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    Method to Treat Flavivirus Infection with siRNA
    1.
    发明申请
    Method to Treat Flavivirus Infection with siRNA 审中-公开
    用siRNA治疗黄病毒感染的方法

    公开(公告)号：US20090047338A1

    公开(公告)日：2009-02-19

    申请号：US12089015

    申请日：2006-10-05

    申请人： Manjunath N. Swamy ,  Premlata Shankar ,  Priti Kumar ,  Sang-Kyung Lee

    发明人： Manjunath N. Swamy ,  Premlata Shankar ,  Priti Kumar ,  Sang-Kyung Lee

    IPC分类号： A61K9/127 ,  A61K31/7105 ,  A61P31/00

    CPC分类号： C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2740/15043 ,  C12N2770/24111

    摘要： The present invention is directed to methods of treating flavivirus mediated diseases using siRNAs. The invention is based upon our findings in a mouse model that siRNAs directed against sequences conserved among multiple flaviviruses prevents and treats flavivirus infections. Accordingly, the present invention provides an isolated siRNA comprising a sense RNA and an antisense RNA strand or a single strand. The sense and the antisense RNA strands, or the single RNA strand, form an RNA duplex, and wherein the RNA strand comprises a nucleotide sequence identical to a target sequence of about 15 to about 30 contiguous nucleotides in flavivirus mRNA or mutant or variant thereof.

    摘要翻译： 本发明涉及使用siRNA治疗黄病毒介导的疾病的方法。 本发明基于我们在小鼠模型中的发现，其针对多个黄病毒中保守的序列的siRNA阻止和治疗黄病毒感染。 因此，本发明提供了包含有义RNA和反义RNA链或单链的分离的siRNA。 有义和反义RNA链或单RNA链形成RNA双链体，其中RNA链包含与黄病毒mRNA或其突变体或变体中约15至约30个连续核苷酸的靶序列相同的核苷酸序列。

    Inhibition of gene expression using RNA interfering agents
    4.
    发明授权
    Inhibition of gene expression using RNA interfering agents 有权
    使用RNA干扰剂抑制基因表达

    公开(公告)号：US07696179B2

    公开(公告)日：2010-04-13

    申请号：US10533621

    申请日：2003-10-29

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Premlata Shankar

    IPC分类号： A01N63/00 ,  A61K48/00

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1617 ,  A61M1/3406 ,  A61M1/3609 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/33 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/50 ,  A61M2205/52 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  Y02A50/465

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods for the treatment and prevention of infectious diseases or disorders, e.g., HIV infection, AIDS, and AIDS-related diseases. In particular, the present invention pertains to methods of modulating cellular gene expression or protein activity, e.g., CCR5, gene expression or protein activity and/or gene expression or protein activity of a gene or sequence of an infectious agent, in order to treat or prevent infectious diseases or disorders, HIV infection, AIDS, or an AIDS-related disease or disorder. In one embodiment the combination of an RNA interfering agent targeting a cellular gene in combination with an RNA interfering agent targeting a gene or sequence of an infectious agent results in prolonged prevention of infection by an infectious agent. The present invention is based on the identification of novel RNA interference agents, e.g., siRNA molecules, which target cellular genes, e.g., chemokine receptors, e.g., the CCR5 gene, and result in inhibition of target gene expression on target gene expressing cells, thereby inhibiting entry of infectious agents, e,g., HIV infection into target cells, prevention infection, and/or suppressing replication in established infection.

    摘要翻译： 本发明至少部分地基于发现用于治疗和预防感染性疾病或病症的组合物和方法，例如HIV感染，AIDS和AIDS相关疾病。 特别地，本发明涉及调节细胞基因表达或蛋白质活性的方法，例如CCR5，基因表达或蛋白质活性和/或感染因子的基因或序列的基因表达或蛋白质活性，以便治疗或 预防传染病或疾病，艾滋病毒感染，艾滋病或艾滋病相关疾病或病症。 在一个实施方案中，靶向细胞基因的RNA干扰剂与靶向感染因子的基因或序列的RNA干扰剂的组合导致长期预防感染性感染的感染。 本发明基于鉴定靶向细胞基因（例如趋化因子受体，例如CCR5基因）的新型RNA干扰剂，例如siRNA分子，并导致靶基因表达细胞的靶基因表达的抑制，从而 抑制感染因子的侵入，例如艾滋病毒感染进入靶细胞，预防感染和/或抑制确定的感染中的复制。

    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents
    5.
    发明申请
    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents 审中-公开
    使用Rna干扰剂治疗和预防凋亡相关疾病的方法

    公开(公告)号：US20070254850A1

    公开(公告)日：2007-11-01

    申请号：US10533622

    申请日：2003-10-30

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    IPC分类号： A61K48/00 ,  C12N15/867 ,  C12N5/08

    CPC分类号： C12N15/1136 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2799/027

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods useful in the modulation, e.g., inhibition, of gene expression or protein activity. In particular, the present invention is based on novel RNA interfering agents, e.g., siRNA molecules which target apoptosis-related genes or proinflammatory cytokines, and result in reduction, e.g., prolonged reduction, of apoptosis-related gene expression or proinflammatory cytokine expression in cells. Inhibition of apoptosis-related gene expression or protein activity or proinflammatory cytokine expression or protein activity, e.g., by the siRNAs of the invention, inhibits apoptosis-mediated diseases or disorders and proinflammatory cytokine mediated diseases or disorders, including, for example, transplant rejection, hepatitis, liver injury, sepsis, and cancer.

    摘要翻译： 本发明至少部分地基于发现可用于调节，例如抑制基因表达或蛋白质活性的组合物和方法。 特别地，本发明基于新的RNA干扰剂，例如靶向凋亡相关基因或促炎细胞因子的siRNA分子，并导致细胞凋亡相关基因表达或促炎细胞因子表达的减少，例如延长的减少 。 抑制凋亡相关基因表达或蛋白质活性或促炎细胞因子表达或蛋白质活性，例如通过本发明的siRNA抑制细胞凋亡介导的疾病或病症和促炎细胞因子介导的疾病或病症，包括例如移植排斥反应， 肝炎，肝损伤，败血症和癌症。

    Inhibition of gene expression using rna interfering agents
    6.
    发明申请
    Inhibition of gene expression using rna interfering agents 有权
    使用rna干扰剂抑制基因表达

    公开(公告)号：US20060293262A1

    公开(公告)日：2006-12-28

    申请号：US10533621

    申请日：2003-10-29

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwie Song ,  Sang-Kyung Lee ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwie Song ,  Sang-Kyung Lee ,  Premlata Shankar

    IPC分类号： A61K48/00

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1617 ,  A61M1/3406 ,  A61M1/3609 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/33 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/50 ,  A61M2205/52 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  Y02A50/465

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods for the treatment and prevention of infectious diseases or disorders, e.g., HIV infection, AIDS, and AIDS-related diseases. In particular, the present invention pertains to methods of modulating cellular gene expression or protein activity, e.g., CCR5, gene expression or protein activity and/or gene expression or protein activity of a gene or sequence of an infectious agent, in order to treat or prevent infectious diseases or disorders, HIV infection, AIDS, or an AIDS-related disease or disorder. In one embodiment the combination of an RNA interfering agent targeting a cellular gene in combination with an RNA interfering agent targeting a gene or sequence of an infectious agent results in prolonged prevention of infection by an infectious agent The present invention is based on the identification of novel RNA interference agents, e.g., siRNA molecules, which target cellular genes, e.g., chemokine receptors, e.g., the CCR5 gene, and result in inhibition of target gene expression on target gene expressing cells, thereby inhibiting entry of infectious agents, e,g., HIV infection into target cells, prevention infection, and/or suppressing replication in established infection.

    摘要翻译： 本发明至少部分地基于发现用于治疗和预防感染性疾病或病症的组合物和方法，例如HIV感染，AIDS和AIDS相关疾病。 具体地，本发明涉及调节细胞基因表达或蛋白活性的方法，例如CCR5，基因表达或蛋白质活性和/或感染因子的基因或序列的基因表达或蛋白质活性，以便治疗或 预防传染病或疾病，艾滋病毒感染，艾滋病或艾滋病相关疾病或病症。 在一个实施方案中，靶向细胞基因的RNA干扰剂与靶向感染因子的基因或序列的RNA干扰剂的组合导致长期预防感染因子的感染本发明基于鉴定小鼠 RNA干扰剂，例如siRNA分子，其靶向细胞基因，例如趋化因子受体，例如CCR5基因，并导致靶基因表达细胞上的靶基因表达的抑制，从而抑制感染因子的进入，例如， ，HIV感染进入靶细胞，预防感染和/或抑制已建立的感染中的复制。

    APPARATUS AND METHOD FOR RENDERING OBJECT IN 3D GRAPHIC TERMINAL
    7.
    发明申请
    APPARATUS AND METHOD FOR RENDERING OBJECT IN 3D GRAPHIC TERMINAL 审中-公开
    3D图形终端渲染对象的设备和方法

    公开(公告)号：US20120032951A1

    公开(公告)日：2012-02-09

    申请号：US13197545

    申请日：2011-08-03

    申请人： Sang-Kyung Lee ,  Kwang-Cheol Choi ,  Hyung-Jin Bae

    发明人： Sang-Kyung Lee ,  Kwang-Cheol Choi ,  Hyung-Jin Bae

    IPC分类号： G06T15/00

    CPC分类号： H04N13/275

    摘要： A method for rendering an object in a 3D graphic terminal includes constructing camera coordinates, based on vertex information of objects existing in a 3D space, and selecting one object in a left frustum and a right frustum, based on the constructed camera coordinates, wherein the left frustum is defined centered on a left virtual camera viewpoint, and the right frustum is defined centered on a right virtual camera viewpoint. The method further includes determining a binocular disparity by projecting vertexes of the selected object in the left frustum and the right frustum, and adjusting frustum parameters of the left virtual camera and the right virtual camera when the determined binocular disparity is greater than an allowable binocular disparity.

    摘要翻译： 一种用于在3D图形终端中渲染对象的方法包括：基于所建立的相机坐标，基于存在于3D空间中的对象的顶点信息来构造相机坐标，以及选择左平截头体和右平截头体中的一个对象，其中 左平截头体被定义为以左虚拟摄像机视点为中心，并且右平截头体被定义为以右虚拟摄像机视点为中心。 该方法还包括通过将所选择的对象的顶点投影在左平截头体和右平截头体中来确定双目视差，并且当确定的双目视差大于允许的双目视差时调整左虚拟照相机和右虚拟照相机的平截头体参数 。

    COMPOSITION FOR TREATING INFLAMMATORY, ALLERGIC OR ASTHMA DISEASES, CONTAINING PAPRIKA EXTRACTS
    10.
    发明申请
    COMPOSITION FOR TREATING INFLAMMATORY, ALLERGIC OR ASTHMA DISEASES, CONTAINING PAPRIKA EXTRACTS 审中-公开
    用于治疗含有PAPRIKA提取物的炎症，过敏或哮喘病的组合物

    公开(公告)号：US20130071499A1

    公开(公告)日：2013-03-21

    申请号：US13636451

    申请日：2011-03-22

    申请人： Sang-Kyung Lee ,  Young-Jin You ,  Hyo-Sung Choi ,  Min-Young Park

    发明人： Sang-Kyung Lee ,  Young-Jin You ,  Hyo-Sung Choi ,  Min-Young Park

    IPC分类号： A61K36/81

    CPC分类号： A61K36/81

    摘要： The present invention relates to a composition containing a paprika extract as an active ingredient, and more particularly to a pharmaceutical composition or health functional food for preventing or treating inflammatory, allergic or asthma disease, which contains a paprika extract. Particularly, paprika is a natural food which is readily available to anyone, and thus does not cause adverse effects even when it is taken for a long period of time.

    摘要翻译： 本发明涉及含有辣椒粉提取物作为活性成分的组合物，更具体地涉及含有辣椒粉提取物的用于预防或治疗炎性，过敏性或哮喘病的药物组合物或保健功能性食品。 特别地，辣椒粉是天然食物，任何人都可以使用，因此即使长时间服用也不会产生不利影响。