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公开(公告)号：US08361510B2
公开(公告)日：2013-01-29
申请号：US12997983
申请日：2009-06-16
CPC分类号： A61K31/70 , A61K9/5138
摘要： The various embodiments of the present disclosure relate generally to nanogels for the cellular delivery of therapeutics and methods of using the same. More particularly, the various embodiments of the present invention are directed to systems and methods for the targeted treatment of neoplastic using nanogel-based technologies. In an embodiment of the present invention, a nanogel-based delivery system comprises: a nanogel comprising a crosslinked polymer particle; and an active agent contained substantially within the nanogel, wherein the active agent is non-covalently associated with the nanogel.
摘要翻译： 本公开的各种实施方案通常涉及用于细胞递送治疗剂的纳米凝胶及其使用方法。 更具体地，本发明的各种实施方案涉及使用基于纳米凝胶的技术靶向治疗肿瘤的系统和方法。 在本发明的一个实施方案中，基于纳米凝胶的递送系统包括：包含交联聚合物颗粒的纳米凝胶; 和基本上含有纳米凝胶的活性剂，其中活性剂与纳米凝胶非共价结合。
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公开(公告)号：US20110091562A1
公开(公告)日：2011-04-21
申请号：US12997983
申请日：2009-06-16
CPC分类号： A61K31/70 , A61K9/5138
摘要： The various embodiments of the present disclosure relate generally to nanogels for the cellular delivery of therapeutics and methods of using the same. More particularly, the various embodiments of the present invention are directed to systems and methods for the targeted treatment of neoplastic using nanogel-based technologies. In an embodiment of the present invention, a nanogel-based delivery system comprises: a nanogel comprising a crosslinked polymer particle; and an active agent contained substantially within the nanogel, wherein the active agent is non-covalently associated with the nanogel.
摘要翻译： 本公开的各种实施方案通常涉及用于细胞递送治疗剂的纳米凝胶及其使用方法。 更具体地，本发明的各种实施方案涉及使用基于纳米凝胶的技术靶向治疗肿瘤的系统和方法。 在本发明的一个实施方案中，基于纳米凝胶的递送系统包括：包含交联聚合物颗粒的纳米凝胶; 和基本上含有纳米凝胶的活性剂，其中活性剂与纳米凝胶非共价结合。
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3.发明授权公开(公告)号：US07223596B2
公开(公告)日：2007-05-29
申请号：US10655727
申请日：2003-09-05
CPC分类号： C12N5/0693 , C12N5/069 , C12N2503/02 , C12N2510/04
摘要： An immortalized hemangiosarcoma cell line of malignant canine endothelial cells which possesses surface expression characteristics and growth factor and cytokine expression profiles typical of nonmalignant activated endothelial cells is provided. In vitro and in vivo models for angiogenesis produced from this cell line as well as methods for identifying antiangiogenic agents using these models are also provided.
摘要翻译： 提供了具有非恶性活化内皮细胞的表达表达特征和生长因子和细胞因子表达谱的恶性犬内皮细胞的永生化血管肉瘤细胞系。 还提供了从该细胞系产生的用于血管生成的体外和体内模型以及使用这些模型鉴定抗血管生成剂的方法。
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4.发明申请DEVICE AND METHOD OF USING SUPERPARAMAGNETIC NANOPARTICLES IN TREATMENT AND REMOVAL OF CELLS 审中-公开超临界纳米颗粒在细胞处理和移除中的使用方法和方法公开(公告)号：US20110098623A1
公开(公告)日：2011-04-28
申请号：US12999077
申请日：2009-06-17
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26
摘要： Methods and devices for selectively removing from a subject a target cell, pathogen, or virus expressing a binding partner on its surface are presented. In one embodiment, the device contains an excorporeal circuit, which includes, at least, a magnetic filter comprising a magnet and a removable, magnetizable substrate capable of capturing magnetic nanomaterials; and a pump in fluid communication with the magnetic filter, wherein the pump moves fluid through the excorporeal circuit. The magnet is capable of generating a magnetic field sufficient to capture magnetic nanomaterials in the magnetic field. In a preferred embodiment, the target cells are cancer cells and/or cells infected with pathogenic agents. The devices may be designed for extracorporeal or in vivo uses. Functionalized superparamagnetic nanoparticles are either mixed ex vivo with a biological fluid from the patient or injected into the patient. Then the biological fluid, which includes the nanoparticles is transported to the magnetic filter to remove any nanoparticles that are complexed to the target cells, pathogens, or virus, and any free nanoparticles. Optionally, the functionalized nanoparticles contain and deliver a therapeutic agent. In one embodiment, the therapeutic agent is released when the nanoparticle binds to the target cells, pathogens, or virus.
摘要翻译： 提出了用于选择性地从受试者中除去表面结合配偶体的靶细胞，病原体或病毒的方法和装置。 在一个实施例中，该装置包含一个体外电路，其至少包括一个磁性过滤器，该磁性过滤器包括一个能够捕获磁性纳米材料的磁体和一个可拆卸的可磁化衬底; 以及与所述磁性过滤器流体连通的泵，其中所述泵将流体移动通过所述体外回路。 磁体能够产生足以在磁场中捕获磁性纳米材料的磁场。 在一个优选实施方案中，靶细胞是感染病原体的癌细胞和/或细胞。 这些装置可以设计用于体外或体内使用。 将功能化超顺磁性纳米颗粒与来自患者的生物流体离体混合或注射到患者体内。 然后将包括纳米颗粒的生物流体输送到磁性过滤器以除去与靶细胞，病原体或病毒以及任何游离纳米颗粒复合的任何纳米颗粒。 任选地，官能化纳米颗粒含有并递送治疗剂。 在一个实施方案中，当纳米颗粒结合靶细胞，病原体或病毒时，治疗剂被释放。
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