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公开(公告)号：US6027725A
公开(公告)日：2000-02-22
申请号：US166093
申请日：1998-10-05
申请人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
发明人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
IPC分类号： A61P37/04 , C07K1/22 , C07K16/30 , C07K16/44 , C07K16/46 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： C07K1/22 , C07K16/30 , C07K16/44 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
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公开(公告)号：US6025165A
公开(公告)日：2000-02-15
申请号：US166750
申请日：1998-10-05
申请人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
发明人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
IPC分类号： A61P37/04 , C07K1/22 , C07K16/30 , C07K16/44 , C07K16/46 , C12P21/08 , A61K39/395 , C07H21/04 , C07K16/00
CPC分类号： C07K1/22 , C07K16/30 , C07K16/44 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
摘要翻译： 描述和要求保护编码的遗传结构的组合物和用于产生多价抗原结合蛋白的方法。 所述方法包括纯化含有单一和多价形式的单一多肽链分子的组合物，以及从纯化单体产生多价蛋白质。 多价蛋白质的产生可以通过单体蛋白质的浓度依赖性缔合，或通过重新排列涉及解离的区域，然后重新结合不同的区域来进行。 在本发明中制备了包含同型和异二价蛋白质的二价蛋白质。 公开了编码二价单链抗原结合蛋白的遗传序列。 用途包括适用于单克隆和多克隆抗体及其片段的所有应用，包括用作双特异性抗原结合分子。
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公开(公告)号：US06515110B1
公开(公告)日：2003-02-04
申请号：US09443213
申请日：1999-11-19
申请人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
发明人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
IPC分类号： C12P2108
CPC分类号： C07K1/22 , A61K2039/505 , C07K16/30 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
摘要翻译： 描述和要求保护编码的遗传结构的组合物和用于产生多价抗原结合蛋白的方法。 所述方法包括纯化含有单一和多价形式的单一多肽链分子的组合物，以及从纯化单体产生多价蛋白质。 多价蛋白质的产生可以通过单体蛋白质的浓度依赖性缔合，或者通过重新排列涉及解离的区域，然后重新结合不同的区域来进行。 在本发明中制备了包含同型和异二价蛋白质的二价蛋白质。 公开了编码二价单链抗原结合蛋白的遗传序列。 用途包括适用于单克隆和多克隆抗体及其片段的所有应用，包括用作双特异性抗原结合分子。
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公开(公告)号：US6121424A
公开(公告)日：2000-09-19
申请号：US166094
申请日：1998-10-05
申请人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
发明人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
IPC分类号： A61P37/04 , C07K1/22 , C07K16/30 , C07K16/44 , C07K16/46 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： C07K1/22 , C07K16/30 , C07K16/44 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
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公开(公告)号：US5869620A
公开(公告)日：1999-02-09
申请号：US392338
申请日：1995-02-22
申请人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
发明人： Marc D. Whitlow , James F. Wood , Karl D. Hardman , Robert E. Bird , David Filpula , Michele Rollence
CPC分类号： C07K16/30 , C07K16/44 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/02
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
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公开(公告)号：US06103889A
公开(公告)日：2000-08-15
申请号：US172019
申请日：1998-10-14
IPC分类号： A61P37/04 , C07K1/22 , C07K16/30 , C07K16/44 , C07K16/46 , C12P21/08 , C07H21/02 , C07H21/04
CPC分类号： C07K1/22 , C07K16/30 , C07K16/44 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
摘要翻译： 描述和要求保护编码的遗传结构的组合物和用于产生多价抗原结合蛋白的方法。 所述方法包括纯化含有单一和多价形式的单一多肽链分子的组合物，以及从纯化单体制备多价蛋白质。 多价蛋白质的产生可以通过单体蛋白质的浓度依赖性缔合，或者通过重新排列涉及解离的区域，然后重新结合不同的区域来进行。 在本发明中制备了包含同型和异二价蛋白质的二价蛋白质。 公开了编码二价单链抗原结合蛋白的遗传序列。 用途包括适用于单克隆和多克隆抗体及其片段的所有应用，包括用作双特异性抗原结合分子。
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7.发明授权Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof 失效抗erbB-2抗体，其组合，及其治疗和诊断用途
公开(公告)号：US5587458A
公开(公告)日：1996-12-24
申请号：US61092
申请日：1993-05-14
摘要： The present invention relates to novel antibodies, in particular monoclonal and single chain antibodies derived therefrom which specifically bind to erbB-2, as well as diagnostic and therapeutic uses thereof. The present invention also relates to a combination of at least two erbB-2 specific antibodies which are capable of preventing and treating human malignancies wherein the malignant cells overexpress gp185.sup.erbB-2. The monoclonal antibodies of the combination preferably recognize different epitopes of the gp185 expression product of erbB-2, therefore, the antibodies do not cross react with each other. Preferably, the combination will provide for synergistic decrease in the expression of the erbB-2 gene product.
摘要翻译： 本发明涉及特异性结合erbB-2的新型抗体，特别是衍生自其的单克隆抗体和单链抗体，以及其诊断和治疗用途。 本发明还涉及能够预防和治疗恶性细胞过表达gp185erbB-2的人类恶性肿瘤的至少两种erbB-2特异性抗体的组合。 组合的单克隆抗体优选识别erbB-2的gp185表达产物的不同表位，因此，抗体彼此不交叉反应。 优选地，组合将提供erbB-2基因产物的表达的协同降低。
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公开(公告)号：US5455030A
公开(公告)日：1995-10-03
申请号：US40440
申请日：1993-04-01
申请人： Robert C. Ladner , Robert E. Bird , Karl Hardman
发明人： Robert C. Ladner , Robert E. Bird , Karl Hardman
CPC分类号： C07K16/468 , C07K1/1075 , C07K16/00 , C07K16/30 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
摘要翻译： 本发明涉及单个多肽链结合分子，其具有与抗体的轻链和重链聚集体可变区的结合特异性和亲和力，编码的遗传序列的结合特异性和亲和力以及重组DNA生产方法 这样的分子和用途。
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公开(公告)号：US5518889A
公开(公告)日：1996-05-21
申请号：US468988
申请日：1995-06-06
申请人： Robert C. Ladner , Robert E. Bird , Karl Hardman
发明人： Robert C. Ladner , Robert E. Bird , Karl Hardman
IPC分类号： A61K38/00 , C07K1/107 , C07K16/00 , C07K16/30 , C07K16/46 , C12P21/08 , G01N33/53 , G01N33/534 , G01N33/535 , G01N33/543
CPC分类号： C07K16/468 , C07K1/1075 , C07K16/00 , C07K16/30 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
摘要翻译： 本发明涉及单个多肽链结合分子，其具有与抗体的轻链和重链聚集体可变区的结合特异性和亲和力，编码的遗传序列的结合特异性和亲和力以及重组DNA生产方法 这样的分子和用途。
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公开(公告)号：US4946778A
公开(公告)日：1990-08-07
申请号：US299617
申请日：1989-01-19
申请人： Robert C. Ladner , Robert E. Bird , Karl Hardman
发明人： Robert C. Ladner , Robert E. Bird , Karl Hardman
CPC分类号： C07K16/468 , C07K16/00 , C07K16/30 , C07K2319/00 , C07K2319/036 , Y10S530/861 , Y10S530/866 , Y10S530/867
摘要： The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
摘要翻译： 本发明涉及单个多肽链结合分子，其具有与抗体的轻链和重链聚集体可变区的结合特异性和亲和力，编码的遗传序列的结合特异性和亲和力以及重组DNA生产方法 这样的分子和用途。
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