公开(公告)号：US09730987B2

公开(公告)日：2017-08-15

申请号：US14632863

申请日：2015-02-26

申请人： MERIAL INC.

发明人： Noel Joseph Francois Detraz ,  Guillaume Rigaut

IPC分类号： A61K39/00 ,  A61K47/26 ,  A61K9/00 ,  A61K9/107 ,  A61K45/06 ,  A61K47/06 ,  C12N7/00 ,  A61K39/39 ,  A61K39/02 ,  A61K39/12 ,  A61K39/135 ,  A61K39/125

CPC分类号： A61K39/00 ,  A61K9/0019 ,  A61K9/107 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/125 ,  A61K39/135 ,  A61K39/39 ,  A61K45/06 ,  A61K47/06 ,  A61K47/26 ,  A61K2039/52 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N7/00 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/10034 ,  C12N2770/32022 ,  C12N2770/32134

摘要： The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.