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1.发明授权Substituted pyrazoles, compositions containing such compounds and methods of use 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US07625938B2
公开(公告)日：2009-12-01
申请号：US11632198
申请日：2005-07-19
申请人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
发明人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
IPC分类号： A61K31/502 , A61K31/4155 , C07D241/36 , C07D403/04
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和处理方法。 该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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2.发明申请Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use 有权取代吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US20080108620A1
公开(公告)日：2008-05-08
申请号：US11632198
申请日：2005-07-19
申请人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
发明人： Linda Brockunier , Jian Guo , Rui Liang , Emma R. Parmee , Subharekha Raghavan , George Scott Tria , Yusheng Xiong
IPC分类号： A61K31/4155 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K31/498 , A61P3/10 , A61P9/10 , C07D401/04 , C07D403/04 , C07D405/02 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和处理方法。 该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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3.发明授权Pyrazole derivatives, compositions containing such compounds and methods of use 有权吡唑衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US07799818B2
公开(公告)日：2010-09-21
申请号：US12405600
申请日：2009-03-17
申请人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
发明人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
IPC分类号： A61K31/415 , A61K31/4162 , C07D231/10
CPC分类号： C07D231/12 , C07D405/04
摘要： Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了具有连接的萘基的吡唑。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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4.发明授权Pyrazole derivatives, compositions containing such compounds and methods of use 有权吡唑衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US07598285B2
公开(公告)日：2009-10-06
申请号：US11144332
申请日：2005-06-03
申请人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
发明人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
IPC分类号： A61K31/416 , C07D231/02
CPC分类号： C07D231/12 , C07D405/04
摘要： Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了具有连接的萘基的吡唑。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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5.发明申请PYRAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 有权吡唑衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US20090176854A1
公开(公告)日：2009-07-09
申请号：US12405600
申请日：2009-03-17
申请人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
发明人： Emma R. Parmee , Yusheng Xiong , Jian Guo , Rui Liang , Linda Brockunier
IPC分类号： A61K31/415 , A61P3/06
CPC分类号： C07D231/12 , C07D405/04
摘要： Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了具有连接的萘基的吡唑。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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6.发明授权Pyrazole amide derivatives, compositions containing such compounds and methods of use 失效吡唑酰胺衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US07649009B2
公开(公告)日：2010-01-19
申请号：US11631580
申请日：2005-07-01
IPC分类号： A61K31/4155 , C07D231/10 , C07D401/06
CPC分类号： C07D403/12 , C07D231/14 , C07D233/90 , C07D401/06 , C07D401/14 , C07D417/12
摘要： Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 披露吡唑酰胺。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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公开(公告)号：US08741910B2
公开(公告)日：2014-06-03
申请号：US13127334
申请日：2009-11-16
申请人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
发明人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , A61P9/12 , A61P9/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.
摘要翻译： 式I的化合物能够调节人体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与扰乱的cGMP平衡相关的疾病。 本发明还涉及制备式I化合物的方法，其用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式I化合物的药物制剂。
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公开(公告)号：US20130072492A1
公开(公告)日：2013-03-21
申请号：US13699046
申请日：2011-05-24
申请人： Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
发明人： Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
IPC分类号： C07D487/04 , C07D495/04 , A61K31/5025 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04 , A61P7/02 , A61P15/00 , A61P11/06 , A61P13/12 , A61P3/10 , A61P1/16 , A61P9/08 , A61P3/00 , A61P3/06 , A61P7/10 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物或其药学上可接受的盐能够调节人体的环鸟苷酸（cGMP）的产生，并且通常适用于治疗和预防与扰动的cGMP平衡有关的疾病。 本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。
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公开(公告)号：US20110218202A1
公开(公告)日：2011-09-08
申请号：US13127334
申请日：2009-11-16
申请人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
发明人： Linda L. Brockunier , Jian Guo , Emma R. Parmee , Subharekha Raghavan , Keith Rosauer , Darby Schmidt , John E. Stelmach
IPC分类号： A61K31/519 , C07D487/04 , C07D495/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04 , A61P7/02 , A61P13/12 , A61P1/16 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.
摘要翻译： 式I的化合物能够调节人体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与扰乱的cGMP平衡相关的疾病。 本发明还涉及制备式I化合物的方法，其用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式I化合物的药物制剂。
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公开(公告)号：US09365574B2
公开(公告)日：2016-06-14
申请号：US13699046
申请日：2011-05-24
申请人： Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
发明人： Subharekha Raghavan , John E. Stelmach , Cameron J. Smith , Hong Li , Alan Whitehead , Sherman T. Waddell , Yi-Heng Chen , Shouwu Miao , Olga A. Ornoski , Joie Garfunkle , Xibin Liao , Jiang Chang , Xiaoqing Han , Jian Guo , Jonathan A. Groeper , Linda L. Brockunier , Keith Rosauer , Emma R. Parmee
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P29/00 , A61P9/12 , A61P3/10 , A61P9/10 , A61P11/06 , A61P15/10 , A61P9/04 , A61P13/12 , A61P1/16
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物或其药学上可接受的盐能够调节身体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与受干扰的cGMP平衡相关的疾病 。 本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。
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