公开(公告)号：US20090060949A1

公开(公告)日：2009-03-05

申请号：US12011032

申请日：2008-01-23

申请人： David D. Ho ,  Yaoxing Huang ,  Ming Wei Chen ,  Rachel T.J. Cheng ,  Chi-Huey Wong ,  Alice Yu

发明人： David D. Ho ,  Yaoxing Huang ,  Ming Wei Chen ,  Rachel T.J. Cheng ,  Chi-Huey Wong ,  Alice Yu

IPC分类号： A61K39/145 ,  C07H21/04 ,  C07K14/00 ,  C07K16/08 ,  A61P37/04 ,  C12N15/09 ,  C12N15/64 ,  A61K31/711

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/53 ,  A61K2039/58 ,  C12N2760/16122 ,  C12N2760/16134

摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.

摘要翻译： 本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

公开(公告)号：US06577656B2

公开(公告)日：2003-06-10

申请号：US09923471

申请日：2001-08-06

申请人： John Ming-wei Chen ,  Robert K. Shih

发明人： John Ming-wei Chen ,  Robert K. Shih

IPC分类号： H01S304

CPC分类号： H01S5/02212 ,  H01L2224/48091 ,  H01S5/02268 ,  H01S5/0683 ,  H01L2924/00014

摘要： The present invention relates generally to laser/detector packages, and particularly to laser/detector packages with components that increase the accuracy and ease of laser diode positioning. In particular, the laser/detector package of the present invention includes an attachment plate having a reference surface; a header post that is perpendicular to the reference surface when attached to the reference surface; sub-mount that houses a laser diode and abuts the reference surface or a spacer, which abuts the reference surface. By abutting the reference surface or the spacer, the laser diode attached to the sub-mount is easily and precisely positioned a proper distance from the reference surface. Additionally, preferred embodiments of the invention include a marking on the sub-mount that is parallel to the reference surface and a marking that is perpendicular to the reference surface on the spacer or sub-mount. These markings further improve the ease and accuracy of positioning and repositioning the laser diode and/or sub-mount.

公开(公告)号：US11077217B2

公开(公告)日：2021-08-03

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：US07981428B2

公开(公告)日：2011-07-19

申请号：US12417556

申请日：2009-04-02

申请人： Chi-Huey Wong ,  David D. Ho ,  Yaoxing Huang ,  Ting-Jen R. Cheng ,  Ming Wei Chen ,  Alice Yu

发明人： Chi-Huey Wong ,  David D. Ho ,  Yaoxing Huang ,  Ting-Jen R. Cheng ,  Ming Wei Chen ,  Alice Yu

IPC分类号： A61K39/145 ,  A61K48/00 ,  C12N15/44 ,  C12N7/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C07K16/1018 ,  C07K2317/76 ,  C12N2760/16122 ,  C12N2760/16134

摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.

摘要翻译： 本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

公开(公告)号：US20210121585A1

公开(公告)日：2021-04-29

申请号：US16663387

申请日：2019-10-25

申请人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

发明人： MING-HSIN LI ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

IPC分类号： A61K51/08

摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

公开(公告)号：US20200237938A1

公开(公告)日：2020-07-30

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga, 67Ga, 68Ga, 177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：US20200078478A1

公开(公告)日：2020-03-12

申请号：US16125787

申请日：2018-09-10

申请人： Ming-Hsin Li ,  Ming-Wei Chen ,  Shin-Min Wang ,  Shih-Wei Lo ,  Chun-Fang Feng ,  Cheng-Hui Chuang ,  Sheng-Nan Lo

发明人： Ming-Hsin Li ,  Ming-Wei Chen ,  Shin-Min Wang ,  Shih-Wei Lo ,  Chun-Fang Feng ,  Cheng-Hui Chuang ,  Sheng-Nan Lo

IPC分类号： A61K51/04

摘要： A PSMA targeting peptide derivative for radiotherapy, which is a structural molecule developed for diagnosis or treatment of prostate cancer, as prostate-specific membrane antigen (PSMA) is a protein present on the surface of healthy prostate cells, which is often at a high level of expression on the surface of prostate cancer cells, and the molecular composition of PSMA inhibitor is mainly composed of glutamic acid, urea and lysine, in addition to the linker of the present invention, PSMA inhibitor can be combined with a chelating agent and truncated Evans Blue, which can be labeled with radionuclides Ga-67, Ga-68, In-111, Lu-177, Cu-64 or Y-90, used for image analysis and analysis of human prostate cancer tumor pattern as a new PSMA targeting peptide receptor radionuclide therapy (PRRT), and which has a longer half-life in vivo and is featured by specific binding of PSMA for radiotherapy diagnosis or treatment.

公开(公告)号：US08030029B2

公开(公告)日：2011-10-04

申请号：US12011032

申请日：2008-01-23

申请人： David D. Ho ,  Yaoxing Huang ,  Ming Wei Chen ,  Rachel TJ Cheng ,  Chi-Huey Wong ,  Alice Yu

发明人： David D. Ho ,  Yaoxing Huang ,  Ming Wei Chen ,  Rachel TJ Cheng ,  Chi-Huey Wong ,  Alice Yu

IPC分类号： C12N15/44 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/53 ,  A61K2039/58 ,  C12N2760/16122 ,  C12N2760/16134

摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.

公开(公告)号：USD570097S1

公开(公告)日：2008-06-03

申请号：US29260894

申请日：2006-06-05

申请人： Ming-Wei Chen

设计人： Ming-Wei Chen

公开(公告)号：US20220089574A1

公开(公告)日：2022-03-24

申请号：US17027748

申请日：2020-09-22

申请人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

发明人： MING-HSIN LI ,  SHENG-NAN LO ,  SHIH-WEI LO ,  SHIH-YING LEE ,  SU-JUNG CHEN ,  WEI-LIN LO ,  MING-WEI CHEN ,  YUAN-RUEI HUANG

IPC分类号： C07D403/12 ,  C07F5/00

摘要： The structure and preparation method of a compound D-L2(-B)-L1-A is disclosed, A is a physiologically and pharmacologically active molecule that physically binds to a specific biological molecule or receptor; L1 is a variable structure with the molecular connection activity at both ends connecting to A and L2; L2 is a variable structure, which has three-terminal molecular connection activity connecting to L1, D and B; B is a physiologically and pharmacologically active molecule that binds to albumin, changing the A molecule in the body cyclic characteristics; D is a polycarboxylic macrocyclic structure that binds to radioisotopes; D-L2(-B)-L1-A compound can be used to express chemokine receptor 4 (CXCR4) receptors on cells, tissues, and/or organs, and after binding with radionuclides, it is suitable for detection of CXCR4 protein binding in vitro, detection of CXCR4 cell binding in vitro or detection of CXCR4 expression in in vivo animal imaging.