公开(公告)号：US09662461B2

公开(公告)日：2017-05-30

申请号：US15144651

申请日：2016-05-02

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00 ,  A61M11/06

CPC classification number: A61M15/0091 ,  A61M11/06 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.

公开(公告)号：US20160243322A1

公开(公告)日：2016-08-25

申请号：US15144651

申请日：2016-05-02

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00

CPC classification number: A61M15/0091 ,  A61M11/06 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.

Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括用于治疗疾病和病症的胰岛素和胰高血糖素样肽1 ，例如内分泌疾病如糖尿病和/或肥胖症。