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公开(公告)号:US12005128B1
公开(公告)日:2024-06-11
申请号:US16838907
申请日:2020-04-02
申请人: Lina Cui , Jun Liu , Xiaowei Ma , Ying Wang , Philip Deenik
发明人: Lina Cui , Jun Liu , Xiaowei Ma , Ying Wang , Philip Deenik
IPC分类号: A61K49/00 , G01N33/58 , C07D491/052
CPC分类号: A61K49/0043 , A61K49/0058 , G01N33/582 , C07D491/052 , G01N2458/00
摘要: A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.