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    OPTICAL COHERENCE TOMOGRAPHY FOR BIOLOGICAL IMAGING
    4.
    发明申请
    OPTICAL COHERENCE TOMOGRAPHY FOR BIOLOGICAL IMAGING 有权
    光学相关图像生物成像

    公开(公告)号：US20100305452A1

    公开(公告)日：2010-12-02

    申请号：US12790703

    申请日：2010-05-28

    申请人： John F. Black ,  Maegan K. Spencer ,  Michael Zung ,  Charles W. McNall ,  Evangeline Lumabas ,  Michael H. Rosenthal ,  John B. Simpson

    发明人： John F. Black ,  Maegan K. Spencer ,  Michael Zung ,  Charles W. McNall ,  Evangeline Lumabas ,  Michael H. Rosenthal ,  John B. Simpson

    IPC分类号： A61B6/00

    CPC分类号： A61B5/6852 ,  A61B5/0066

    摘要： Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.

    摘要翻译： 这里描述的是用于光学相干断层扫描（OCT）的导管，其包括具有第一折射率的光纤芯和具有第二折射率的界面介质，其中第一和第二折射率不匹配，使得接收电子器件被配置为接收 从参考接口和目标反射的光辐射在总噪声范围内工作，该噪声范围在散粒噪声极限的5 dB以内。 这些OCT导管可以包括具有嵌入在界面介质中的反射涂层的硅模镜。 光纤可以固定在导管的远端处，并且可以在附接到导管主体的近端的手柄内管理，并且被配置为允许导管主体和光纤相对的两个旋转 到处理。

    Atherectomy catheter with laterally-displaceable tip
    6.
    发明授权
    Atherectomy catheter with laterally-displaceable tip 有权
    动脉粥样硬化切除导管具有横向位移尖端

    公开(公告)号：US09498600B2

    公开(公告)日：2016-11-22

    申请号：US12829277

    申请日：2010-07-01

    申请人： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    发明人： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    IPC分类号： A61M25/01 ,  A61M25/00 ,  A61B17/3207 ,  A61B17/29

    CPC分类号： A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。

    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP
    7.
    发明申请
    ATHERECTOMY CATHETER WITH LATERALLY-DISPLACEABLE TIP 有权
    ATHERECTOMY导管与侧向放置提示

    公开(公告)号：US20110004107A1

    公开(公告)日：2011-01-06

    申请号：US12829277

    申请日：2010-07-01

    申请人： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    发明人： Michael H. Rosenthal ,  Michael Zung ,  Nicholas J. Spinelli ,  Charles W. McNall ,  John B. Simpson ,  John F. Black

    IPC分类号： A61B17/22 ,  A61B6/00

    CPC分类号： A61B17/320758 ,  A61B17/32075 ,  A61B90/361 ,  A61B2017/2927 ,  A61B2017/320064 ,  A61B2017/320766 ,  A61B2017/320791 ,  A61B2090/3614 ,  A61M25/0074 ,  A61M25/0133

    摘要： Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

    摘要翻译： 这里描述了动脉粥样硬化切除术导管，系统和方法，其包括可以横向移动的远侧末端区域，使得其长轴线与主导管主体轴线的长轴平行。 将远端尖端区域横向偏离主导管主体轴线暴露环形刀片并打开用于切割组织的通道进入导管内的存储区域。 环形叶片可以内部联接到旋转叶片的驱动轴，因此暴露的叶片边缘可以具有与导管的远端区域的其余部分相同的交叉轮廓（OD）。 这里还描述了可以使用电缆驱动轴致动环形刀片的齿轮驱动的粥样斑块切除装置。 描述了切割和切割的变化，以及用于切割包括这些粥样斑块切除术导管的组织和系统的方法。