公开(公告)号：US20150374808A1

公开(公告)日：2015-12-31

申请号：US14699296

申请日：2015-04-29

申请人： MERIAL INC.

发明人： Laurent Bernard Fischer

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

摘要： The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

摘要翻译： 该申请公开了基于表达编码大鼠Her2蛋白的基因的“pING”DNA质粒载体的治疗性疫苗。 根据本公开的疫苗被用作用于具有过表达Her2抗原的癌症的狗和猫的手术，放射和/或化学疗法的辅助治疗，并且延长了手术后无疾病间隔和/或存活时间。 还包括使用所述疫苗的治疗有效的免疫方法。

公开(公告)号：US09901628B2

公开(公告)日：2018-02-27

申请号：US14699296

申请日：2015-04-29

申请人： MERIAL INC.

发明人： Laurent Bernard Fischer

IPC分类号： A61K39/00 ,  A61K48/00

CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

摘要： The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

公开(公告)号：US20170081372A1

公开(公告)日：2017-03-23

申请号：US15017486

申请日：2016-02-05

申请人： MERIAL INC.

发明人： Laurent Bernard Fischer ,  Nicolas Pierre Yves Carboulec ,  Fabien Lux

IPC分类号： C07K14/44 ,  C12N9/50 ,  A61K39/008 ,  C12N9/10

CPC分类号： C07K14/245 ,  A23L3/0155 ,  A61K39/008 ,  A61K39/0225 ,  A61K39/0241 ,  A61K39/099 ,  A61K2039/552 ,  A61L2/0011 ,  C07K14/44 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/40 ,  C12N5/0031 ,  C12N9/1007 ,  C12N9/50 ,  C12N9/52 ,  C12P21/02 ,  C12Y201/01041 ,  C12Y304/22

摘要： The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.