公开(公告)号：US20130244972A1

公开(公告)日：2013-09-19

申请号：US13830268

申请日：2013-03-14

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Noah Ben-Shalom ,  Zvi Nevo ,  Abraham Patchornik ,  Dror Robinson

IPC: A61K47/36 ,  A61K31/738 ,  A61L26/00

CPC classification number: A61K31/722 ,  A61K8/042 ,  A61K8/736 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/738 ,  A61K47/36 ,  A61K2800/594 ,  A61K2800/805 ,  A61K2800/91 ,  A61L26/0023 ,  A61L26/008 ,  A61L26/009 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/52 ,  A61L27/60 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/06 ,  A61Q19/00 ,  A61Q19/08 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08 ,  C08L2666/26 ,  A61L15/28

Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.