公开(公告)号：US12048508B2

公开(公告)日：2024-07-30

申请号：US18001009

申请日：2021-06-08

申请人： Lumeda Inc.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61B5/00 ,  A61N5/06

CPC分类号： A61B5/0059 ,  A61N5/0601 ,  A61N2005/063

摘要： An interoperative light therapy apparatus and method are disclosed. The apparatus includes an excitation light source, a plurality of light emitting devices and a plurality of light detecting fibers, wherein the plurality of light emitting devices produce a fluorescence light in cancerous cells of a patient treated with a photosensitizing medication. The fluorescence light is collected by the plurality of detector fibers and a digital spatial image of the cancerous cells is produced. The digital spatial image is useful for targeting the cancerous cells in a subsequent resection procedure. An interoperative light therapy apparatus is disclosed that further include a therapy light source that can deliver therapy light to the cancerous cells using the digital spatial image in the subsequent resection procedure.

公开(公告)号：US20230173299A1

公开(公告)日：2023-06-08

申请号：US17997942

申请日：2021-05-04

申请人： Lumeda Inc.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06 ,  A61N5/067

CPC分类号： A61N5/062 ,  A61N5/067 ,  A61N2005/063 ,  A61N2005/0628

摘要： A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source, a plurality of light emitting devices paired with a plurality of light detecting devices, wherein each of the light emitting devices is in optical communication with a channel of a delivery optical switch and each of the plurality of light detection devices is in optical communication with a channel of a detection optical switch. The plurality of light emitting devices are fixedly positioned within an applicator light flap. The system further includes an optical detector in optical communication with the detector optical switch. The system further includes an opto-electronic controller that controls delivery optical switch, the detector optical switch and the light source.

公开(公告)号：US11925814B2

公开(公告)日：2024-03-12

申请号：US17310776

申请日：2021-03-19

申请人： LUMEDA INC.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N2005/0626 ,  A61N2005/0652

摘要： A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus includes a light flap that includes a plurality of light emitting devices wherein each of the light emitting devices has a plurality of operating states. The plurality of operating states are used to train a neural network model capable of producing a treatment irradiance profile. The method includes using an image of an area of interest for targeted treatment of PDT wherein the image is used an input to the trained neural network model. The neural network model produces a plurality of optimized feature states and the apparatus in turn produces a treatment irradiance profile closely matching the area of interest.

公开(公告)号：US20230123262A1

公开(公告)日：2023-04-20

申请号：US17310776

申请日：2021-03-19

申请人： LUMEDA INC.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06

摘要： A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus includes a light flap that includes a plurality of light emitting devices wherein each of the light emitting devices has a plurality of operating states. The plurality of operating states are used to train a neural network model capable of producing a treatment irradiance profile. The method includes using an image of an area of interest for targeted treatment of PDT wherein the image is used an input to the trained neural network model. The neural network model produces a plurality of optimized feature states and the apparatus in turn produces a treatment irradiance profile closely matching the area of interest.

公开(公告)号：US20220387815A1

公开(公告)日：2022-12-08

申请号：US17594162

申请日：2021-06-08

申请人： LUMEDA INC.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06

摘要： A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source and an integrated optical applicator. The integrated optical applicator includes a plurality of light emitting devices and detector fibers fixedly spatially positioned within a flexible matrix material. The light emitting devices can be positioned a predetermined distance from an application side of the integrated optical applicator comprising an accurate and repeatable standoff position. A flexible matrix material is disclosed having a high scattering coefficient to produce a uniform irradiance pattern and predetermined fluence. A method of performing a photodynamic therapy procedure is disclosed that includes providing an integrated optical applicator couple to a therapy light source, providing a photosensitizing drug to a tissue of a patient, positioning an application side of the integrated optical applicator against a target area of the tissue, delivering a therapy light to the target area, and producing an irradiance pattern.

公开(公告)号：US11786749B2

公开(公告)日：2023-10-17

申请号：US17997942

申请日：2021-05-04

申请人： Lumeda Inc.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06 ,  A61N5/067

CPC分类号： A61N5/062 ,  A61N5/067 ,  A61N2005/0628 ,  A61N2005/063

摘要： A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source, a plurality of light emitting devices paired with a plurality of light detecting devices, wherein each of the light emitting devices is in optical communication with a channel of a delivery optical switch and each of the plurality of light detection devices is in optical communication with a channel of a detection optical switch. The plurality of light emitting devices are fixedly positioned within an applicator light flap. The system further includes an optical detector in optical communication with the detector optical switch. The system further includes an opto-electronic controller that controls delivery optical switch, the detector optical switch and the light source.

公开(公告)号：US20230408745A1

公开(公告)日：2023-12-21

申请号：US17996721

申请日：2022-06-17

申请人： Lumeda inc

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： F21V8/00 ,  H05B47/155 ,  A61N5/06

CPC分类号： G02B6/001 ,  H05B47/155 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/0652 ,  A61N2005/063

摘要： In some implementations, the device may include an optical diffuser assembly having a plurality of light emitting devices positioned along an axis adjacent to one another and the plurality of light emitting devices are adapted to be selectively addressable to produce an irradiance pattern for each of the plurality of the light emitting devices.

公开(公告)号：US20230218170A1

公开(公告)日：2023-07-13

申请号：US18001009

申请日：2021-06-08

申请人： Lumeda Inc.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61B5/00 ,  A61N5/06

CPC分类号： A61B5/0059 ,  A61N5/0601 ,  A61N2005/063

摘要： An interoperative light therapy apparatus and method are disclosed. The apparatus includes an excitation light source, a plurality of light emitting devices and a plurality of light detecting fibers, wherein the plurality of light emitting devices produce a fluorescence light in cancerous cells of a patient treated with a photosensitizing medication. The fluorescence light is collected by the plurality of detector fibers and a digital spatial image of the cancerous cells is produced. The digital spatial image is useful for targeting the cancerous cells in a subsequent resection procedure. An interoperative light therapy apparatus is disclosed that further include a therapy light source that can deliver therapy light to the cancerous cells using the digital spatial image in the subsequent resection procedure.

公开(公告)号：US11947146B2

公开(公告)日：2024-04-02

申请号：US17996721

申请日：2022-06-17

申请人： Lumeda inc

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： F21V8/00 ,  A61N5/06 ,  H05B47/155

CPC分类号： G02B6/001 ,  A61N5/062 ,  H05B47/155 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0652

摘要： In some implementations, the device may include an optical diffuser assembly having a plurality of light emitting devices positioned along an axis adjacent to one another and the plurality of light emitting devices are adapted to be selectively addressable to produce an irradiance pattern for each of the plurality of the light emitting devices.

公开(公告)号：US11666778B2

公开(公告)日：2023-06-06

申请号：US17594162

申请日：2021-06-08

申请人： LUMEDA INC.

发明人： Trevor MacDougall ,  Yi Yang

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N2005/0627 ,  A61N2005/0664

摘要： A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source and an integrated optical applicator. The integrated optical applicator includes a plurality of light emitting devices and detector fibers fixedly spatially positioned within a flexible matrix material. The light emitting devices can be positioned a predetermined distance from an application side of the integrated optical applicator comprising an accurate and repeatable standoff position. A flexible matrix material is disclosed having a high scattering coefficient to produce a uniform irradiance pattern and predetermined fluence. A method of performing a photodynamic therapy procedure is disclosed that includes providing an integrated optical applicator couple to a therapy light source, providing a photosensitizing drug to a tissue of a patient, positioning an application side of the integrated optical applicator against a target area of the tissue, delivering a therapy light to the target area, and producing an irradiance pattern.