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    Methods for identifying compounds that regulate β-Arrestin signaling complexes
    3.
    发明授权
    Methods for identifying compounds that regulate β-Arrestin signaling complexes 有权
    鉴定化合物的方法 - 调节和抑制--Arrestin信号复合物

    公开(公告)号：US07763437B1

    公开(公告)日：2010-07-27

    申请号：US11482277

    申请日：2006-07-07

    申请人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sébastien Marion

    发明人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sébastien Marion

    IPC分类号： G01N33/53

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.

    摘要翻译： 一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触 形成 然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。 还描述了用于实施该方法的组合物和试剂盒。

    Methods for identifying compounds that regulate beta-arrestin signaling complexes
    4.
    发明授权
    Methods for identifying compounds that regulate beta-arrestin signaling complexes 有权
    鉴定调节β-抑制蛋白信号复合物的化合物的方法

    公开(公告)号：US07999075B2

    公开(公告)日：2011-08-16

    申请号：US12816764

    申请日：2010-06-16

    申请人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sébastien Marion

    发明人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sébastien Marion

    IPC分类号： C12N11/18 ,  C12N9/12 ,  C12N9/14 ,  C07K14/47

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.

    摘要翻译： 一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触 形成 然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。 还描述了用于实施该方法的组合物和试剂盒。

    METHODS FOR IDENTIFYING COMPOUNDS THAT REGULATE BETA-ARRESTIN SIGNALING COMPLEXES
    5.
    发明申请
    METHODS FOR IDENTIFYING COMPOUNDS THAT REGULATE BETA-ARRESTIN SIGNALING COMPLEXES 有权
    用于鉴定化合物的方法，所述化合物调节β-阿霉素信号复合物

    公开(公告)号：US20100255498A1

    公开(公告)日：2010-10-07

    申请号：US12816764

    申请日：2010-06-16

    申请人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sebastien Marion

    发明人： Marc G. Caron ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatiana D. Sotnikova ,  Sebastien Marion

    IPC分类号： G01N33/53 ,  C07K19/00 ,  C12N9/12 ,  C12N9/16

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.

    摘要翻译： 一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触 形成 然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。 还描述了用于实施该方法的组合物和试剂盒。

    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    6.
    发明授权
    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
    在脑特异性色氨酸羟化酶中携带功能单核苷酸多态性的转基因小鼠

    公开(公告)号：US08124831B2

    公开(公告)日：2012-02-28

    申请号：US11825202

    申请日：2007-07-05

    申请人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    发明人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    IPC分类号： A01K67/027 ,  G01N33/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30

    摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells.

    摘要翻译： 描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。 在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。 还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。 提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性 神经传递异常调节障碍。 还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。