公开(公告)号：US20160363548A1

公开(公告)日：2016-12-15

申请号：US15192712

申请日：2016-06-24

申请人： Malvern Instruments Incorporated

发明人： Martin BROGA ,  Phillip PRICE ,  Stephen SMITH

IPC分类号： G01N25/48 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N25/4873 ,  B01L3/02 ,  G01K17/006 ,  G01N1/14 ,  G01N25/20 ,  G01N25/48 ,  G01N25/4813 ,  G01N25/4866 ,  G01N35/00584 ,  G01N35/0092 ,  G01N35/1002

摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

公开(公告)号：US20150276634A1

公开(公告)日：2015-10-01

申请号：US14736905

申请日：2015-06-11

申请人： Malvern Instruments Incorporated

发明人： Martin BROGA ,  Phillip PRICE ,  Stephen SMITH

IPC分类号： G01N25/48 ,  G01N35/10 ,  G01N35/00

CPC分类号： G01N25/4873 ,  B01L3/02 ,  G01K17/006 ,  G01N1/14 ,  G01N25/20 ,  G01N25/48 ,  G01N25/4813 ,  G01N25/4866 ,  G01N35/00584 ,  G01N35/0092 ,  G01N35/1002

摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

摘要翻译： 自动等温滴定微量热法（ITC）系统，其包括具有样品池和参比细胞的微量热计，样品池可通过样品细胞茎进行，参考细胞可通过参考细胞茎进入。 所述系统还包括自动移液管组件，其包括具有滴定针的注射器，所述滴定针被布置成插入到所述样品池中用于供应滴定剂，所述移液管组件包括用于驱动所述注射器中的柱塞的活化剂，支持所述移液管组件的移液管平移单元， 布置成将移液管放置在适当位置用于滴定，洗涤和灌装操作，用于滴定针的洗涤台，以及细胞制备单元，其被配置为当移液管放置在另一位置时执行替换样品池中的样品液体的操作， 滴定的位置。