公开(公告)号：US10301440B2

公开(公告)日：2019-05-28

申请号：US15433777

申请日：2017-02-15

Applicant: MODERN MEADOW, INC.

Inventor： Brendan Patrick Purcell ,  David Thomas Williamson ,  Lixin Dai ,  Darryl Miles Cassingham ,  Stephen M. Spinella

IPC: D06M15/15 ,  C08J3/24 ,  C14C13/00 ,  D04H13/00 ,  D06P3/32 ,  C07K14/78 ,  C14C9/00 ,  C14C9/02 ,  D04H1/4382 ,  D01C3/00 ,  D06N3/00 ,  D04H1/00 ,  D06M15/05 ,  D01F4/00 ,  B32B5/26 ,  D06N7/00 ,  B32B5/02 ,  B32B7/12 ,  B32B9/02 ,  B32B15/02 ,  B32B15/14 ,  B32B23/10 ,  B32B27/12 ,  B32B29/02 ,  B32B1/08 ,  B32B3/26 ,  D06M101/06 ,  D06M23/16

Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).

公开(公告)号：US11214844B2

公开(公告)日：2022-01-04

申请号：US16189692

申请日：2018-11-13

Applicant: MODERN MEADOW, INC.

Inventor： Brendan Patrick Purcell ,  Suzanne Lee ,  Lixin Dai ,  Katherine Amy Congdon ,  Stephen M. Spinella ,  Chi Man Ng

IPC: C14B7/04 ,  C14C7/00 ,  C14C13/00 ,  C08H1/06 ,  C08L89/06 ,  D06N3/00 ,  D06N3/12

Abstract: The invention herein provides biofabricated materials having zonal properties and methods of making biofabricated materials having zonal properties.

公开(公告)号：US11384135B2

公开(公告)日：2022-07-12

申请号：US16125320

申请日：2018-09-07

Applicant: MODERN MEADOW, INC.

Inventor： Lixin Dai ,  Poonam Srivastava

IPC: C12P1/00 ,  C07K14/78 ,  D01F4/00 ,  C07K14/195 ,  C07K14/245 ,  C12N1/16 ,  C12N9/02 ,  C12N15/81 ,  C12N9/04 ,  C12N9/12 ,  C12N9/18 ,  C12N9/90 ,  D01F1/02 ,  C12R1/84

Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.

公开(公告)号：US20190002893A1

公开(公告)日：2019-01-03

申请号：US16023525

申请日：2018-06-29

Applicant: MODERN MEADOW, INC.

Inventor： Lixin Dai ,  Julia Borden ,  Jeffrey Nelson ,  Kristin Ruebling-Jass

IPC: C12N15/81 ,  C07K14/78 ,  D01F4/00 ,  D06N3/00

Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.

公开(公告)号：US11312968B2

公开(公告)日：2022-04-26

申请号：US16023525

申请日：2018-06-29

Applicant: MODERN MEADOW, INC.

Inventor： Lixin Dai ,  Julia Borden ,  Jeffrey Nelson ,  Kristin Ruebling-Jass

IPC: C12Q1/68 ,  C12N15/81 ,  C07K14/78 ,  C12P21/02 ,  C08J3/24 ,  C12N1/16 ,  C12N1/18 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/85 ,  D01F4/00 ,  D06N3/00 ,  C12N9/02 ,  C12N15/10

Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.

公开(公告)号：US11001679B2

公开(公告)日：2021-05-11

申请号：US16358299

申请日：2019-03-19

Applicant: MODERN MEADOW, INC.

Inventor： Brendan Patrick Purcell ,  David Thomas Williamson ,  Lixin Dai ,  Darryl Miles Cassingham ,  Stephen M. Spinella

IPC: D06M15/15 ,  C08J3/24 ,  D01F4/00 ,  B32B5/26 ,  D06N3/00 ,  D06N7/00 ,  B32B5/02 ,  B32B7/12 ,  B32B9/02 ,  B32B15/02 ,  B32B15/14 ,  B32B23/10 ,  B32B27/12 ,  B32B29/02 ,  B32B1/08 ,  B32B3/26 ,  C14C13/00 ,  D04H13/00 ,  D06P3/32 ,  C07K14/78 ,  C14C9/00 ,  C14C9/02 ,  D04H1/4382 ,  D01C3/00 ,  D04H1/00 ,  D06M15/05 ,  D06M23/16 ,  D06M101/06

Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).

公开(公告)号：US20190093116A1

公开(公告)日：2019-03-28

申请号：US16125386

申请日：2018-09-07

Applicant: MODERN MEADOW, INC.

Inventor： Lixin Dai ,  Kristin Ruebling-Jass ,  David Thomas Williamson

IPC: C12N15/81 ,  C12N9/02 ,  C07K14/78

Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.

公开(公告)号：US11530304B2

公开(公告)日：2022-12-20

申请号：US15433566

申请日：2017-02-15

Applicant: MODERN MEADOW, INC.

Inventor： Brendan Patrick Purcell ,  David Thomas Williamson ,  Lixin Dai ,  Darryl Miles Cassingham ,  Stephen M. Spinella ,  Katherine Amy Congdon

IPC: B32B5/26 ,  D06N3/00 ,  D06N7/00 ,  C08J3/24 ,  D01F4/00 ,  D06M15/15 ,  B32B5/02 ,  B32B7/12 ,  B32B9/02 ,  B32B15/02 ,  B32B15/14 ,  B32B23/10 ,  B32B27/12 ,  B32B29/02 ,  B32B1/08 ,  B32B3/26 ,  D04H1/4382 ,  C14C13/00 ,  D04H13/00 ,  D06P3/32 ,  C07K14/78 ,  C14C9/00 ,  C14C9/02 ,  D01C3/00 ,  D04H1/00 ,  D06M15/05 ,  D06M23/16 ,  D06M101/06

Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).

公开(公告)号：US20210355326A1

公开(公告)日：2021-11-18

申请号：US17246044

申请日：2021-04-30

Applicant: Modern Meadow, Inc.

Inventor： Samuel BROADBENT ,  Dale L. HANDLIN, JR. ,  Shaobo CAI ,  Zhe TAN ,  Casey CROWNHART ,  Nicholas YARAGHI ,  David WILLIAMSON ,  Alexander Iain NORMAN ,  Lixin Dai

IPC: C08L89/06 ,  C08L75/04

Abstract: Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.

公开(公告)号：US11028146B2

公开(公告)日：2021-06-08

申请号：US16125386

申请日：2018-09-07

Applicant: MODERN MEADOW, INC.

Inventor： Lixin Dai ,  Kristin Ruebling-Jass ,  David Thomas Williamson

IPC: C12N9/96 ,  C07K14/78 ,  D01F4/00 ,  C07K14/195 ,  C07K14/245 ,  C12N9/02 ,  C12N15/81 ,  C12N9/04 ,  C12N9/12 ,  C12N9/18 ,  C12N9/90 ,  C12R1/84 ,  D01F1/02

Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.