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    Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
    6.
    发明申请
    Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes 审中-公开
    涉及雷帕霉素抗性和肿瘤发生的哺乳动物基因：rapr7基因

    公开(公告)号：US20060240021A1

    公开(公告)日：2006-10-26

    申请号：US10524426

    申请日：2003-08-18

    申请人： Limin Li ,  Bahman Aghdasi

    发明人： Limin Li ,  Bahman Aghdasi

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12Q1/6886 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136

    摘要： The invention provides nucleotide sequence of a novel mammalian gene which is involved in rapamycin resistance and tumorgenesis the RapR7 gene, and amino acid sequences of its encoded proteins, and fragments and derivatives and analogs thereof. The present invention also provides methods and compositions for regulating rapamycin resistance and/or tumorgenesis by modulating the expression and/or the activity of RapR7 gene. The invention also provides methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression and/or activity of RapR7 gene. The invention also provides methods and compositions for diagnosing and screening RapR7 mediated rapamycin resistance and/or tumorgenesis in patients. The invention further provides host cells whose RapR7 gene can be reversibly overexpressed, and to methods of using the RapR7 gene in evaluation and screening for drugs which regulate rapamycin resistance and/or tumorgenesis.

    摘要翻译： 本发明提供涉及RapR7基因的雷帕霉素抗性和肿瘤发生的新型哺乳动物基因的核苷酸序列，以及其编码的蛋白质的氨基酸序列及其片段和衍生物及其类似物。 本发明还提供了通过调节RapR7基因的表达和/或活性来调节雷帕霉素抗性和/或肿瘤发生的方法和组合物。 本发明还提供了通过调节RapR7基因的表达和/或活性来治疗疾病例如癌症的方法和组合物。 本发明还提供用于诊断和筛选患者中RapR7介导的雷帕霉素抗性和/或肿瘤发生的方法和组合物。 本发明还提供其RapR7基因可以可逆地过表达的宿主细胞，以及使用RapR7基因评估和筛选调节雷帕霉素抗性和/或肿瘤发生的药物的方法。

    Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
    7.
    发明申请
    Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes 审中-公开
    涉及雷帕霉素抗性和肿瘤发生的哺乳动物基因：rapr6基因

    公开(公告)号：US20060099676A1

    公开(公告)日：2006-05-11

    申请号：US10524433

    申请日：2003-08-15

    申请人： Limin Li ,  Bahman Aghdasi

    发明人： Limin Li ,  Bahman Aghdasi

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12Q1/6886 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The invention provides nucleotide sequence of a novel mammalian gene, the RapR6 gene, which is involved in resistance and tumorgenesis, and amino acid sequences of the encoded proteins. The present invention also provides methods and compositions for regulating rapamycin resistance and/or tumorgenesis by modulating the expression and/or the activity of RapR6 gene. The invention also provides methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression and/or activity of RapR6 gene. The invention also provides methods and compositions for diagnosing and screening RapR6 mediated rapamycin resistance and/or tumorgenesis in patients. The invention further provides host cells a portion of whose RapR6 gene can be reversibly expressed, and to methods of using the RapR6 gene in evaluation and screening for drugs which regulate rapamycin resistance and/or tumorgenesis.

    摘要翻译： 本发明提供新的哺乳动物基因的核苷酸序列，涉及抗性和肿瘤发生的RapR6基因以及编码蛋白质的氨基酸序列。 本发明还提供了通过调节RapR6基因的表达和/或活性来调节雷帕霉素抗性和/或肿瘤发生的方法和组合物。 本发明还提供了通过调节RapR6基因的表达和/或活性来治疗疾病例如癌症的方法和组合物。 本发明还提供用于诊断和筛选患者中RapR6介导的雷帕霉素抗性和/或肿瘤发生的方法和组合物。 本发明进一步提供宿主细胞RapR6基因的一部分可以被可逆地表达，以及使用RapR6基因评估和筛选调节雷帕霉素抗性和/或肿瘤发生的药物的方法。

    Methods for detecting enveloped virus infections by measuring cell surface TSG101
    8.
    发明授权
    Methods for detecting enveloped virus infections by measuring cell surface TSG101 失效
    通过测量细胞表面TSG101检测包膜病毒感染的方法

    公开(公告)号：US08476009B2

    公开(公告)日：2013-07-02

    申请号：US12190802

    申请日：2008-08-13

    申请人： Limin Li

    发明人： Limin Li

    IPC分类号： C12Q1/70 ,  C07K16/00

    CPC分类号： C07K16/1045 ,  A61K2039/505 ,  C07K16/1081 ,  C07K16/32 ,  Y02A50/386 ,  Y02A50/466

    摘要： The invention involves the detection of virally infected cells by antibodies or antibody fragments which selectively bind to TSG101. TSG101 is on the surface of mammalian cells, and thus available for detection by antibodies, during viral budding—a phenomenon wherein viral particles escape a virally infected cell after propagation in that cell, so as to infect other cells. To achieve budding, a protein, TSG101 is “hijacked” and misdirected to, or mis-expressed on, the surface of the infected cell. Antibodies can be used to selectively detect such infected cells. Certain TSG101 antibodies may provide therapeutic benefit when administered to infected mammals.

    摘要翻译： 本发明涉及通过选择性结合TSG101的抗体或抗体片段检测病毒感染的细胞。 TSG101位于哺乳动物细胞的表面，因此可用于在病毒出芽期间被抗体检测，这种现象是病毒颗粒在该细胞繁殖后逃离病毒感染的细胞，从而感染其他细胞。 为了实现萌芽，一种蛋白质，TSG101被“劫持”，并被误导或者被感染细胞表面的错误表达。 可以使用抗体来选择性地检测这样的感染细胞。 当被感染的哺乳动物施用时，某些TSG101抗体可以提供治疗益处。

    Mammalian tumor susceptibility genes and their uses
    9.
    发明授权
    Mammalian tumor susceptibility genes and their uses 失效

    公开(公告)号：US08404807B2

    公开(公告)日：2013-03-26

    申请号：US13116911

    申请日：2011-05-26

    申请人： Stanley N. Cohen ,  Limin Li

    发明人： Stanley N. Cohen ,  Limin Li

    IPC分类号： C07K16/00 ,  C07K14/00

    CPC分类号： G01N33/57415 ,  C07K14/4702 ,  C12N15/00 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.