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1.
公开(公告)号:US20050085457A1
公开(公告)日:2005-04-21
申请号:US10494196
申请日:2002-11-01
申请人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
发明人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
IPC分类号: C07D215/42 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P1/00 , A61P1/14 , A61P3/04 , A61P5/00 , A61P9/00 , A61P15/00 , A61P15/10 , A61P21/00 , A61P21/02 , A61P25/14 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D207/14 , C07D215/233 , C07D215/48 , C07D241/04 , C07D243/08 , C07D265/30 , C07D311/24 , C07D311/66 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D521/00 , A61K31/55 , A61K31/4709 , C07D43/02
CPC分类号: C07D231/12 , C07D215/48 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/66 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/12
摘要: Provided herein is a compound having the formula (I) (R2 is typically a tertiary nitrogen atom, being either alkyl-substituted or member of q heterocyclic ring; R7 is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ring) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物(R 2)通常为叔氮原子,为烷基取代或q杂环的成员; R 7为 通常为单环或双环芳族环或杂环),其中所述化合物可用于治疗精神病学障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号:US20060019947A1
公开(公告)日:2006-01-26
申请号:US11229170
申请日:2005-09-16
申请人: Marc Chapdelaine , Timothy Davenport , Markus Haeberlein , Carey Horchler , John McCauley , Edward Pierson , Daniel Sohn
发明人: Marc Chapdelaine , Timothy Davenport , Markus Haeberlein , Carey Horchler , John McCauley , Edward Pierson , Daniel Sohn
IPC分类号: A61K31/541 , A61K31/496 , A61K31/452 , A61K31/4178 , A61K31/353 , C07D417/02 , C07D405/02
CPC分类号: C07D231/12 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B in antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.
摘要翻译: 本文提供了式(I)的化合物,其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 化合物是拮抗剂中的5HT 1B。 本文还提供了制备式(I)化合物和中间体化合物的方法。
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公开(公告)号:US20050182050A1
公开(公告)日:2005-08-18
申请号:US11108587
申请日:2005-04-18
申请人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
发明人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
IPC分类号: C07D215/48 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P5/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D215/50 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00 , C07D413/14 , C07D417/14 , C07D45/14
CPC分类号: C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物:其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号:US20080076759A1
公开(公告)日:2008-03-27
申请号:US11864102
申请日:2007-09-28
申请人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
发明人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
IPC分类号: A61K31/551 , A61K31/495 , A61K31/497 , A61P1/00 , A61P21/00 , A61P5/00 , A61P9/00 , A61P25/06 , A61P15/00 , A61K31/5377 , A61K31/541
CPC分类号: C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物:其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5个HT 1B和5个HT 1D 1拮抗剂。
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5.
公开(公告)号:US20050096312A1
公开(公告)日:2005-05-05
申请号:US10494197
申请日:2002-11-01
申请人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
发明人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
IPC分类号: C07D215/48 , A61K31/496 , A61K31/5377 , A61K31/551 , A61P1/00 , A61P3/04 , A61P5/00 , A61P9/00 , A61P15/00 , A61P15/10 , A61P21/02 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D207/14 , C07D215/22 , C07D215/233 , C07D215/42 , C07D241/04 , C07D243/08 , C07D265/30 , C07D311/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/12 , A61K31/4709 , C07D43/02
CPC分类号: C07D215/233 , C07D215/42 , C07D311/24 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , Y02E60/324
摘要: Provided herein is a compound having the formula (I), (R2 is typically a tertiary nitrogen atom, being either alkyl-substituted or member of a heterocyclic ring; R7 is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ring) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供的是具有式(I)的化合物,(R 2)通常是叔氮原子,被烷基取代或是杂环的成员; R 7, 通常是单环或双环芳族环或杂环),其中所述化合物可用于治疗精神病学障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号:US20060178372A1
公开(公告)日:2006-08-10
申请号:US11397081
申请日:2006-04-04
申请人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
发明人: Markus Haeberlein , Daniel Sohn , Marc Chapdelaine , Timothy Davenport , Carey Horchler , Edward Pierson , John McCauley
IPC分类号: A61K31/496 , A61K31/4709 , C07D403/02 , C07D215/36
CPC分类号: C07D215/233 , C07D215/42 , C07D311/24 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , Y02E60/324
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物:其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号:US07026314B2
公开(公告)日:2006-04-11
申请号:US10466449
申请日:2002-01-15
申请人: Marc Chapdelaine , Timothy Davenport , Markus Haeberlein , Carey Horchler , John McCauley , Edward Pierson , Daniel Sohn
发明人: Marc Chapdelaine , Timothy Davenport , Markus Haeberlein , Carey Horchler , John McCauley , Edward Pierson , Daniel Sohn
IPC分类号: C07D403/04 , C07D403/14 , A61K31/496 , A61P25/24 , A61P3/04
CPC分类号: C07D231/12 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.
摘要翻译: 本文提供了式(I)的化合物,其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1 B 1拮抗剂。 本文还提供了制备式(I)化合物和中间体化合物的方法。
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公开(公告)号:US20050009818A1
公开(公告)日:2005-01-13
申请号:US10889350
申请日:2004-07-12
申请人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
发明人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John McCauley
IPC分类号: C07D215/48 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P5/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D215/50 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00 , C07D417/14 , C07D413/14 , C07
CPC分类号: C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物:其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 这些化合物是5HT1B和5HT1D拮抗剂。
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公开(公告)号:US06812225B2
公开(公告)日:2004-11-02
申请号:US10051776
申请日:2002-01-16
申请人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
发明人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
IPC分类号: A61K3137
CPC分类号: C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
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公开(公告)号:US07285662B2
公开(公告)日:2007-10-23
申请号:US11108587
申请日:2005-04-18
申请人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
发明人: Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
IPC分类号: C07D413/14 , C07D407/04
CPC分类号: C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要: Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供具有式(I)的化合物:其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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