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    Nucleic acids encoding neural axon outgrowth modulators
    1.
    发明授权
    Nucleic acids encoding neural axon outgrowth modulators 失效
    核酸编码神经轴突生长调节剂

    公开(公告)号：US5565331A

    公开(公告)日：1996-10-15

    申请号：US152019

    申请日：1993-11-12

    申请人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    发明人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/48 ,  C07K14/705 ,  C07K14/71 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/68 ,  C12N15/00

    CPC分类号： G01N33/6896 ,  C07K14/4705 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  A61K38/00 ,  G01N2500/04

    摘要： A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury. The disclosed compositions also find use variously in screening chemical libraries for regulators of axon outgrowth and orientation, in genetic mapping, as probes for related genes, as diagnostic reagents for genetic neurological disease and in the production of specific cellular and animal systems for the development of neurological disease therapy.

    摘要翻译： 公开了一类促进和定向蛋白质的神经轴突生长，编码这种蛋白质的核酸和选择性结合这些蛋白质的受体。 所公开的神经轴突生长促进和定向蛋白质包括层粘连蛋白相关的p75 / p78家族; 促进轴突生长和/或取向的脊椎动物蛋白家族，以及p75 / p78家族特异性受体，包括在脊髓神经轴突，特别是生长锥上发现的受体。 还公开了包括衍生自所公开的神经轴突生长促进能够产生轴突向外生长，取向和再生的蛋白质的肽的试剂。 这些试剂提供了可用于治疗神经疾病和损伤的神经细胞生长的小分子量调节剂。 所公开的组合物还可用于筛选用于轴突生长和取向的调节剂的化学文库，遗传作图中作为相关基因的探针，作为遗传神经疾病的诊断试剂，以及用于开发特异性细胞和动物系统的生产 神经疾病治疗。

    Methods for inducing differentiation of embryonic stem cells and uses thereof
    10.
    发明授权
    Methods for inducing differentiation of embryonic stem cells and uses thereof 有权
    诱导胚胎干细胞分化的方法及其用途

    公开(公告)号：US07390659B2

    公开(公告)日：2008-06-24

    申请号：US10196882

    申请日：2002-07-16

    申请人： Thomas Jessell ,  Hynek Wichterle ,  Ivo Lieberam

    发明人： Thomas Jessell ,  Hynek Wichterle ,  Ivo Lieberam

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0619 ,  A61K35/12 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  Y02A50/465

    摘要： The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

    摘要翻译： 本发明提供了诱导胚胎干细胞分化为分化神经细胞的方法。 本发明还提供了用于产生分化的神经细胞的方法和包含分化的神经细胞的细胞群。 另外，本发明提供了一种用于在受试者中重新填充脊髓的方法，以及用于治疗需要治疗的受试者中的神经组织变性的方法。 本发明还提供神经祖细胞，分化神经细胞及其用途。 还提供了含有分化的神经细胞的转基因非人动物。 本发明还涉及分离分化的神经细胞群体的方法。 最后，本发明提供一种用于鉴定用于治疗与神经元变性相关的病症的药剂的方法。