摘要:
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要:
An I/O manager may be configured to service I/O requests pertaining to ephemeral data of a virtual machine using a storage device that is separate from and/or independent of a primary storage resource to which the I/O request is directed. Ephemeral data may be removed from ephemeral storage in response to a removal condition and/or trigger, such as a virtual machine reboot. The I/O manager may manage transfers of ephemeral virtual machine data in response to virtual machines migrating between host computing devices. The I/O manager may be further configured to cache virtual machine data, and/or manage shared file data that is common to two or more virtual machines operating on a host computing device.
摘要翻译:可以将I / O管理器配置为使用与I / O请求所针对的主存储资源分离和/或独立的存储设备来维护关于虚拟机的临时数据的I / O请求。 响应于移除条件和/或触发器(例如虚拟机重新启动),临时数据可以从临时存储器中移除。 I / O管理器可以管理临时虚拟机数据的传输,以响应在主机计算设备之间迁移的虚拟机。 I / O管理器可以被进一步配置为缓存虚拟机数据,和/或管理在主机计算设备上操作的两个或多个虚拟机通用的共享文件数据。
摘要:
Systems and methods for utilizing affinity groups to allocate data items and computing resources are disclosed. Upon receipt of a user preference indicating an affinity group, a token associated with that affinity group may be stored in a database. The affinity group may be associated with a geographic region or a number of data centers. Data items and computing resources may be associated with the affinity group. These data items and computing resources may be allocated to a geographic region or data center based on their association with the affinity group. These data items and computing resources may also be reallocated based on efficiency analyses or user preferences. In this way, data items and computing resources may be efficiently allocated with lower user effort.
摘要:
Embodiments of the present invention relate to systems, methods, and computer storage media for geographically organizing the storage of data and hosted services in a distributed computing environment. An allocation constraint is utilized to identify and select a geo-region in which an affinity group that is comprised of a hosted service and/or data is to be physically stored. Additionally, a geo-domain within the geo-region is identified for hosting the hosted service and/or data of the affinity group. A stamp, such as a storage stamp or a computation stamp, is identified on the geo-domain for storing the hosted service and/or the data. The hosted service is stored in an identified computation stamp and the data is stored in an identified storage stamp. In an additional exemplary embodiment, the identification of a geo-domain involves analyzing resource information related to potential geo-domains within a geo-region.
摘要:
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要:
The prevent invention provides an AC-DC flyback converter and a loop compensation method thereof. The AD-DC flyback converter comprises an isolating transformer, a power switch, and a feed control module. The feed control module includes a compensating circuit, a voltage buffer, and an error amplifier having a first resistor and a second resistor, and a pulse width modulation controller. With the AC-DC flyback converter and the loop compensating method, the system stability can be improved and the loop bandwidth can be reduced.
摘要:
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
摘要:
Embodiments of the present invention relate to systems, methods, and computer storage media for geographically organizing the storage of data and hosted services in a distributed computing environment. An allocation constraint is utilized to identify and select a geo-region in which an affinity group that is comprised of a hosted service and/or data is to be physically stored. Additionally, a geo-domain within the geo-region is identified for hosting the hosted service and/or data of the affinity group. A stamp, such as a storage stamp or a computation stamp, is identified on the geo-domain for storing the hosted service and/or the data. The hosted service is stored in an identified computation stamp and the data is stored in an identified storage stamp. In an additional exemplary embodiment, the identification of a geo-domain involves analyzing resource information related to potential geo-domains within a geo-region.