公开(公告)号：US20190002893A1

公开(公告)日：2019-01-03

申请号：US16023525

申请日：2018-06-29

申请人： MODERN MEADOW, INC.

发明人： Lixin Dai ,  Julia Borden ,  Jeffrey Nelson ,  Kristin Ruebling-Jass

IPC分类号： C12N15/81 ,  C07K14/78 ,  D01F4/00 ,  D06N3/00

摘要： Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.

公开(公告)号：US11028146B2

公开(公告)日：2021-06-08

申请号：US16125386

申请日：2018-09-07

申请人： MODERN MEADOW, INC.

发明人： Lixin Dai ,  Kristin Ruebling-Jass ,  David Thomas Williamson

IPC分类号： C12N9/96 ,  C07K14/78 ,  D01F4/00 ,  C07K14/195 ,  C07K14/245 ,  C12N9/02 ,  C12N15/81 ,  C12N9/04 ,  C12N9/12 ,  C12N9/18 ,  C12N9/90 ,  C12R1/84 ,  D01F1/02

摘要： This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.

公开(公告)号：US11312968B2

公开(公告)日：2022-04-26

申请号：US16023525

申请日：2018-06-29

申请人： MODERN MEADOW, INC.

发明人： Lixin Dai ,  Julia Borden ,  Jeffrey Nelson ,  Kristin Ruebling-Jass

IPC分类号： C12Q1/68 ,  C12N15/81 ,  C07K14/78 ,  C12P21/02 ,  C08J3/24 ,  C12N1/16 ,  C12N1/18 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/85 ,  D01F4/00 ,  D06N3/00 ,  C12N9/02 ,  C12N15/10

摘要： Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.

公开(公告)号：US20190093116A1

公开(公告)日：2019-03-28

申请号：US16125386

申请日：2018-09-07

申请人： MODERN MEADOW, INC.

发明人： Lixin Dai ,  Kristin Ruebling-Jass ,  David Thomas Williamson

IPC分类号： C12N15/81 ,  C12N9/02 ,  C07K14/78

摘要： This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.