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公开(公告)号：US08969346B2
公开(公告)日：2015-03-03
申请号：US13642207
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/50 , C07D237/20 , C07D401/12 , C07D237/24 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , C07D401/14 , C07D405/14
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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2.发明申请公开(公告)号：US20130143862A1
公开(公告)日：2013-06-06
申请号：US13642207
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M. Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M. Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/501 , C07D401/12 , C07D413/14 , C07D513/04 , C07D487/04 , C07D405/14 , C07D417/14 , C07D401/14 , C07D409/14 , A61K31/50 , C07D237/06 , C07D403/04
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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3.发明申请公开(公告)号：US20150322018A1
公开(公告)日：2015-11-12
申请号：US14594274
申请日：2015-01-12
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： C07D237/20 , C07D413/04 , C07D401/12 , C07D513/04 , C07D401/14 , C07D417/14 , C07D409/14 , C07D403/04 , C07D401/04
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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4.发明申请CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE 有权某些氨基吡啶和氨基三氮杂，其组合物及其使用方法公开(公告)号：US20130150368A1
公开(公告)日：2013-06-13
申请号：US13642227
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D213/74 , C07D253/07 , C07D417/14 , C07D403/10 , C07D401/12 , C07D401/14 , C07D215/38 , C07D213/75
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 2，R 4，R 5，R 6，R 7，R 8，R 9，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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5.发明授权Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use 有权某些氨基吡啶和氨基三嗪，其组合物及其使用方法公开(公告)号：US09133123B2
公开(公告)日：2015-09-15
申请号：US13642227
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D253/07 , C07D401/12 , C07D401/14 , C07D417/14 , A61K31/53 , A61K31/427 , A61K31/4427 , A61P21/00 , A61P21/04 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/48 , C07D403/04 , C07D417/04 , C07D213/74 , C07D215/38 , C07D403/10
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 2，R 4，R 5，R 6，R 7，R 8，R 9，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US08962632B2
公开(公告)日：2015-02-24
申请号：US13642206
申请日：2011-04-22
申请人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： A61K31/505 , A61K31/4965 , C07D401/12 , C07D239/42 , C07D403/10 , A61K9/00 , C07D239/48 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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7.发明申请公开(公告)号：US20150315181A1
公开(公告)日：2015-11-05
申请号：US14594315
申请日：2015-01-12
申请人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： C07D417/14 , C07D401/14 , C07D401/12 , C07D403/04 , C07D239/42
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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8.发明申请公开(公告)号：US20140206709A1
公开(公告)日：2014-07-24
申请号：US14220252
申请日：2014-03-20
申请人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： C07D401/14 , A61K9/00
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US20130123289A1
公开(公告)日：2013-05-16
申请号：US13642206
申请日：2011-04-22
申请人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： C07D403/10 , C07D401/12 , C07D401/14 , C07D239/42
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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10.发明申请公开(公告)号：US20130060025A1
公开(公告)日：2013-03-07
申请号：US13612715
申请日：2012-09-12
申请人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Chihyuan Chuang , Scott Collibee , Pu-Ping Lu , Bradley Morgan , Alex Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D285/08 , C07D417/04 , C07D417/06 , C07D417/10 , C07D413/12 , C07D277/82 , C07D413/04 , C07D401/12 , C07D271/113 , C07D249/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , A61K31/428 , A61K31/4439 , C07D249/14 , C07D271/07 , C07D271/113 , C07D277/42 , C07D277/82 , C07D285/08 , C07D285/135 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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