公开(公告)号：US20130154583A1

公开(公告)日：2013-06-20

申请号：US13700426

申请日：2011-10-17

申请人： Longxing Shi ,  Weiwei Shan ,  Jun Yang ,  Haolin Gu ,  Xinning Liu ,  Yang Zhang

发明人： Longxing Shi ,  Weiwei Shan ,  Jun Yang ,  Haolin Gu ,  Xinning Liu ,  Yang Zhang

IPC分类号： G05F1/10

CPC分类号： G05F1/10 ,  G06F1/26 ,  G06F11/008 ,  G06F11/3058

摘要： The present invention discloses a dynamic voltage scaling system based on on-chip monitoring and voltage prediction, comprising a main circuit that has integrated on-chip monitoring circuits, a supply voltage scaling module, and voltage converters, wherein, the supply voltage scaling module comprises a sampling and statistics module designed to calculate the error rate of the main circuit in the current time slice, a state recording module designed to record the error rate and the corresponding supply voltage, an error prediction module, and a state transition probability generation module; the error prediction module predicts the error trend of the main circuit in a future time slice according to the state recording module and the state transition probability generation module, and generates regulation signals and sends to the corresponding voltage converters, so as to generate the voltage required for operation of the entire main circuit. The present invention utilizes the Markov theory to predict the “future” timing violation level of the circuit according to the “past” working condition and “current” working condition of the main circuit, and reserves some time for voltage scaling in the voltage converters; as a result, the dynamic voltage scaling has high directivity and purposiveness.

摘要翻译： 本发明公开了一种基于片上监控和电压预测的动态电压缩放系统，包括具有集成片上监控电路的主电路，电源电压缩放模块和电压转换器，其中电源电压缩放模块包括 用于计算当前时间片中主电路的误码率的采样和统计模块，设计用于记录错误率和相应电源电压的状态记录模块，误差预测模块和状态转移概率生成模块; 误差预测模块根据状态记录模块和状态转移概率生成模块预测未来时间片中主电路的误差趋势，并产生调节信号并发送到相应的电压转换器，以产生所需的电压 用于整个主电路的操作。 本发明利用马尔可夫理论根据主电路的“过去”工作条件和“当前”工作状态预测电路的“未来”时序违规等级，并为电压转换器中的电压调整预留一些时间; 因此，动态电压调整具有很高的方向性和目的性。

公开(公告)号：US08909999B2

公开(公告)日：2014-12-09

申请号：US13700426

申请日：2011-10-17

申请人： Longxing Shi ,  Weiwei Shan ,  Jun Yang ,  Haolin Gu ,  Xinning Liu ,  Yang Zhang

发明人： Longxing Shi ,  Weiwei Shan ,  Jun Yang ,  Haolin Gu ,  Xinning Liu ,  Yang Zhang

IPC分类号： G06F11/00 ,  G05F1/10 ,  G06F1/26 ,  G06F11/30

CPC分类号： G05F1/10 ,  G06F1/26 ,  G06F11/008 ,  G06F11/3058

摘要： A dynamic voltage scaling system based on on-chip monitoring and voltage prediction is disclosed, comprising a main circuit that has integrated on-chip monitoring circuits, a supply voltage scaling module, and voltage converters, wherein, the supply voltage scaling module comprises a sampling and statistics module designed to calculate the error rate of the main circuit in the current time slice, a state recording module designed to record the error rate and the corresponding supply voltage, an error prediction module, and a state transition probability generation module; the error prediction module predicts the error trend of the main circuit in a future time slice according to the state recording module and the state transition probability generation module, and generates regulation signals and sends to the corresponding voltage converters, so as to generate the voltage required for operation of the entire main circuit.

摘要翻译： 公开了一种基于片上监控和电压预测的动态电压缩放系统，其包括具有集成片上监控电路的主电路，电源电压缩放模块和电压转换器，其中，电源电压缩放模块包括采样 统计模块设计用于计算当前时间片中主电路的误码率，设计为记录错误率和相应电源电压的状态记录模块，误差预测模块和状态转移概率生成模块; 误差预测模块根据状态记录模块和状态转移概率生成模块预测未来时间片中主电路的误差趋势，并产生调节信号并发送到相应的电压转换器，以产生所需的电压 用于整个主电路的操作。

公开(公告)号：US08703975B2

公开(公告)日：2014-04-22

申请号：US13320101

申请日：2009-12-24

申请人： Luhong Tang ,  Ajuan Dai ,  Ze Wang ,  Yang Sun ,  Xinning Liu ,  Lingyan Xu ,  Xin Fang ,  Shuang Qiu ,  Yaqing Cao ,  Xiaomin Xu ,  Ruixia Jiang ,  Chao Wu

发明人： Luhong Tang ,  Ajuan Dai ,  Ze Wang ,  Yang Sun ,  Xinning Liu ,  Lingyan Xu ,  Xin Fang ,  Shuang Qiu ,  Yaqing Cao ,  Xiaomin Xu ,  Ruixia Jiang ,  Chao Wu

IPC分类号： C07D307/62

CPC分类号： C07D307/62 ,  C07D405/12 ,  C07D491/04 ,  C07D491/052 ,  C12P17/04 ,  C12P17/16 ,  C12P17/188 ,  C12Y301/01003

摘要： The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children. The aryl (ethanoic) propanoic acid ascorbyl ester can be converted into ascorbyl ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water solubility thereof, facilitate intravenously administration, reduce the onset time, improve the bioavailability, reduce the stimulation effect to gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of arthritis, dysmenorrheal, multiple sclerosis, pneumonia cystic fibrosis and patent ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-ischemic brain damage, senile dementia and certain cancers.

摘要翻译： 本发明设计和合成芳基（乙酸）丙酸非甾体抗炎药物如布洛芬，酮洛芬和萘普生的抗坏血酸酯衍生物，以及衍生物与药物酸或药物碱的加成盐。 以布洛芬为代表的非甾体抗炎药是常见的解热止痛药。 本发明除抗炎作用外，具有明显的解热镇痛作用，安全性好，不仅适用于成人，而且适用于老年人，婴儿和儿童。 芳基（乙酸）丙酸抗坏血酸酯可以转化为抗坏血酸酯衍生物，并且衍生物的加成盐与药物酸或药物碱性可以改善其水溶性，有助于静脉内施用，减少发病时间，提高生物利用度 降低对胃肠道的刺激作用，增强血液渗透屏障的穿透能力，可用作新型药物，用于消炎止痛，止痛，止痛，治疗关节炎，痛经，多发性硬化，肺炎囊性纤维化，以及 早产儿动脉导管未闭，预防和治疗脑中风，缺氧缺血性脑损伤，老年性痴呆和某些癌症。

公开(公告)号：US20120115897A1

公开(公告)日：2012-05-10

申请号：US13320101

申请日：2009-12-24

申请人： Luhong Tang ,  Ajuan Dai ,  Ze Wang ,  Yang Sun ,  Xinning Liu ,  Lingyan Xu ,  Xin Fang ,  Shuang Qiu ,  Yaqing Cao ,  Xiaomin Xu ,  Ruixia Jiang ,  Chao Wu

发明人： Luhong Tang ,  Ajuan Dai ,  Ze Wang ,  Yang Sun ,  Xinning Liu ,  Lingyan Xu ,  Xin Fang ,  Shuang Qiu ,  Yaqing Cao ,  Xiaomin Xu ,  Ruixia Jiang ,  Chao Wu

IPC分类号： A61K31/436 ,  C07D491/052 ,  C12P17/04 ,  C12P17/18 ,  A61K31/375 ,  A61K31/407 ,  A61P29/00 ,  A61P19/02 ,  A61P25/00 ,  A61P25/28 ,  A61P35/00 ,  A61P15/00 ,  A61P11/00 ,  A61P9/00 ,  C07D307/62

CPC分类号： C07D307/62 ,  C07D405/12 ,  C07D491/04 ,  C07D491/052 ,  C12P17/04 ,  C12P17/16 ,  C12P17/188 ,  C12Y301/01003

摘要： The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children. The aryl (ethanoic) propanoic acid ascorbyl ester can be converted into ascorbyl ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water solubility thereof, facilitate intravenously administration, reduce the onset time, improve the bioavailability, reduce the stimulation effect to gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of arthritis, dysmenorrheal, multiple sclerosis, pneumonia cystic fibrosis and patent ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-ischemic brain damage, senile dementia and certain cancers.

摘要翻译： 本发明设计和合成芳基（乙酸）丙酸非甾体抗炎药物如布洛芬，酮洛芬和萘普生的抗坏血酸酯衍生物，以及衍生物与药物酸或药物碱的加成盐。 以布洛芬为代表的非甾体抗炎药是常见的解热止痛药。 本发明除抗炎作用外，具有明显的解热镇痛作用，安全性好，不仅适用于成人，而且适用于老年人，婴儿和儿童。 芳基（乙酸）丙酸抗坏血酸酯可以转化为抗坏血酸酯衍生物，并且衍生物的加成盐与药物酸或药物碱性可以改善其水溶性，有助于静脉内施用，减少发病时间，提高生物利用度 降低对胃肠道的刺激作用，增强血液渗透屏障的穿透能力，可用作新型药物，用于消炎止痛，止痛，止痛，治疗关节炎，痛经，多发性硬化，肺炎囊性纤维化，以及 早产儿动脉导管未闭，预防和治疗脑中风，缺氧缺血性脑损伤，老年性痴呆和某些癌症。