公开(公告)号：US20050059999A1

公开(公告)日：2005-03-17

申请号：US10663570

申请日：2003-09-15

申请人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

发明人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

IPC分类号： A61K48/00 ,  A61N1/05 ,  A61N1/362

CPC分类号： A61N1/0568 ,  A61K48/0008 ,  A61K48/0041 ,  A61K48/0083

摘要： Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

摘要翻译： 将遗传物质递送至刺激部位会在刺激部位引起组织的转基因表达。 在一些实施方案中，递送的遗传物质导致蛋白质（例如连接蛋白，间隙连接和离子通道）的表达增加，以增加刺激部位组织的电导率。 在一些实施方案中，递送的遗传物质导致金属蛋白酶，抗炎剂或免疫抑制剂的表达。 遗传物质通过刺激引线输送到刺激部位。 用于将遗传物质递送至刺激部位的刺激引线包括含有聚合物基质的腔室。 基质吸收遗传物质并将遗传物质洗脱到刺激部位。

公开(公告)号：US20070167843A1

公开(公告)日：2007-07-19

申请号：US11565092

申请日：2006-11-30

申请人： Yong Cho ,  Steven Lu ,  Luc Mongeon ,  Scott Davie ,  Todd Sheldon ,  Mark Erickson ,  H. Markowitz

发明人： Yong Cho ,  Steven Lu ,  Luc Mongeon ,  Scott Davie ,  Todd Sheldon ,  Mark Erickson ,  H. Markowitz

IPC分类号： A61B5/02 ,  A61B5/08

CPC分类号： A61B5/0809 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/1459 ,  A61B5/4818 ,  G06F19/00

摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

摘要翻译： 一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。 该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。 可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。 呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。 心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

公开(公告)号：US20060271117A1

公开(公告)日：2006-11-30

申请号：US11135921

申请日：2005-05-24

申请人： John Burnes ,  David Igel ,  John Rueter ,  Yong Cho ,  Luc Mongeon ,  Harold Stone ,  Jodi Zilinski

发明人： John Burnes ,  David Igel ,  John Rueter ,  Yong Cho ,  Luc Mongeon ,  Harold Stone ,  Jodi Zilinski

IPC分类号： A61N1/362

CPC分类号： A61N1/36521

摘要： Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.

摘要翻译： 阻抗，例如 亚阈值阻抗是在选定心脏周期时间内心脏测量的，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。 其他方法改变AA间隔以最大化整个心动周期或心房周期期间的阻抗变化。

公开(公告)号：US20060149339A1

公开(公告)日：2006-07-06

申请号：US11368563

申请日：2006-03-06

申请人： John Burnes ,  Luc Mongeon

发明人： John Burnes ,  Luc Mongeon

IPC分类号： A61N1/08

CPC分类号： A61B5/0031 ,  G06F19/00

摘要： An implantable device is described that collects and aggregates data from non-implanted medical devices external from a body of a patient. The device may also collect and aggregate data from medical devices implanted within the body. The implantable device includes a wireless transceiver to acquire physiological data from the external medical devices, and a storage medium to store the physiological data. A processor retrieves the physiological data and communicates the physiological data to a remote patient management system. The device may collect the physiologic data from the various external data sources, possibly over an extended period of time, and stores the data for subsequent upload to a common patient management system. In addition, the implantable device may collect physiological data from other medical devices implanted within the patient. In this manner, the device provides a central point for collection and aggregation of physiological data relating to the patient.

公开(公告)号：US20060020491A1

公开(公告)日：2006-01-26

申请号：US10946473

申请日：2004-09-21

申请人： Luc Mongeon ,  Marta Jackson ,  Daniel Boulay

发明人： Luc Mongeon ,  Marta Jackson ,  Daniel Boulay

IPC分类号： G06Q50/00

CPC分类号： G06F19/3418 ,  A61B5/0031 ,  G06F19/3481 ,  G06Q10/1095 ,  G06Q50/22 ,  G16H40/20

摘要： A method for managing data from remotely located patients features batch processing. Patient files are batched in groups to increase workflow efficiency of a caregiver clinic. Scheduling of remote data transmission; accessing, reviewing and evaluating the data; and billing are carried out using a batch processing approach.

摘要翻译： 从远程位置的病人管理数据的方法是批处理。 患者文件分组批量，以提高照顾者诊所的工作效率。 远程数据传输调度; 访问，审查和评估数据; 并且使用批量处理方法进行计费。

公开(公告)号：US20070213778A1

公开(公告)日：2007-09-13

申请号：US11751250

申请日：2007-05-21

申请人： John Burnes ,  Yong Cho ,  David Igel ,  Luc Mongeon ,  John Rueter ,  Harry Stone ,  Jody Zilinski

发明人： John Burnes ,  Yong Cho ,  David Igel ,  Luc Mongeon ,  John Rueter ,  Harry Stone ,  Jody Zilinski

IPC分类号： A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

摘要翻译： 用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。 在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。

公开(公告)号：US20060155338A1

公开(公告)日：2006-07-13

申请号：US11312874

申请日：2005-12-20

申请人： Luc Mongeon ,  Karen Kleckner ,  John Rueter

发明人： Luc Mongeon ,  Karen Kleckner ,  John Rueter

IPC分类号： A61N1/36

CPC分类号： A61N1/36592 ,  A61N1/3627 ,  A61N1/3684 ,  A61N1/371

摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., “CRT”). The invention also provides ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the stimulus captured. If a loss-of-capture (LOC) signal results from the capture management testing, then the applied pacing pulses are modified and the conduction test repeated. If LOC, an alert message can issue. Other aspects include: use of a trend of A-RV/LV and LV-RV timing intervals to monitor changes in the patient's heart conduction properties; bi-ventricular verification test and search—while still pacing BiV by detecting latent sense; single-V pacing threshold search, use of timing of sense in other V chamber to establish capture and LOC windows; (iv) use of a premature V pace rather than short AV interval if VV cannot be discriminated from AV; (v) option to run a threshold search only if the Bi-ventricular verification test fails.

摘要翻译： 本发明提供一种用于验证心室的起搏捕获的技术，特别是确保心室起搏方案（例如“CRT”）的期望输送。 本发明还通过递送单个心室起搏刺激并且在时间窗口期间检查心室间传导来确定是否捕获刺激来提供心室捕获管理。 如果捕获管理测试产生捕获损失（LOC）信号，则应用起搏脉冲进行修改，并重复传导测试。 如果LOC，可以发出警报消息。 其他方面包括：使用A-RV / LV和LV-RV时间间隔的趋势来监测患者心脏传导性质的变化; 通过检测潜在感觉仍然起搏BiV，双心室验证测试和搜索; 单V起搏阈值搜索，使用其他V腔中的定时定时来建立捕获和LOC窗口; （iv）如果VV不能与AV区别，则使用过早的V步速而不是短AV间隔; （v）仅当双心体验证测试失败时才能运行阈值搜索的选项。

公开(公告)号：US20060064020A1

公开(公告)日：2006-03-23

申请号：US10944982

申请日：2004-09-20

申请人： John Burnes ,  Luc Mongeon

发明人： John Burnes ,  Luc Mongeon

IPC分类号： A61B5/02

CPC分类号： A61B5/002 ,  G06F19/3418 ,  G16H10/60 ,  G16H15/00 ,  G16H40/63 ,  G16H50/30

摘要： The present invention provides a remote patient monitoring system including a graphical user interface (GUI) that displays a summary table of categorized parameter values for multiple patients simultaneously. The remote patient monitoring system further includes a central database for receiving data from remote medical devices via a communications network and a processor for parameterizing and categorizing summary data to be displayed by the GUI. The displayed summary parameter values are formatted according to category to allow a parameter value category to be visually recognized. In one embodiment, parameter values are categorized according to a need for clinical attention such that a clinician may view a summary table of categorized parameter values and recognize which patients may require clinical attention as indicated by the formatted parameter values.

摘要翻译： 本发明提供了一种远程患者监视系统，其包括图形用户界面（GUI），其同时显示多个患者的分类参数值的汇总表。 远程患者监视系统还包括用于经由通信网络从远程医疗设备接收数据的中央数据库和用于参数化和分类由GUI显示的汇总数据的处理器。 显示的摘要参数值根据类别进行格式化，以允许视觉识别参数值类别。 在一个实施例中，根据临床注意的需要对参数值进行分类，使得临床医生可以查看分类参数值的汇总表并且识别哪些患者可能需要临床注意，如格式化的参数值所示。