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1.发明申请公开(公告)号：US20130030238A1
公开(公告)日：2013-01-31
申请号：US13192426
申请日：2011-07-27
CPC分类号： A61N5/1016 , A61N5/1027 , A61N2005/1022 , A61N2005/1095
摘要： The radial dose function of an electronic x-ray brachytherapy source is flattened by filtering with transition metals in the fourth row of the periodic table, i.e. titanium through nickel. Titanium-walled applicator devices of small diameter, under 10 mm, and with wall thicknesses of about 0.2 mm to 0.6 mm, are disclosed. The walls can be of titanium or alloys thereof, providing adequate strength and flattening the radial dose function curve particularly for x-rays in an energy range of about 45 kV to 55 kV.
摘要翻译： 电子X射线近距离放射治疗源的径向剂量功能通过用周期表第四行中的过渡金属（即钛通过镍）过滤而变平。 公开了直径小于10毫米，壁厚约0.2毫米至0.6毫米的钛壁施用装置。 壁可以是钛或其合金，提供足够的强度并使径向剂量函数曲线变平，特别是对于在约45kV至55kV的能量范围内的X射线。
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公开(公告)号：US08374313B2
公开(公告)日：2013-02-12
申请号：US12802744
申请日：2010-06-11
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1091
摘要： A device, system and method for administering radiation therapy to a tissue surface of a patient utilizes an applicator capable of controlled movement and repositioning over a selected area of tissue, under the control of a computer or controller. A servo-controlled manipulator can effect a raster scan of the desired area, such as an area of the skin, and this can be in any desired pattern such as serpentine, spiral, parallel but unidirectional, or irregular patterns. Preferably a third direction of control is included, i.e. a depth direction, with an appropriate form of depth sensor, a signal from which can be used to adjust the radiation source so that radiation of the tissue surface is consistent over varied contoured.
摘要翻译： 用于向患者的组织表面施用放射治疗的装置，系统和方法利用在计算机或控制器的控制下能够受控地移动和重新定位在组织的选定区域上的施加器。 伺服控制的机械手可以对期望的区域（例如皮肤区域）进行光栅扫描，并且这可以是任何期望的图案，例如蛇形，螺旋，平行但单向或不规则图案。 优选地，包括第三控制方向，即具有适当形式的深度传感器的深度方向，可以使用信号来调整辐射源，使得组织表面的辐射在多种轮廓上是一致的。
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公开(公告)号：US20110305316A1
公开(公告)日：2011-12-15
申请号：US12802744
申请日：2010-06-11
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1091
摘要： A device, system and method for administering radiation therapy to a tissue surface of a patient utilizes an applicator capable of controlled movement and repositioning over a selected area of tissue, under the control of a computer or controller. A servo-controlled manipulator can effect a raster scan of the desired area, such as an area of the skin, and this can be in any desired pattern such as serpentine, spiral, parallel but unidirectional, or irregular patterns. Preferably a third direction of control is included, i.e. a depth direction, with an appropriate form of depth sensor, a signal from which can be used to adjust the radiation source so that radiation of the tissue surface is consistent over varied contoured.
摘要翻译： 用于向患者的组织表面施用放射治疗的装置，系统和方法利用在计算机或控制器的控制下能够受控地移动和重新定位在组织的选定区域上的施加器。 伺服控制的机械手可以对期望的区域（例如皮肤区域）进行光栅扫描，并且这可以是任何期望的图案，例如蛇形，螺旋，平行但单向或不规则图案。 优选地，包括第三控制方向，即具有适当形式的深度传感器的深度方向，可以使用信号来调整辐射源，使得组织表面的辐射在多种轮廓上是一致的。
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4.发明授权MRI method for high liver iron measurement using magnetic susceptibility induced field distortions 失效磁共振成像方法高铁测量使用磁化率诱导磁场畸变
公开(公告)号：US5233992A
公开(公告)日：1993-08-10
申请号：US733309
申请日：1991-07-22
IPC分类号： A61B5/055 , G01R33/24 , G01R33/465 , G01R33/54
CPC分类号： G01R33/4828 , A61B5/055 , A61B5/417 , A61B5/4244 , G01R33/24 , G01R33/465
摘要： A subject (22), such as a human patient, is positioned with a region of interest (24), such as the liver, close proximity to a phantom (12). A Volume image through the liver, the phantom, and adjacent portions of the subject are collected (40) with a magnetic resonance scanner. The phase component of the magnetic resonance data is reconstructed (50) into a three-dimensional phase map. An actually measured field map H.sub.m (r) is determined (42) from the phase map. A geometric model of the volumes occupied by the liver, the phantom, and adjacent portions of the subject are defined mathematically (44). A calculation routine (46) calculates a calculated or estimated field map H.sub.c (r) of the distortions to the magnetic field in the phantom which would be caused by the model. A least squares fit routine (48) (i) compares the calculated field map and the measured field map, (ii) based on the difference adjusts a susceptibility of material in the region of interest as defined in the model, and (iii) recalculates the field map. This fitting procedure is iteratively repeated until a susceptibility is determined for the region of interest which predicts the actually measured field map. This susceptibility is proportional to iron concentration.
摘要翻译： 诸如人类患者的对象（22）被定位成与感兴趣的区域（诸如肝脏）紧邻于体模（12）。 通过磁共振扫描仪收集通过肝脏，体模和受试者的相邻部分的体积图像（40）。 将磁共振数据的相位分量重构（50）成三维相位图。 从相位图确定实际测量的场映射Hm（r）（42）。 数学上定义肝脏，体模以及受试者相邻部分所占据的体积的几何模型（44）。 计算程序（46）计算将由模型引起的对虚线中的磁场的失真的计算或估计的场映射Hc（r）。 最小二乘拟合程序（48）（i）比较计算的场图和测量的场图，（ii）基于该差异来调整模型中定义的感兴趣区域中的材料的易感性，以及（iii）重新计算 场地图。 迭代重复该拟合程序，直到确定感兴趣区域的敏感性，该感兴趣区域预测实际测量的场图。 这种敏感性与铁浓度成正比。
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