公开(公告)号：US20200230285A1

公开(公告)日：2020-07-23

申请号：US16835662

申请日：2020-03-31

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander ,  Harald Potzschke

IPC: A61L26/00 ,  A61M1/34 ,  A61K38/42 ,  A61M35/00 ,  C07K14/805

Abstract: The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.

公开(公告)号：US11458159B2

公开(公告)日：2022-10-04

申请号：US16625566

申请日：2018-06-20

Applicant: Mölnlycke Health Care AB

Inventor： Michael Sander

IPC: A61K33/00 ,  A61K38/42

Abstract: The present invention refers to an oxygen carrier, preferably hemoglobin or myoglobin, for use in the treatment of an unpleasant feeling of a body surface due to a disease or a disorder.

公开(公告)号：US10729748B2

公开(公告)日：2020-08-04

申请号：US15056539

申请日：2016-02-29

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander

IPC: A61K38/42 ,  A61Q19/00 ,  A61K8/64 ,  A61K9/00 ,  A61L15/40 ,  A61L26/00 ,  A61L15/44 ,  A61K9/12 ,  A61K47/18

Abstract: Undue scarring of healing wounds is decreased and/or the relapse rate of wounds is lowered by applying a composition that includes hemoglobin to the wound area. At least 90% of the hemoglobin in the composition is provided in CO-charged form.

公开(公告)号：US10471175B2

公开(公告)日：2019-11-12

申请号：US15134764

申请日：2016-04-21

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander ,  Harald Potzschke

IPC: A61L26/00 ,  A61K38/42 ,  A61M35/00 ,  C07K14/805 ,  A61M1/34

Abstract: A method for preparing a composition for external treatment of wounds includes charging at least 90% of the oxygen binding sites of hemoglobin with carbon monoxide during or after isolation from its natural environment. The method further includes adding at least one further ingredient selected from the group consisting of electrolyte(s), preservative(s), stabilizer(s), anti-flocculant(s), anticoagulant(s), pH buffering agent(s), solvent(s), antioxidant(s), film-forming agent(s) and crosslinking agent(s). The method can further include packaging the composition, such as in an aerosol can.

公开(公告)号：US11116868B2

公开(公告)日：2021-09-14

申请号：US16835662

申请日：2020-03-31

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander ,  Harald Potzschke

IPC: A61L26/00 ,  A61M1/34 ,  A61K38/42 ,  A61M35/00 ,  C07K14/805

Abstract: The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.

公开(公告)号：US10960055B2

公开(公告)日：2021-03-30

申请号：US16909038

申请日：2020-06-23

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander

IPC: A61K38/42 ,  A61Q19/00 ,  A61K8/64 ,  A61K9/00 ,  A61L15/40 ,  A61L26/00 ,  A61L15/44 ,  A61K9/12 ,  A61K47/20

Abstract: Undue scarring of healing wounds is decreased and/or the relapse rate of wounds is lowered by applying a composition that includes hemoglobin to the wound area. At least 40% of the hemoglobin in the composition is provided in CO-charged form.

公开(公告)号：US20200316176A1

公开(公告)日：2020-10-08

申请号：US16909038

申请日：2020-06-23

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： Michael Sander

IPC: A61K38/42 ,  A61Q19/00 ,  A61K8/64 ,  A61K9/00 ,  A61L15/40 ,  A61L26/00 ,  A61L15/44 ,  A61K9/12 ,  A61K47/20

Abstract: Undue scarring of healing wounds is decreased and/or the relapse rate of wounds is lowered by applying a composition that includes hemoglobin to the wound area. At least 40% of the hemoglobin in the composition is provided in CO-charged form.