公开(公告)号：US11850291B2

公开(公告)日：2023-12-26

申请号：US16663387

申请日：2019-10-25

申请人： Ming-Hsin Li ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

发明人： Ming-Hsin Li ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

IPC分类号： A61K51/08

CPC分类号： A61K51/088

摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

公开(公告)号：US20210121585A1

公开(公告)日：2021-04-29

申请号：US16663387

申请日：2019-10-25

申请人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

发明人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

IPC分类号： A61K51/08

摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

公开(公告)号：US11077217B2

公开(公告)日：2021-08-03

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：US20200237938A1

公开(公告)日：2020-07-30

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga, 67Ga, 68Ga, 177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：US20110158903A1

公开(公告)日：2011-06-30

申请号：US12650793

申请日：2009-12-31

申请人： SHU-PEI CHIU ,  Te-Wei Lee ,  Chia-Yu Yu ,  Su-Jung Chen ,  Chung-Li Ho ,  Wei-Chuan Hsu ,  Ya-Jen Chang

发明人： SHU-PEI CHIU ,  Te-Wei Lee ,  Chia-Yu Yu ,  Su-Jung Chen ,  Chung-Li Ho ,  Wei-Chuan Hsu ,  Ya-Jen Chang

IPC分类号： A61K51/12 ,  A61P35/00

CPC分类号： A61K51/1234 ,  A61K47/543 ,  A61K47/60

摘要： One pot process of preparing multifunctional liposome drug is provided. In this one pot process, liposome reacted with radionuclide labeled solution, chemotherapy drug, and targeted ligand at appropriate temperature. The product in this invention for preparation multifunctional liposome drugs in for imaging, delivery and targeting in cancer diagnosis and therapy has proved to be more simple, convenient, effective and easier than the prior art is.

摘要翻译： 提供了制备多功能脂质体药物的一锅法。 在这一锅法中，脂质体与放射性核素标记溶液，化疗药物和靶向配体在合适的温度下反应。 本发明中用于制备用于癌症诊断和治疗中的成像，递送和靶向的多功能脂质体药物的产品被证明比现有技术更简单，方便，有效和更容易。

公开(公告)号：US09295740B2

公开(公告)日：2016-03-29

申请号：US13538105

申请日：2012-06-29

申请人： Chia-Yu Yu ,  Te-Wei Lee ,  Su-Jung Chen ,  Liang-Cheng Chen ,  Chien-Hong Lin

发明人： Chia-Yu Yu ,  Te-Wei Lee ,  Su-Jung Chen ,  Liang-Cheng Chen ,  Chien-Hong Lin

IPC分类号： A61K51/08 ,  A61K51/12

CPC分类号： A61K51/081 ,  A61K51/1251

摘要： The present invention relates to a method for preparing 186/188Re-labeled human serum albumin (HSA) microspheres by 186/188Re(I)-tricarbonyl ion. This radioactive particle can be subjected to radioembolization for liver tumor. In this method, 186/188Re(I)-tricarbonyl ion (186/188Re(OH2)3(CO)3)+) are employed as a precursor for directly labeling HSA microspheres with 186/188Re at appropriate temperature.

摘要翻译： 本发明涉及通过186 / 188Re（I） - 三羰基离子制备186 / 188Re标记的人血清白蛋白（HSA）微球的方法。 该放射性粒子可以进行肝肿瘤的放射线栓塞。 在该方法中，使用186 / 188Re（I） - 三羰基离子（186 / 188Re（OH 2）3（CO）3）+）作为在适当温度下用186 / 188Re直接标记HSA微球的前体。