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公开(公告)号：US20240350711A1
公开(公告)日：2024-10-24
申请号：US18684928
申请日：2022-08-24
申请人： MOCHIDA PHARMACEUTICAL CO., LTD. , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY , KONAN GAKUEN
CPC分类号： A61L27/3834 , A61L27/20 , A61L27/386 , A61L27/52 , A61L2400/06 , A61L2430/10
摘要： It is desirable to provide a novel biomaterial and the like for tendon repair. Provided is a biomaterial for tendon repair containing a hydrogel formed by means of a cross-linking reaction between a reactive group A and a reactive group B, wherein the hydrogel contains a water-soluble polymer having the reactive group A, and mesenchymal stem cells having the reactive group B.
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公开(公告)号：US20230080690A1
公开(公告)日：2023-03-16
申请号：US17792076
申请日：2021-01-15
发明人： Norimasa IWASAKI , Tomohiro ONODERA , Atsushi URITA , Ryo JO
IPC分类号： A61K35/28 , A61P19/02 , A61K31/734
摘要： Provided is a composition for treating cartilage injury lesion that is combined with a concentrated bone marrow aspirate and applied to a cartilage injury lesion, that has flowability when applied to the cartilage injury lesion, and that contains a monovalent metal salt of alginic acid. Thereby, a novel composition for treating cartilage injury lesion that can be used to restore and/or regenerate cartilage tissue is provided.
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公开(公告)号：US20200030367A1
公开(公告)日：2020-01-30
申请号：US16489436
申请日：2018-03-01
IPC分类号： A61K31/734 , A61K9/00 , A61K9/19 , A61P19/04
摘要： The present invention has an objective of providing a novel composition for treating a fibrocartilaginous tissue injury. The present invention provides a composition for treating a fibrocartilaginous tissue injury, which is to be applied to an injured fibrocartilaginous tissue part of a target and which comprises a monovalent metal salt of alginic acid, more preferably a low endotoxin monovalent metal salt of alginic acid.
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公开(公告)号：US20230045844A1
公开(公告)日：2023-02-16
申请号：US17792099
申请日：2021-01-13
发明人： Tomokazu TAKAI , Hitoshi MIZUNO , Akira TAKAHASHI , Toshiya ENDO , Shinichi SAKAUE , Norimasa IWASAKI , Tomohiro ONODERA , Koji IWASAKI
IPC分类号： A61K31/734 , A61K9/06 , A61L27/20 , A61L27/52 , A61P19/04
摘要： Realized is reliable fixation of a material in a fluid state containing a monovalent metal salt of alginic acid when the material is applied to a subject. A combination of compositions comprising a first material composition containing a monovalent metal salt of alginic acid and a second material composition containing a cross-linking agent having an action of cross-linking the monovalent metal salt of alginic acid, wherein the combination is to be used in such a way as to apply the first material composition to a subject in a fluid state and contact the second material composition with the first material composition applied to the subject to gel at least a part of the first material composition, wherein the first material composition further contains a coloring component so that a formation state of a gel coat on a surface of the first material composition applied to the subject can be evaluated.
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公开(公告)号：US20230041137A1
公开(公告)日：2023-02-09
申请号：US17792028
申请日：2021-01-13
发明人： Hitoshi MIZUNO , Kuniyoshi MASUDA , Masahiko KATAYAMA , Tomokazu TAKAI , Toshiya ENDO , Norimasa IWASAKI , Tomohiro ONODERA , Koji IWASAKI
IPC分类号： A61B17/02
摘要： A retractor is provided that can form a joint cavity internal space for a field of view for an endoscope and practice of a treatment in a state where a wound area is spread. A retractor includes first arm portions 2 and 3 and a second arm portion 4 positioned between the first arm portions 2 and 3. The first arm portions 2 and 3 include first claw portions 12 and 13 to be hung on a wound area entrance edge. The second arm portion 4 includes a second claw portion 14 to be hung on the wound area entrance edge. When the first arm portions 2 and 3 and the second arm portion 4 are in a closed state, the first claw portions 12 and 13 and the second claw portion 14 overlap with each other.
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公开(公告)号：US20200289547A1
公开(公告)日：2020-09-17
申请号：US16086081
申请日：2017-01-27
IPC分类号： A61K31/734 , A61F2/44 , A61K9/19
摘要： The present invention provides a composition for filling the nucleus pulposus of an intervertebral disc, the composition containing a low endotoxin monovalent metal salt of alginic acid. The composition is applied to a nucleus pulposus site of a subject, is used so as to be cured partially after application, and has fluidity when applied to the nucleus pulposus site. Accordingly, a composition for filling nucleus pulposus is provided, the composition being capable of promoting the regeneration of the nucleus pulposus of an intervertebral disc.
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公开(公告)号：US20160067309A1
公开(公告)日：2016-03-10
申请号：US14944357
申请日：2015-11-18
发明人： Norimasa IWASAKI , Atsushi SUKEGAWA , Akio MINAMI , Nobuo OHZAWA
IPC分类号： A61K38/19 , A61K31/734
CPC分类号： A61K38/195 , A61K31/734 , A61L27/20 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/04
摘要： A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.
摘要翻译： 已经需要用于再生软骨的新型组合物，其可以实现再生几乎正常软骨的透明软骨的良好效果，而不需要使用任何移植的细胞。 本发明提供一种用于再生软骨的组合物，其中（a）低内毒素海藻酸的一价金属盐和（b）SDF-1的组合使用。
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8.发明公开公开(公告)号：US20240066152A1
公开(公告)日：2024-02-29
申请号：US18250591
申请日：2021-10-28
摘要： The present invention provides: an MRI contrast agent for detecting cartilage damage, which comprises 17O-labeled water; and a method and a program for detecting cartilage damage using the contrast agent. According to the present invention, it becomes possible to detect a damage in a cartilage, particularly a minor damage in the surface layer of a cartilage which has been difficult to detect so far, by using 17O-labeled water as a contrast agent.
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