公开(公告)号：US5565331A

公开(公告)日：1996-10-15

申请号：US152019

申请日：1993-11-12

申请人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

发明人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

IPC分类号： A01K67/027 ,  A61K38/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/48 ,  C07K14/705 ,  C07K14/71 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/68 ,  C12N15/00

CPC分类号： G01N33/6896 ,  C07K14/4705 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  A61K38/00 ,  G01N2500/04

摘要： A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury. The disclosed compositions also find use variously in screening chemical libraries for regulators of axon outgrowth and orientation, in genetic mapping, as probes for related genes, as diagnostic reagents for genetic neurological disease and in the production of specific cellular and animal systems for the development of neurological disease therapy.

摘要翻译： 公开了一类促进和定向蛋白质的神经轴突生长，编码这种蛋白质的核酸和选择性结合这些蛋白质的受体。 所公开的神经轴突生长促进和定向蛋白质包括层粘连蛋白相关的p75 / p78家族; 促进轴突生长和/或取向的脊椎动物蛋白家族，以及p75 / p78家族特异性受体，包括在脊髓神经轴突，特别是生长锥上发现的受体。 还公开了包括衍生自所公开的神经轴突生长促进能够产生轴突向外生长，取向和再生的蛋白质的肽的试剂。 这些试剂提供了可用于治疗神经疾病和损伤的神经细胞生长的小分子量调节剂。 所公开的组合物还可用于筛选用于轴突生长和取向的调节剂的化学文库，遗传作图中作为相关基因的探针，作为遗传神经疾病的诊断试剂，以及用于开发特异性细胞和动物系统的生产 神经疾病治疗。