公开(公告)号：US09730987B2

公开(公告)日：2017-08-15

申请号：US14632863

申请日：2015-02-26

Applicant: MERIAL INC.

Inventor： Noel Joseph Francois Detraz ,  Guillaume Rigaut

IPC: A61K39/00 ,  A61K47/26 ,  A61K9/00 ,  A61K9/107 ,  A61K45/06 ,  A61K47/06 ,  C12N7/00 ,  A61K39/39 ,  A61K39/02 ,  A61K39/12 ,  A61K39/135 ,  A61K39/125

CPC classification number: A61K39/00 ,  A61K9/0019 ,  A61K9/107 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/125 ,  A61K39/135 ,  A61K39/39 ,  A61K45/06 ,  A61K47/06 ,  A61K47/26 ,  A61K2039/52 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N7/00 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/10034 ,  C12N2770/32022 ,  C12N2770/32134

Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.

公开(公告)号：US20170296577A1

公开(公告)日：2017-10-19

申请号：US15487323

申请日：2017-04-13

Applicant: MERIAL INC. ,  GENZYME CORPORATION

Inventor： Guillaume Rigaut ,  Celine Loss-Dunod ,  Alexis Guy Andre Lucien Parisot ,  Pradeep K. Dahl

IPC: A61K31/787 ,  A61K39/12 ,  A61K31/444 ,  A61K39/04 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates to non-mercurial preservatives, including antimicrobial polyamide polymers and octenidine, and to methods of use thereof to produce preservative-containing multi-dose formulations. The preservative-containing multi-dose formulations exhibit resistance to one or more contaminating microorganisms, and have advantageous properties with respect to long term stability of biological and small molecule active ingredients.

公开(公告)号：US20170360923A1

公开(公告)日：2017-12-21

申请号：US15624405

申请日：2017-06-15

Applicant: MERIAL INC. ,  SANOFI PASTEUR

Inventor： Guillaume Rigaut ,  Alexis Guy André Lucien Parisot ,  Karelle De Luca ,  Christine Michele Pierrette Andreoni ,  Lydie Remolue ,  Marie Garinot ,  Jean-François Cotte ,  Patricia Probeck-Quellec ,  Jean Haensler ,  Véronique Chambon ,  Philippe Talaga

IPC: A61K39/39 ,  A61K47/26 ,  A61K39/00 ,  A61K47/08

Abstract: The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. The immunogens may include, but are not limited to: inactivated pathogens, attenuated pathogens, subunits, recombinant expression vectors, plasmids or combinations thereof. The animals may include, but are not limited to: humans, murine, canines, felines, equines, porcines, ovines, caprines and bovines.