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1.发明申请Apparatus and Method for Counting and Identifying Particles of Interest in a Fluid 有权用于计数和识别流体中感兴趣的颗粒的装置和方法公开(公告)号：US20110050200A1
公开(公告)日：2011-03-03
申请号：US12866646
申请日：2009-02-06
申请人： Marco Tartagni , Michele Rossi , Nicolò Manaresi
发明人： Marco Tartagni , Michele Rossi , Nicolò Manaresi
IPC分类号： G01N15/12
CPC分类号： G01N15/12 , G01N15/1056 , G01N15/1218 , G01N15/1245 , G01N2015/0038 , G01N2015/1037 , G01N2015/1062 , G01N2015/1254
摘要： The invention relates to an apparatus for counting particles in a fluid comprising a substrate having a first surface; a lid having a second surface facing the first; at least one spacer element interposed between the substrate and the lid so as to maintain the first and second surface spaced from one another; a partition with a plurality of through-openings having nanometric size, the partition being interposed between the spacer element and the lid so as to define at least one first chamber between the partition and the lid and at least one second chamber between the partition and the substrate, the chambers being fluidically connected with one another through at least one of the openings. According to the invention, the substrate has at least one first electrode on the first surface and the lid has a second electrode, each first electrode being configured so as to detect an electric signal associated to the passage of one of said particles through one of the through-openings of the partition. The invention further relates to a corresponding method for counting particles in a fluid.
摘要翻译： 本发明涉及一种用于计数流体中颗粒的装置，包括具有第一表面的基底; 具有面向第一表面的第二表面的盖; 插入在所述基板和所述盖之间的至少一个间隔元件，以便保持所述第一和第二表面彼此间隔开; 具有多个具有纳米尺寸的通孔的分隔件，所述分隔件插入在所述间隔元件和所述盖之间，以便限定所述隔板和所述盖之间的至少一个第一室以及所述分隔件与所述盖之间的至少一个第二室 衬底，腔室通过至少一个开口彼此流体连接。 根据本发明，衬底在第一表面上具有至少一个第一电极，盖具有第二电极，每个第一电极被配置为检测与所述颗粒中的一个通过之一相关的电信号 分区的通孔。 本发明还涉及用于计算流体中颗粒的相应方法。
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2.发明授权Apparatus and method for counting and identifying particles of interest in a fluid 有权用于计数和识别流体中感兴趣的颗粒的装置和方法公开(公告)号：US08686709B2
公开(公告)日：2014-04-01
申请号：US12866646
申请日：2009-02-06
申请人： Marco Tartagni , Michele Rossi , Nicolò Manaresi
发明人： Marco Tartagni , Michele Rossi , Nicolò Manaresi
IPC分类号： G01N27/00
CPC分类号： G01N15/12 , G01N15/1056 , G01N15/1218 , G01N15/1245 , G01N2015/0038 , G01N2015/1037 , G01N2015/1062 , G01N2015/1254
摘要： Apparatus and associate method including a substrate having a first surface; a lid having a second surface; at least one spacer element interposed between the substrate and the lid so as to maintain the first and second surface spaced apart; a partition with a plurality of nanometric size through-openings interposed between the spacer element and the lid defining a first chamber a second chamber fluidically connected together through at least one of the openings; the substrate has at least one first electrode on the first surface and the lid has a second electrode, the first electrode being configured to detect an electric signal associated to the passage of one of said particles through one of the through-openings.
摘要翻译： 包括具有第一表面的基底的装置和相关方法; 具有第二表面的盖; 插入在所述基板和所述盖之间的至少一个间隔元件，以便保持所述第一和第二表面间隔开; 具有插入在所述间隔元件和所述盖之间的多个纳米尺寸的通孔的分隔件限定第一室，所述第一室通过至少一个所述开口流体连接在一起; 所述基板在所述第一表面上具有至少一个第一电极，并且所述盖具有第二电极，所述第一电极被配置为检测与通过所述通孔之一通过所述颗粒中的一个的电信号。
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3.发明授权Method and apparatus for high-throughput biological-activity screening of cells and/or compounds 有权用于细胞和/或化合物的高通量生物活性筛选的方法和装置公开(公告)号：US07699969B2
公开(公告)日：2010-04-20
申请号：US10476467
申请日：2002-05-02
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/54366 , G01N33/561
摘要： First entities consisting in cells or microorganisms (BIO) and second entities consisting in compounds or compound units, carried typically by microbeads (BEAD), are trapped selectively within closed movable potential cages (S1) by means of dielectrophoretic force generated by mutually opposed electrodes (M1, M2). The cages are set in relative motion so as to bring about the interaction of selected first and second entities, causing the cages containing them to fuse, whereupon results are obtained preferably by reinstating the original cages and/or observing previously empty adjacent cages. The procedure takes place in a device (DE) with two separate chambers (F, FL) connected one to the other by way of a narrow passage (D) and finished with respective selectively controllable inlets and outlets (I1, I2; O1, O2) through which a liquid or semi-liquid buffer (L) can be pumped in or out.
摘要翻译： 由细胞或微生物（BIO）组成的第一实体和通常由微珠（BEAD）携带的化合物或复合单元中的第二实体，通过由相互相对的电极产生的介电电泳力选择性地封闭在封闭的可移动电位笼（S1）内 M1，M2）。 笼子被设置为相对运动以便引起所选择的第一和第二实体的相互作用，导致包含它们的笼子融合，从而优选地通过恢复原始笼子和/或观察先前空的相邻笼子获得结果。 该程序在具有通过狭窄通道（D）彼此连接的两个分开的室（F，FL）的装置（DE）中进行，并且用相应的可选择性地控制的入口和出口（I1，I2; O1，O2 ）可以将液体或半液体缓冲液（L）泵入或流出。
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4.发明授权Textile-like capacitive pressure sensor and method of mapping the pressure exerted at points of a surface of a flexible and pliable object, particularly of a sail 有权类似纺织品的电容式压力传感器和映射在柔性和柔韧物体，特别是帆的表面的点处施加的压力的方法公开(公告)号：US06826968B2
公开(公告)日：2004-12-07
申请号：US09996070
申请日：2001-11-28
IPC分类号： G01L300
CPC分类号： G06F3/044 , B63H9/06 , G01L1/146 , G06F3/0414 , G06F2203/04102
摘要： A device for detecting the pressure exerted at different points of a flexible and/or pliable object that may assume different shapes, includes a plurality of capacitive pressure sensors and at least a system for biasing and reading the capacitance of the sensors. The requirements of flexibility or pliability are satisfied by capacitive pressure sensors formed by two orthogonal sets of parallel or substantially parallel electrodes spaced, at least at each crossing between an electrode of one set and an electrode of the other set, by an elastically compressible dielectric, forming an array of pressure sensing pixel capacitors. The system for biasing and reading the capacitance includes column plate electrode selection circuits and row plate electrode selection circuits and a logic circuit for sequentially scanning the pixel capacitors and outputting pixel values of the pressure for reconstructing a distribution map of the pressure over the area of the array.
摘要翻译： 用于检测施加在可能呈现不同形状的柔性和/或柔韧物体的不同点处的压力的装置包括多个电容式压力传感器和用于偏置和读取传感器的电容的系统。 柔性或柔韧性的要求由通过平行或基本上平行的电极形成的电容式压力传感器来满足，所述平行或基本上平行的电极至少在一组电极和另一组的电极之间的每个交叉处由可弹性压缩的电介质间隔开， 形成压力感测像素电容器阵列。 用于偏置和读取电容的系统包括列板电极选择电路和行板电极选择电路，以及用于顺序扫描像素电容器并输出压力的像素值的逻辑电路，用于重建压力的分布图， 数组。
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公开(公告)号：US07755683B2
公开(公告)日：2010-07-13
申请号：US09994384
申请日：2001-11-26
CPC分类号： G01D5/24
摘要： The method is for reading a capacitive sensor and may be implemented by a circuit for biasing and reading capacitances that includes circuits for selecting a column line and a row line, and a charge amplifier producing an output voltage representing the capacitance of the selected capacitor intercepted by the selected column and row lines. The method includes preliminarily resetting the output voltage of the charge amplifier, connecting all the deselected row and column plates of the array to a reference voltage and connecting a feedback capacitor and the selected capacitor to an inverting input of the amplifier, applying a step voltage on the capacitor that is connected to the inverting input of the amplifier, and reading the output voltage at steady-state.
摘要翻译： 该方法用于读取电容传感器，并且可以由用于偏置和读取电容的电路来实现，该电路包括用于选择列线和行线的电路，以及电荷放大器，其产生表示所选择的电容器的电容被截取的电容 所选列和行行。 该方法包括：对电荷放大器的输出电压进行预先复位，将阵列的所有未选择的列和列板连接到参考电压，并将反馈电容器和所选择的电容器连接到放大器的反相输入端， 连接到放大器的反相输入的电容器，并在稳态下读出输出电压。
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公开(公告)号：US07251991B2
公开(公告)日：2007-08-07
申请号：US10969233
申请日：2004-10-19
IPC分类号： G01M17/02
CPC分类号： G01M17/02
摘要： A measurement technique determines the physical features of a tire such as a determination of the deformation a tire undergoes during use. The measurement technique utilizes a first belt, or first and second belts, in the tire reinforced with a plurality of metallic wires and involves the steps of providing a signal between a first and a second metallic wire associated with the first or first and second belts. The measurement technique determines a real part and an imaginary part of the impedance between the first and second metallic wires, which is proportional to the forces acting on the tire.
摘要翻译： 测量技术确定轮胎的物理特征，例如轮胎在使用过程中变形的确定。 该测量技术利用在多个金属线中增强的轮胎中的第一带或第一和第二带，并且涉及在与第一和第二和第二带相关联的第一和第二金属线之间提供信号的步骤。 测量技术确定第一和第二金属线之间的阻抗的实部和虚部，其与作用在轮胎上的力成比例。
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公开(公告)号：US20050081617A1
公开(公告)日：2005-04-21
申请号：US10969233
申请日：2004-10-19
CPC分类号： G01M17/02
摘要： A measurement technique determines the physical features of a tire such as a determination of the deformation a tire undergoes during use. The measurement technique utilizes a first belt, or first and second belts, in the tire reinforced with a plurality of metallic wires and involves the steps of providing a signal between a first and a second metallic wire associated with the first or first and second belts. The measurement technique determines a real part and an imaginary part of the impedance between the first and second metallic wires, which is proportional to the forces acting on the tire.
摘要翻译： 测量技术确定轮胎的物理特征，例如轮胎在使用过程中变形的确定。 该测量技术利用在多个金属线中增强的轮胎中的第一带或第一和第二带，并且涉及在与第一和第二和第二带相关联的第一和第二金属线之间提供信号的步骤。 测量技术确定第一和第二金属线之间的阻抗的实部和虚部，其与作用在轮胎上的力成比例。
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公开(公告)号：US06731120B2
公开(公告)日：2004-05-04
申请号：US09999065
申请日：2001-10-30
申请人： Marco Tartagni
发明人： Marco Tartagni
IPC分类号： G01R2726
CPC分类号： G01B7/004 , G01B7/023 , G01B7/34 , G06K9/0002
摘要： A distance sensor has a capacitive element in turn having a first plate which is positioned facing a second plate whose distance is to be measured. In the case of fingerprinting, the second plate is defined directly by the skin surface of the finger being printed. The sensor comprises an inverting amplifier, between the input and output of which the capacitive element is connected to form a negative feedback branch. By supplying an electric charge step to the input of the inverting amplifier, a voltage step directly proportional to the distance being measured is obtained at the output.
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公开(公告)号：US06437583B1
公开(公告)日：2002-08-20
申请号：US09614093
申请日：2000-07-11
申请人： Marco Tartagni , Bhusan Gupta , Alan Kramer
发明人： Marco Tartagni , Bhusan Gupta , Alan Kramer
IPC分类号： G01R2726
CPC分类号： G01B7/023 , G01B7/004 , G01B7/287 , G01B7/34 , G06K9/0002
摘要： A distance sensor has a capacitive element in turn having a first capacitor plate which is positioned facing a second capacitor plate whose distance is to be measured. In the case of fingerprinting, the second capacitor plate is defined directly by the skin surface of the finger being printed. The sensor comprises an inverting amplifier, between the input and output of which the capacitive element is connected to form a negative feedback branch. By supplying an electric charge step to the input of the inverting amplifier, a voltage step directly proportional to the distance being measured is obtained at the output.
摘要翻译： 距离传感器具有电容元件，其依次具有第一电容器板，该第一电容器板面对要测量距离的第二电容器板。 在指纹的情况下，第二电容器板由被打印的手指的皮肤表面直接限定。 该传感器包括反相放大器，在其输入和输出之间电容元件连接以形成负反馈支路。 通过向反相放大器的输入端提供电荷步骤，在输出端获得与测量距离成正比的电压阶跃。
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公开(公告)号：US06320394B1
公开(公告)日：2001-11-20
申请号：US09019496
申请日：1998-02-05
申请人： Marco Tartagni
发明人： Marco Tartagni
IPC分类号： G01R2726
CPC分类号： G01B7/004 , G01B7/023 , G01B7/34 , G06K9/0002
摘要： A distance sensor has a capacitive element in turn having a first armature which is positioned facing a second armature whose distance is to be measured. In the case of fingerprinting, the second armature is defined directly by the skin surface of the finger being printed. The sensor comprises an inverting amplifier, between the input and output of which the capacitive element is connected to form a negative feedback branch. By supplying an electric charge step to the input of the inverting amplifier, a voltage step directly proportional to the distance being measured is obtained at the output.
摘要翻译： 距离传感器具有电容元件，其依次具有第一电枢，该第一电枢被定位成面对要测量其距离的第二电枢。 在指纹识别的情况下，第二电枢由被打印的手指的皮肤表面直接限定。 该传感器包括反相放大器，在其输入和输出之间电容元件连接以形成负反馈支路。 通过向反相放大器的输入端提供电荷步骤，在输出端获得与测量距离成正比的电压阶跃。
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