公开(公告)号：US3882111A

公开(公告)日：1975-05-06

申请号：US36749773

申请日：1973-06-06

申请人： MORTON NORWICH PRODUCTS INC

发明人： WRIGHT GEORGE C ,  BAYLESS ALLAN V ,  GRAY JOSEPH E

IPC分类号： A61K31/53 ,  A61P31/04 ,  C07D471/04 ,  C07D57/34

CPC分类号： C07D471/04

摘要： The titled compounds are effective antifungal agents adapted to be combined in pharmaceutical forms for use in the eradication of fungus infection.

摘要翻译： 标题化合物是适于以药物形式组合用于根除真菌感染的有效抗真菌剂。

公开(公告)号：US3919231A

公开(公告)日：1975-11-11

申请号：US56086975

申请日：1975-03-21

申请人： MORTON NORWICH PRODUCTS INC

发明人： PELOSI JR STANFORD S ,  WHITE RONALD E ,  WHITE JR RALPH L ,  WRIGHT GEORGE C ,  YOU CHIA-NIEN

IPC分类号： C07D307/46 ,  C07D307/52 ,  C07D307/68 ,  C07D239/26 ,  C07D307/54

CPC分类号： C07D307/68 ,  C07D307/46 ,  C07D307/52

摘要： wherein A is 5-chloro-2-pyrimidinyl or
WITH X representing hydrogen, nitro, amino, halo, dihalo, 4(lower)alkyl, 3-trifluoromethyl, 3,4-dimethoxy, 4-methyl-3chloro,4-alkoxy, 4-dimethylamino, 4-ethoxycarbonyl, 4-hydroxy, 4methyl thio, 4-(1-hydroxy)ethyl, or 4-acetyl, and R represents hydrogen or ethyl. These compounds are useful as antidepressants. Their useful antidepressant activity is exhibited in warm blooded animals under the standard ptosis-anti-tetrabenazine test. Thus, when administered perorally in suspension (0.5% aqueous methyl cellulose) or aqueous solution in doses ranging from 50 to 200 mg/kg to mice shortly prior to intraperitoneal administration of from 1-10 mg/kg of tetrabenazine, ptosis induced by tetrabenazine is curtailed to the extent of from 50-100%.

A series of 5-aryl-2-furamidines are useful as antidepressants. This invention is concerned with a series of 5-aryl-2furamidines of the formula:

摘要翻译： 一系列5-芳基-2-糠酰胺可用作抗抑郁药。

公开(公告)号：US3906010A

公开(公告)日：1975-09-16

申请号：US47983074

申请日：1974-06-17

申请人： MORTON NORWICH PRODUCTS INC

发明人： PELOSI JR STANFORD S ,  WHITE RONALD E ,  WHITE JR RALPH L ,  WRIGHT GEORGE C ,  YOU CHIA-NIEN

IPC分类号： C07D307/46 ,  C07D307/52 ,  C07D307/68 ,  C07D405/04 ,  C07D5/16

CPC分类号： C07D307/68 ,  C07D307/46 ,  C07D307/52

摘要： A series of 5-aryl-2-furamidines are useful as antidepressants.

公开(公告)号：US3883526A

公开(公告)日：1975-05-13

申请号：US36750073

申请日：1973-06-06

申请人： MORTON NORWICH PRODUCTS INC

发明人： WRIGHT GEORGE C ,  BAYLESS ALLAN V ,  GRAY JOSEPH E

IPC分类号： C07D213/77 ,  C07D471/04 ,  C07D57/34

CPC分类号： C07D213/77 ,  C07D471/04

摘要： The titled compounds are effective antifungal agents adapted to be combined in pharmaceutical forms for use in the eradication of fungus infections.

摘要翻译： 标题化合物是适用于以药物形式组合用于根除真菌感染的有效抗真菌剂。