公开(公告)号：US20170081372A1

公开(公告)日：2017-03-23

申请号：US15017486

申请日：2016-02-05

Applicant: MERIAL INC.

Inventor： Laurent Bernard Fischer ,  Nicolas Pierre Yves Carboulec ,  Fabien Lux

IPC: C07K14/44 ,  C12N9/50 ,  A61K39/008 ,  C12N9/10

CPC classification number: C07K14/245 ,  A23L3/0155 ,  A61K39/008 ,  A61K39/0225 ,  A61K39/0241 ,  A61K39/099 ,  A61K2039/552 ,  A61L2/0011 ,  C07K14/44 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/40 ,  C12N5/0031 ,  C12N9/1007 ,  C12N9/50 ,  C12N9/52 ,  C12P21/02 ,  C12Y201/01041 ,  C12Y304/22

Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.