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25 条记录 (耗时 0.024 秒)

    Method of treating hair loss using sulfonyl thyromimetic compounds
    1.
    发明授权
    Method of treating hair loss using sulfonyl thyromimetic compounds 失效
    使用磺酰甲状腺素化合物治疗脱发的方法

    公开(公告)号：US06646005B1

    公开(公告)日：2003-11-11

    申请号：US09980351

    申请日：2002-02-21

    申请人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    发明人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    IPC分类号： A61K3150

    CPC分类号： A61Q7/00 ,  A61K8/46 ,  A61K8/4953

    摘要： Methods for treating hair loss using a composition including a compound having the following structure and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof are provided. R1 is —(CH2)n(CHNR7R8)mC(O)R9, wherein n is an integer from 1 to 3, and m is an integer from 0 to 1. R3 and R5each, independently, is chlorine, bromine, iodine and —CH3. R7 and R8 each, independently, is hydrogen or C1 to C4 alkyl. R9 is hydroxy, C1 to C4 alkoxy and —NR7R8. R31 is a hydrogen, chlorine, bromine, iodine, C1 to C4 alkyl, C4 to C6 cycloalklyl, C1 to C4 haloalkyl, C4 to C6 halocycloalkyl, or CH(R10)Ar. Ar is 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methioxypyridazin-3-yl N-oxide or 6-hydroxypyridazin-3-yl N-oxide. R10 is hydrogen or C1 to C4 alkyl. R41 is hydroxy or C1 to C4 alkoxy.

    摘要翻译： 提供了使用包含具有以下结构的化合物和药学上可接受的盐，水合物和生物可水解的酰胺，酯和酰亚胺的组合物来治疗脱发的方法。 R 1为 - （CH 2）n（CHNR 7 R 8）m C（O）R 9，其中n为1至3的整数，m为0至1的整数。R 3和R 5各自独立地为氯，溴，碘和 - CH3。 R 7和R 8各自独立地是氢或C 1至C 4烷基。 R9是羟基，C1-C4烷氧基和-NR7R8。 R31是氢，氯，溴，碘，C1至C4烷基，C4至C6环烷基，C1至C4卤代烷基，C4至C6卤代环烷基或CH（R10）Ar。 Ar是5-羟基吡啶-2-基，6-羟基吡啶-3-基，6-羟基哒嗪-3-基，6-甲氧基哒嗪-3-基N-氧化物或6-羟基哒嗪-3-基N-氧化物。 R 10是氢或C 1至C 4烷基。 R41是羟基或C1-C4烷氧基。

    Method of treating hair loss using diphenylether derivatives
    2.
    发明授权
    Method of treating hair loss using diphenylether derivatives 失效
    使用二苯醚衍生物治疗脱发的方法

    公开(公告)号：US06525094B1

    公开(公告)日：2003-02-25

    申请号：US09980408

    申请日：2000-12-08

    申请人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    发明人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    IPC分类号： A61K3124

    CPC分类号： A61K8/44 ,  A61Q7/00

    摘要： The present invention describes methods for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The methods comprise administering a cardiac-sparing compound which is a derivative of diphenylether and pharmaceutically-acceptable carrier.

    摘要翻译： 本发明描述了治疗哺乳动物脱发的方法，包括阻止和/或逆转脱发并促进毛发生长。 所述方法包括施用作为二苯醚衍生物的心脏保留化合物和药学上可接受的载体。

    Method of treating hair loss using diphenylmethane derivatives
    3.
    发明授权
    Method of treating hair loss using diphenylmethane derivatives 失效
    使用二苯基甲烷衍生物治疗脱发的方法

    公开(公告)号：US06680344B1

    公开(公告)日：2004-01-20

    申请号：US09980407

    申请日：2002-03-29

    申请人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    发明人： Lixin Lilly Zhang ,  Robert Scott Youngquist

    IPC分类号： A61K31192

    CPC分类号： A61K31/192 ,  A61K8/365 ,  A61Q7/00

    摘要： The present invention relates to a method of treating hair loss comprising administering a composition having a cardiac-sparing compound characterized by the structure: and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof. In this compound, n may be an integer from 1 to 3; R1 and R2 may each, independently, be a hydrogen or lower alkyl; R4 may be hydrogen, lower alkyl or cycloalkyl; R6 and R9 may each, independently, be hydrogen or lower alkyl; R7 and R8 may each, independently, be hydrogen, lower alkyl, substituted phenyl, or substituted benzyl; R10 may be hydrogen, lower alkyl, cycloalkyl, or acyl; and R11 may be hydrogen, lower alkyl, or cycloalkyl.

    摘要翻译： 本发明涉及治疗脱发的方法，其包括给予具有以下结构为特征的心脏保留化合物的组合物：及其药学上可接受的盐，水合物和可生物水解的酰胺，酯和酰亚胺。 在该化合物中，n可以是1至3的整数; R 1和R 2可各自独立地为氢或低级烷基; R4可以是氢，低级烷基或环烷基; R6和R9各自独立地为氢或低级烷基; R 7和R 8各自独立地为氢，低级烷基，取代的苯基或取代的苄基; R 10可以是氢，低级烷基，环烷基或酰基; R 11可以是氢，低级烷基或环烷基。