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    Medical devices coated with drug carrier macromolecules
    1.
    发明申请
    Medical devices coated with drug carrier macromolecules 有权
    用药物载体大分子涂覆的医疗器械

    公开(公告)号：US20070269479A1

    公开(公告)日：2007-11-22

    申请号：US11435690

    申请日：2006-05-18

    申请人： Liza Davis ,  Kim Robertson ,  Richard Tooley

    发明人： Liza Davis ,  Kim Robertson ,  Richard Tooley

    IPC分类号： A61K39/395 ,  A61F2/02

    CPC分类号： A61L31/16 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L2300/602

    摘要： A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.

    摘要翻译： 涂覆有载体大分子的医疗装置，其中载体大分子与治疗剂缀合。 载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。 载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。 载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。 载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。 在一些情况下，靶抗原的结合导致治疗剂从双特异性抗体释放。 还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。

    Bifurcated stent with multiple locations for side branch access
    2.
    发明申请
    Bifurcated stent with multiple locations for side branch access 审中-公开
    具有多个位置用于侧支通路的分叉支架

    公开(公告)号：US20070142904A1

    公开(公告)日：2007-06-21

    申请号：US11314115

    申请日：2005-12-20

    申请人： Shawn Sorenson ,  Richard Tooley ,  Michael Meyer ,  Daniel Gregorich

    发明人： Shawn Sorenson ,  Richard Tooley ,  Michael Meyer ,  Daniel Gregorich

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533

    摘要： A stent has an undeployed state and a deployed state. The stent has a primary body with an outer surface and an inner surface with a wall extending therebetween. The inner surface defines a first lumen having a first longitudinal axis therethrough. The primary body has at least two side branch portions which define secondary lumens having a second longitudinal axis therethrough. The first lumen and the secondary lumen are in fluid communication and in the deployed state one of the side branch portions deploy and the second longitudinal axis forms an oblique angle with the first longitudinal axis.

    摘要翻译： 支架具有未部署状态和展开状态。 支架具有主体，其具有外表面和内表面，其间延伸有壁。 内表面限定了具有穿过其中的第一纵向轴线的第一内腔。 主体具有限定具有穿过其中的第二纵向轴线的次级腔的至少两个侧分支部分。 第一管腔和第二内腔处于流体连通并且在展开状态中，一个侧分支部分展开，第二纵向轴线与第一纵向轴线形成倾斜角。

    Tapered strength rings on a bifurcated stent petal
    5.
    发明申请
    Tapered strength rings on a bifurcated stent petal 审中-公开
    锥形强度环在分叉支架花瓣上

    公开(公告)号：US20070208414A1

    公开(公告)日：2007-09-06

    申请号：US11368846

    申请日：2006-03-06

    申请人： Shawn Sorenson ,  Richard Tooley ,  Michael Meyer ,  Daniel Gregorich

    发明人： Shawn Sorenson ,  Richard Tooley ,  Michael Meyer ,  Daniel Gregorich

    IPC分类号： A61F2/94

    CPC分类号： A61F2/82 ,  A61F2/856 ,  A61F2/91 ,  A61F2002/065

    摘要： A stent assembly comprises a second stent body and a substantially tubular first stent body defining a first lumen and containing a side branch opening. In an undeployed state, the second stent body is at least partially comprised of rings having peaks and spans between these peaks. In a deployed state, the rings of the second stent body define a second lumen opening in fluid communication with the first lumen. The second lumen is capable of having tapering strength and geometry and can extend and form an oblique angle relative to the longitudinal axis of the first stent body.

    摘要翻译： 支架组件包括第二支架主体和限定第一内腔并且包含侧分支开口的基本管状的第一支架主体。 在非部署状态下，第二支架主体至少部分地由在这些峰之间具有峰值和跨度的环构成。 在展开状态下，第二支架主体的环限定与第一管腔流体连通的第二管腔开口。 第二腔能够具有渐缩强度和几何形状，并且可以相对于第一支架主体的纵向轴线延伸并形成倾斜角。

    Connectors for bifurcated stent
    6.
    发明申请
    Connectors for bifurcated stent 有权
    分支支架连接器

    公开(公告)号：US20070135903A1

    公开(公告)日：2007-06-14

    申请号：US11300033

    申请日：2005-12-14

    申请人： Daniel Gregorich ,  Michael Meyer ,  Richard Tooley ,  Shawn Sorenson

    发明人： Daniel Gregorich ,  Michael Meyer ,  Richard Tooley ,  Shawn Sorenson

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2250/006

    摘要： A stent assembly comprises a second stent body and a substantially tubular first stent body defining a first lumen and containing a side branch opening. In an undeployed state, the second stent body is at least partially comprised of rings having peaks and valleys at least some of the valleys of adjacent rings being interconnected by bridges. In an expanded state, the rings of the second stent body define a second lumen opening in fluid communication with the first lumen. The second lumen has superior body vessel coverage and is flexible enough to form an oblique angle relative to the longitudinal axis of the first stent body.

    摘要翻译： 支架组件包括第二支架主体和限定第一内腔并且包含侧分支开口的基本管状的第一支架主体。 在非部署状态下，第二支架主体至少部分地由具有峰和谷的环组成，相邻环的至少一些谷通过桥互连。 在扩张状态下，第二支架主体的环限定与第一管腔流体连通的第二管腔开口。 第二内腔具有优异的体血管覆盖度并且足够灵活以相对于第一支架主体的纵向轴线形成倾斜角。

    Bifurcation stent pattern
    7.
    发明申请
    Bifurcation stent pattern 有权
    分叉支架模式

    公开(公告)号：US20070150046A1

    公开(公告)日：2007-06-28

    申请号：US11315084

    申请日：2005-12-22

    申请人： Michael Meyer ,  Daniel Gregorich ,  Shawn Sorenson ,  Richard Tooley

    发明人： Michael Meyer ,  Daniel Gregorich ,  Shawn Sorenson ,  Richard Tooley

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575

    摘要： A stent may comprise a plurality of serpentine bands connected by connector struts. The stent may further comprise a side branch cell having a plurality of outwardly deployable petals. Each serpentine band may have an approximate longitudinal axis. A portion of the serpentine bands may be flared in the unexpanded state, wherein a portion of the axis of each flared band is oriented helically about a portion of the stent. The bands may reorient during stent expansion, whereafter the axis of each band is oriented in a circumferential direction.

    摘要翻译： 支架可以包括通过连接器支柱连接的多个蛇形带。 支架还可以包括具有多个可向外展开的瓣的侧分支细胞。 每个蛇形带可以具有近似的纵轴。 蛇纹带的一部分可以在未展开状态下扩张，其中每个扩张带的轴线的一部分围绕支架的一部分螺旋形取向。 带可能在支架扩张期间重新定向，之后每个带的轴线在圆周方向上定向。