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公开(公告)号：US08580765B2
公开(公告)日：2013-11-12
申请号：US13609614
申请日：2012-09-11
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US08334270B2
公开(公告)日：2012-12-18
申请号：US13099671
申请日：2011-05-03
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US08716262B2
公开(公告)日：2014-05-06
申请号：US12645765
申请日：2009-12-23
CPC分类号： C07H19/20
摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。
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公开(公告)号：US20130029929A1
公开(公告)日：2013-01-31
申请号：US13609614
申请日：2012-09-11
IPC分类号： C07H19/06 , A61P31/16 , A61P31/14 , A61K31/7072 , C07H1/00
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US08716263B2
公开(公告)日：2014-05-06
申请号：US12645821
申请日：2009-12-23
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US20120316327A1
公开(公告)日：2012-12-13
申请号：US13491437
申请日：2012-06-07
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
IPC分类号： C07H1/00 , C07H19/20 , C07H19/213 , C07H15/207
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US08173621B2
公开(公告)日：2012-05-08
申请号：US12479075
申请日：2009-06-05
申请人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
发明人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure:
摘要翻译： 用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：
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公开(公告)号：US08759510B2
公开(公告)日：2014-06-24
申请号：US13439991
申请日：2012-04-05
申请人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
发明人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure:
摘要翻译： 用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：
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公开(公告)号：US08563530B2
公开(公告)日：2013-10-22
申请号：US13076718
申请日：2011-03-31
申请人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
发明人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
CPC分类号： A61K31/7076 , C07H19/207
摘要： Disclosed herein is a compound represented by formula 1 or its hydrate thereof in crystalline or crystal-like form.
摘要翻译： 本文公开了结晶或晶体形式的由式1表示的化合物或其水合物。
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