05-12
申请人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
发明人： Liliana Atanasoska , Robert Warner , Rick Gunderson , Jan Weber , Scott Schewe
CPC分类号： A61L31/10 , A61L31/088 , A61L31/124 , A61L31/16 , A61L2300/416
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包含无机或陶瓷氧化物如二氧化钛的涂层和治疗剂。
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3.发明申请公开(公告)号：US20110046539A1
公开(公告)日：2011-02-24
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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公开(公告)号：US20060184092A1
公开(公告)日：2006-08-17
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
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5.发明授权公开(公告)号：US08152759B2
公开(公告)日：2012-04-10
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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6.发明授权公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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7.发明申请公开(公告)号：US20080262412A1
公开(公告)日：2008-10-23
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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8.发明授权公开(公告)号：US08538515B2
公开(公告)日：2013-09-17
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
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公开(公告)号：US08507639B2
公开(公告)日：2013-08-13
申请号：US11519139
申请日：2006-09-11
申请人： Liliana Atanasoska , Scott Schewe , Robert Warner
发明人： Liliana Atanasoska , Scott Schewe , Robert Warner
IPC分类号： C08G69/08
CPC分类号： A61L31/18 , A61L27/18 , A61L27/34 , A61L29/06 , A61L29/085 , A61L29/18 , A61L31/06 , A61L31/10 , C08F20/56 , C08G69/48 , C08L77/12
摘要： Radiopaque polymers have a main chain and a plurality of amide groups which have bound to the amide nitrogen atom thereof an organohalide group that is pendant to the polymer main chain, the organo halide group including one or more iodine and/or bromine atoms thereon. The polymer may be a modified polyamide polymer, copolymer or block copolymer or a modified poly(meth)acrylamide or (meth)acrylamide copolymer or block copolymer. The polymers may be employed in medical devices and are useful for instance to track the movement of a catheter through the body or the inflation of a balloon at a site. The polymers may be made by coupling reactions performed on preexisting amide polymers.
摘要翻译： 不透射线聚合物具有主链和多个与其酰胺氮原子结合的酰胺基，该有机卤化物基团垂直于聚合物主链，有机卤化物基团包括一个或多个碘和/或溴原子。 聚合物可以是改性聚酰胺聚合物，共聚物或嵌段共聚物或改性聚（甲基）丙烯酰胺或（甲基）丙烯酰胺共聚物或嵌段共聚物。 聚合物可以用于医疗装置中，并且可用于例如跟踪导管穿过身体的运动或在现场的气囊膨胀。 聚合物可以通过对预先存在的酰胺聚合物进行的偶联反应来制备。
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10.发明授权Organic-inorganic hybrid particle material and polymer compositions containing same 有权有机 - 无机杂化颗粒材料和含有它们的聚合物组合物公开(公告)号：US08008395B2
公开(公告)日：2011-08-30
申请号：US11235743
申请日：2005-09-27
CPC分类号： A61L27/427 , A61L31/124 , C08G77/458 , Y10T428/2982
摘要： Particulate materials useful as fillers, reinforcing agents, radioopacifiers, or impact modifiers. The particulate material has an average particle size range of about 10,000 nm or less and comprises an organic-inorganic hybrid material that has a ceramic material network having organic polymer segments distributed throughout the ceramic network. The ceramic network may be prepared by a sol-gel technique. The particulate material may be compounded in thermoplastic polymer compositions useful in a variety of applications such as preparation of medical device components.
摘要翻译： 可用作填料，增强剂，放射线光刻胶或抗冲改性剂的颗粒材料。 颗粒材料具有约10,000nm或更小的平均粒度范围，并且包含具有分布在整个陶瓷网络中的有机聚合物链段的陶瓷材料网络的有机 - 无机混合材料。 陶瓷网络可以通过溶胶 - 凝胶技术制备。 颗粒材料可以在可用于各种应用的热塑性聚合物组合物中复合，例如制备医疗装置组分。
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