摘要:
The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutical compositions thereof, and to the therapeutic use thereof.
摘要:
A capping machine (1) of carousel design comprises a centre shaft (2) turning on a fixed base frame (3) about a vertical axis of rotation (Y), a set of capping units (4) encircling and revolving as one with the shaft (2) about the axis of rotation (Y), and a cylindrical cam (5) interposed between the shaft (2) and the capping units (4), by which the single units (4) are caused to move toward and away from the fixed base frame (3). During operation, the cam (5) is held in at least one predetermined fixed position relative to the base frame (3) by a single supporting element (6) anchored to the base frame (3), concealed internally of the rotating shaft (2) and connected to the cam (5), which represents a departure from the conventional method of supporting the cam on two or more columns located externally of the carousel structure and exposed to view.
摘要:
A rotary conveyor (1) utilized in equipment (1a) for filling containers (2) with liquid or powder products includes a supporting shaft (8) aligned on a longitudinal axis (X) and coupled to relative drive components (10) associated with the shaft (8), by which the shaft is set in rotation about the axis (X). A support element (11) is keyed to the shaft (8), presenting a peripheral rim (12) with a plurality of slots (13) each designed to accommodate a container (2) transferred from a transport and/or processing device (3) forming part of the equipment (1a). The slots (13) incorporate restraining components (14) having grippers (15) movable between a position of engagement, in which the containers (2) are locked to the support element (11), and a position of disengagement in which no restraining force is applied to the containers (2).
摘要:
Containers for packaging liquid or powder products are directed onto a carousel (1) presenting a support element (9) equipped with a number of peripheral stations (10), each accommodating a relative container (2), and set in rotation about a vertical axis (X) by a drive system (6) housed internally of floor-standing frame (5) on which the carousel (1) is mounted. The support element (9) presents substantially disc-like appearance and is hollow, composed of a top panel (11) and a bottom panel (12) distanced one from another in such a way as to create an annular chamber (13) between the two panels.
摘要:
A rotary conveyor (1) utilized in equipment (Ia) for filling containers (2) with liquid or powder products comprises a supporting shaft (8) aligned on a longitudinal axis (X) and coupled to relative drive components (10) associated with the shaft (8), by which the shaft is set in rotation about the axis (X), also a support element (11) keyed to the shaft (8), presenting a peripheral rim (12) with a plurality of slots (13) each designed to accommodate a container (2) transferred from a transport and/or processing device (3) forming part of the equipment (1a). The slots (13) incorporate restraining components (14) consisting in grippers (15) capable of movement between a position of engagement, in which the containers (2) are locked to the support element (11), and a position of disengagement in which no restraining force is applied to the containers (2).
摘要:
The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要:
The present invention relates to compounds of formula (I): in which R1 represents a hydrogen or halogen atom, or a group CF3; R2 and R3 represent, independently, a hydrogen atom or a methyl group; n and n′ each represent, independently, 0 or 1; * represents the positions of attachment; A represents N or CH; X represents a sulfur or oxygen atom; R4 and R5 represent, independently, a hydrogen atom or a (C1-C6) alkyl group; and also their salts or solvates, to a method for the preparation thereof and to the pharmaceutical compositions containing them.
摘要:
The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要:
The invention relates to compounds of the formula in which: Y is --CH-- or --N--; R.sub.1 is hydrogen, a halogen or a CF.sub.3, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.2 is a methyl or ethyl group; R.sub.3 and R.sub.4 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl; and X is:(a) a (C.sub.1 -C.sub.6)alkyl, a (C.sub.1 -C.sub.6)alkoxy, a (C.sub.3 -C.sub.7)carboxyalkyl, a (C.sub.1 -C.sub.4)alkoxy-carbonyl(C.sub.1 -C.sub.6)alkyl, a (C.sub.3 -C.sub.7)carboxyalkoxy or a (C.sub.1 -C.sub.4)alkoxycarbonyl-(C.sub.1 -C.sub.6)alkoxy;(b) a radical selected from (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkoxy, (C.sub.3 -C.sub.7)-cycloalkylmethyl, (C.sub.3 -C.sub.7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, amino or mono- or di-(C.sub.1 -C.sub.4)-alkylamino; or(c) a group selected from a phenyl, phenoxy, phenylamino, N-(C.sub.1 -C.sub.3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF.sub.3, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, cyano, amino, mono- or di-(C.sub.1 -C.sub.4)alkyl-amino, (C.sub.1 -C.sub.4)acylamino, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C.sub.1 -C.sub.4)alkylaminocarbonyl, amino(C.sub.1 -C.sub.4)alkyl, hydroxy(C.sub.1 -C.sub.4)alkyl or halogeno(C.sub.1 -C.sub.4)alkyl;to a method of preparing them and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.
摘要:
The present invention relates to new 1-heteroarylazetidines and new 1-heteroarylpyrrolidines endowed with 5-HT.sub.3 agonist activity of formula (IV): ##STR1## The substituents A, R', R.sub.1 and P, and the variables n and m, are as herein described.