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公开(公告)号：US20190262557A1
公开(公告)日：2019-08-29
申请号：US16410191
申请日：2019-05-13
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
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公开(公告)号：US10342938B2
公开(公告)日：2019-07-09
申请号：US15182503
申请日：2016-06-14
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
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公开(公告)号：US20150283213A1
公开(公告)日：2015-10-08
申请号：US14719920
申请日：2015-05-22
申请人： MannKind Corporation
CPC分类号： A61K38/26 , A61K9/0075 , A61K31/4965 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
摘要翻译： 提供了一种用于治疗受试者的高血糖症和/或糖尿病的方法。 特别地，该方法旨在治疗具有大于约8mM的空腹血糖浓度的2型糖尿病患者，其中通过肺吸入向患者施用包含GLP-1分子和二酮哌嗪的制剂， 干粉吸入系统。
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公开(公告)号：US20150080298A1
公开(公告)日：2015-03-19
申请号：US14548074
申请日：2014-11-19
申请人： MannKind Corporation
IPC分类号： A61K38/26 , A61K45/06 , A61K9/00 , A61K31/495
CPC分类号： A61K38/26 , A61K9/0075 , A61K9/1641 , A61K9/167 , A61K9/1676 , A61K31/495 , A61K38/22 , A61K38/28 , A61K45/06 , C07K14/57545 , A61K2300/00
摘要： A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
摘要翻译： 提供了一种用于治疗受试者的高血糖症和/或糖尿病的方法。 特别地，该方法旨在治疗具有大于约8mM的空腹血糖浓度的2型糖尿病患者，其中通过肺吸入向患者施用包含GLP-1分子和二酮哌嗪的制剂， 干粉吸入系统。
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公开(公告)号：US20130291867A1
公开(公告)日：2013-11-07
申请号：US13933845
申请日：2013-07-02
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61K9/0075 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6081
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation.
摘要翻译： 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备有药物递送制剂。
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公开(公告)号：US20200147180A1
公开(公告)日：2020-05-14
申请号：US16721357
申请日：2019-12-19
申请人： MannKind Corporation
IPC分类号： A61K38/26 , A61K45/06 , A61K9/00 , A61K31/4965 , A61K47/26
摘要： A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
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公开(公告)号：US09662461B2
公开(公告)日：2017-05-30
申请号：US15144651
申请日：2016-05-02
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl Sahi , Christine Billings , Mark T. Marino
CPC分类号： A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
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公开(公告)号：US20160243322A1
公开(公告)日：2016-08-25
申请号：US15144651
申请日：2016-05-02
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl Sahi , Christine Billings , Mark T. Marino
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
摘要翻译： 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括用于治疗疾病和病症的胰岛素和胰高血糖素样肽1 ，例如内分泌疾病如糖尿病和/或肥胖症。
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公开(公告)号：US09393372B2
公开(公告)日：2016-07-19
申请号：US13933845
申请日：2013-07-02
申请人： MannKind Corporation
发明人： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
CPC分类号： A61M15/0091 , A61K9/0075 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6081
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation.
摘要翻译： 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备有药物递送制剂。
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公开(公告)号：US11304992B2
公开(公告)日：2022-04-19
申请号：US16721357
申请日：2019-12-19
申请人： MannKind Corporation
IPC分类号： A61K31/706 , A61K9/00 , A61K38/26 , A61K45/06 , A61K31/4965 , A61K47/26
摘要： A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
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