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10 条记录 (耗时 0.026 秒)

    Easily Absorbable Oral Preparations of Xanthine Derivatives
    1.
    发明申请
    Easily Absorbable Oral Preparations of Xanthine Derivatives 审中-公开
    容易吸收的黄嘌呤衍生物口服制剂

    公开(公告)号：US20100168140A1

    公开(公告)日：2010-07-01

    申请号：US12086550

    申请日：2006-12-14

    申请人： Makoto Kigoshi ,  Hideki Kato ,  Noboru Aoki

    发明人： Makoto Kigoshi ,  Hideki Kato ,  Noboru Aoki

    IPC分类号： A61K31/522

    CPC分类号： A61K9/1617 ,  A61K9/0095 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/52 ,  A61K31/522

    摘要： An object of the present invention is to provide an easily absorbable oral preparation containing a xanthine derivative or a pharmaceutically acceptable salt thereof and a fatty acid or a fatty acid derivative for the purpose of providing an easily absorbable oral preparation containing the xanthine derivative of which absorbability has been enhanced by dissolving the xanthine derivative that shows adenosine A1 receptor antagonistic activity and has diuretic activity, kidney-protecting activity, bronchodilating activity, cerebral function-improving activity, anti-dementia activity or the like in a solvent.

    摘要翻译： 本发明的目的是提供含有黄嘌呤衍生物或其药学上可接受的盐和脂肪酸或脂肪酸衍生物的容易吸收的口服制剂，其目的是提供含有可吸收性的黄嘌呤衍生物的容易吸收的口服制剂 通过在溶剂中溶解显示腺苷A1受体拮抗活性并具有利尿活性，肾保护活性，支气管扩张活性，脑功能改善活性，抗痴呆活性等的黄嘌呤衍生物而得到增强。

    Microcrystal
    2.
    发明授权
    Microcrystal 有权
    微晶

    公开(公告)号：US07541363B2

    公开(公告)日：2009-06-02

    申请号：US10554511

    申请日：2004-05-07

    申请人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

    发明人： Kazutoshi Kuroda ,  Noboru Aoki ,  Toshiro Ochiai ,  Akihiro Uchida ,  Yasuhiro Ishikawa ,  Makoto Kigoshi ,  Eiji Hayakawa ,  Kazuki Asanome

    IPC分类号： C07D473/06 ,  A61K31/522

    CPC分类号： C07D473/06

    摘要： Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 μm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

    摘要翻译： 平均粒径小于50埃的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶 妈妈 （E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮的微晶，平均粒径小于50 具有优异的溶解性，稳定性，生物利用度，药物配方中的分散性的20％以上的结晶度等。 等等。 还提供了其特征在于包含其的固体药物制剂。

    Method of Producing Coated Fine Particles
    7.
    发明申请
    Method of Producing Coated Fine Particles 审中-公开
    生产涂层微粒的方法

    公开(公告)号：US20080226704A1

    公开(公告)日：2008-09-18

    申请号：US10593723

    申请日：2005-03-23

    申请人： Makoto Kigoshi ,  Nobuhiro Yagi ,  Yasuki Kato

    发明人： Makoto Kigoshi ,  Nobuhiro Yagi ,  Yasuki Kato

    IPC分类号： A61K9/127 ,  B05D7/00 ,  B32B5/16 ,  A61K9/50

    CPC分类号： B01J13/02 ,  Y10T428/2989

    摘要： The present invention provides a method of producing coated fine particles in which core fine particles is coated with a coating layer, which comprises the steps of preparing a liquid (liquid A) containing a polar organic solvent in which core fine particles are dispersed and a component constituting a coating layer is dissolved; preparing a liquid (liquid B) which is miscible with the liquid A and does not contain a polar organic solvent or contains a polar organic solvent in a ratio lower than that in the liquid A; and letting the liquid A flow from at least one inlet of a device for producing coated fine particles equipped with an in-line mixing means having two or more inlets and one or more outlet(s) and letting the liquid B flow from at least one remaining inlet to mix the liquids thereby coating the core fine particles with the coating layer.

    摘要翻译： 本发明提供一种制备其中芯细颗粒涂覆有涂层的涂覆微粒的方法，该方法包括以下步骤：制备包含其中分散芯细颗粒的极性有机溶剂的液体（液体A）和组分 构成涂层溶解; 制备与液体A混溶并且不含极性有机溶剂或含有比液体A中的比例低的极性有机溶剂的液体（液体B）; 并且使液体A从用于生产包含具有两个或更多个入口和一个或多个出口的直列混合装置的涂覆微粒的装置的至少一个入口流出并使液体B从至少一个流出 剩余的入口混合液体，从而涂覆核心微粒与涂层。

    ORALLY DISINTEGRATING TABLET
    9.
    发明申请
    ORALLY DISINTEGRATING TABLET 有权
    ORALLY DISINCAGE TABLET

    公开(公告)号：US20130274348A1

    公开(公告)日：2013-10-17

    申请号：US13820108

    申请日：2011-08-31

    申请人： Takafumi Sato ,  Motohiro Ota ,  Makoto Kigoshi ,  Hideki Morita

    发明人： Takafumi Sato ,  Motohiro Ota ,  Makoto Kigoshi ,  Hideki Morita

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/454

    摘要： It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a process for producing the same, and the like.The present invention provides an orally disintegrating tablet comprising: at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol; a drug; a disintegrant; and at least one binder selected form methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer.

    摘要翻译： 本发明的目的是提供一种口腔崩解片，其具有理想的口腔崩解性和优异的片剂硬度，其制备方法等。 本发明提供一种口腔崩解片，其包含：至少一种选自D-甘露糖醇，乳糖，海藻糖，木糖醇，麦芽糖醇和赤藓糖醇的稀释剂; 一种药物 崩解剂 和至少一种选自甲基丙烯酸共聚物S，甲基丙烯酸共聚物L，甲基丙烯酸 - 丙烯酸乙酯共聚物，丙烯酸乙酯 -