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1.发明授权Compounds and methods for treating mammalian gastrointestinal microbial infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US08969342B2
公开(公告)日：2015-03-03
申请号：US13257418
申请日：2010-03-22
申请人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Boris Striepen , Suresh Kumar Gorla , Mandapati Kavitha
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Boris Striepen , Suresh Kumar Gorla , Mandapati Kavitha
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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2.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US20120101096A1
公开(公告)日：2012-04-26
申请号：US13257418
申请日：2010-03-22
申请人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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3.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections 审中-公开用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法公开(公告)号：US20100022547A1
公开(公告)日：2010-01-28
申请号：US12302600
申请日：2007-06-01
IPC分类号： A61K31/498 , A61K31/165 , C07C233/01 , A61K31/426 , C07D277/20 , A61K31/502 , C07D237/30 , A61K31/47 , C07D215/00 , A61K31/519 , C07D495/02 , A61K31/4184 , C07D235/02 , C07D241/36 , A61K31/4433 , C07D405/02 , A61P33/02
CPC分类号： A61K31/4439 , Y02A50/409 , Y02A50/411 , Y02A50/488
摘要： One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本发明的一个方面涉及可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 本发明还提供包含选择性抑制寄生性IMPDH的本发明化合物的药物组合物。 在某些实施方案中，本发明涉及副肌苷-5'-单磷酸脱氢酶对人肌苷-5'-单磷酸脱氢酶（IMPDH I型和II型）的选择性抑制。 这些化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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4.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections 审中-公开用于治疗哺乳动物胃肠道寄生虫感染的化合物和方法公开(公告)号：US20120264760A1
公开(公告)日：2012-10-18
申请号：US13490002
申请日：2012-06-06
IPC分类号： A61K31/167 , C07C233/29 , C07D417/04 , A61K31/427 , C07D237/32 , A61K31/502 , C07D215/50 , A61K31/4704 , C07D495/04 , A61K31/519 , C07D235/02 , A61K31/4184 , C07D241/52 , A61K31/498 , C07D405/12 , A61K31/4433 , C07C237/20 , C07D213/75 , A61P33/02 , A61P33/04 , A61K31/4409 , C07C217/84 , A61K31/137 , C07C233/75 , C07C235/24
CPC分类号： A61K31/4439 , Y02A50/409 , Y02A50/411 , Y02A50/488
摘要： One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本发明的一个方面涉及可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 本发明还提供包含选择性抑制寄生性IMPDH的本发明化合物的药物组合物。 在某些实施方案中，本发明涉及副肌苷-5'-单磷酸脱氢酶对人肌苷-5'-单磷酸脱氢酶（IMPDH I型和II型）的选择性抑制。 这些化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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