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    NUCLEOSIDE CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION
    2.
    发明申请
    NUCLEOSIDE CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 有权
    用于治疗RNA依赖性RNA病毒感染的核苷酸环磷酰胺

    公开(公告)号：US20100022468A1

    公开(公告)日：2010-01-28

    申请号：US12519038

    申请日：2007-12-14

    申请人： Malte Meppen ,  Frank Narjes ,  Barbara Pacini ,  Cristina Gardelli ,  Philippe L. Durette

    发明人： Malte Meppen ,  Frank Narjes ,  Barbara Pacini ,  Cristina Gardelli ,  Philippe L. Durette

    IPC分类号： A61K31/7068 ,  C07H19/06 ,  A61P31/12

    CPC分类号： C07H19/06

    摘要： The present invention provides nucleoside cyclic phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as pre-cursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside cyclic phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside cyclic phosphoramidates of the present invention.

    摘要翻译： 本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂前体的结构式（I）核苷环状氨基磷酸酯。 这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。 它们作为丙型肝炎病毒（HCV）NS5B聚合酶抑制剂作为HCV复制抑制剂前体和/或用于治疗丙型肝炎感染的前体特别有用。 本发明还描述了含有这种核苷环状氨基磷酸酯的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。 还公开了本发明的核苷环状氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION
    3.
    发明申请
    NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 有权
    用于治疗RNA依赖性RNA病毒感染的核苷类ARYL磷酸酯

    公开(公告)号：US20100035835A1

    公开(公告)日：2010-02-11

    申请号：US12520738

    申请日：2007-12-28

    申请人： Frank Narjes ,  Cristina Gardelli ,  Monica Donghi ,  Barbara Attenni ,  Philippe L. Durette

    发明人： Frank Narjes ,  Cristina Gardelli ,  Monica Donghi ,  Barbara Attenni ,  Philippe L. Durette

    IPC分类号： A61K31/7068 ,  C07H19/10 ,  A61P31/00

    CPC分类号： C07H19/04 ,  C07H19/048 ,  C07H19/10 ,  C07H19/20

    摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.

    摘要翻译： 本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。 这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。 还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

    Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
    4.
    发明授权
    Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection 有权
    用于治疗RNA依赖性RNA病毒感染的核苷芳基氨基磷酸酯

    公开(公告)号：US08071568B2

    公开(公告)日：2011-12-06

    申请号：US12520738

    申请日：2007-12-28

    申请人： Frank Narjes ,  Cristina Gardelli ,  Monica Donghi ,  Barbara Attenni ,  Philippe L. Durette

    发明人： Frank Narjes ,  Cristina Gardelli ,  Monica Donghi ,  Barbara Attenni ,  Philippe L. Durette

    IPC分类号： A61K31/70 ,  C07H19/10

    CPC分类号： C07H19/04 ,  C07H19/048 ,  C07H19/10 ,  C07H19/20

    摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention. (I)

    摘要翻译： 本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。 这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。 还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。 （一世）

    Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
    10.
    发明授权
    Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use 失效
    二肽类糖类作为艾滋病免疫受损宿主中的宿主抗性增强剂和使用方法

    公开(公告)号：US4866035A

    公开(公告)日：1989-09-12

    申请号：US105056

    申请日：1987-10-05

    申请人： Philippe L. Durette

    发明人： Philippe L. Durette

    IPC分类号： A61K38/03 ,  C07K9/00

    CPC分类号： A61K31/7004 ,  A61K38/03 ,  C07K9/005

    摘要： Disclosed are specific dipeptidyl saccharide derivatives which alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, provide protection against opportunistic infection in human individuals whose resistance to infection has been specifically suppressed by an AIDS-related (HIV) virus, as well as help to suppress the AIDS-related infection itself.

    摘要翻译： 公开了单独或与抗艾滋病药物组合的特异性二肽基糖衍生物。 叠氮胸苷可以防止艾滋病相关（HIV）病毒特异性抑制感染的人群中机会性感染，有助于抑制艾滋病相关感染。