公开(公告)号：US10036715B2

公开(公告)日：2018-07-31

申请号：US15192712

申请日：2016-06-24

申请人： Malvern Instruments Incorporated

发明人： Martin Broga ,  Phillip Price ,  Stephen Smith

IPC分类号： G01N25/20 ,  B01L3/02 ,  G01N35/00 ,  G01N35/10 ,  G01K17/00 ,  G01N25/48 ,  G01N1/14

摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

公开(公告)号：US09404876B2

公开(公告)日：2016-08-02

申请号：US14736905

申请日：2015-06-11

申请人： Malvern Instruments Incorporated

发明人： Martin Broga ,  Phillip Price ,  Stephen Smith

IPC分类号： G01N25/20 ,  B01L3/02 ,  G01N35/00 ,  G01N35/10 ,  G01N25/48 ,  G01K17/00 ,  G01N1/14

CPC分类号： G01N25/4873 ,  B01L3/02 ,  G01K17/006 ,  G01N1/14 ,  G01N25/20 ,  G01N25/48 ,  G01N25/4813 ,  G01N25/4866 ,  G01N35/00584 ,  G01N35/0092 ,  G01N35/1002

摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.