公开(公告)号：US20240125688A1

公开(公告)日：2024-04-18

申请号：US18485415

申请日：2023-10-12

申请人： ADVANTEST CORPORATION

发明人： Yasuharu IMAI ,  Nobuei WASHIZU ,  Kosuke OINUMA

IPC分类号： G01N15/12

CPC分类号： G01N15/1209 ,  G01N2015/1254

摘要： A pore device is used with a measurement device. The pore device includes a pore chip and a chip case which has a chamber partitioned by the pore chip. A measurement terminal group is provided to apply an electric signal from the measurement device to the chamber and output an electric signal generated in the chamber to the measurement device. Interface means is connected to a nonvolatile memory such that the nonvolatile memory is accessible from an outside of the pore device.

公开(公告)号：US09816983B2

公开(公告)日：2017-11-14

申请号：US14603923

申请日：2015-01-23

申请人： SYSMEX CORPORATION

发明人： Daigo Fukuma ,  Takaaki Nagai ,  Masaharu Shibata

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/49 ,  G01N15/14 ,  G01N21/17 ,  G01N27/00 ,  G01N15/06 ,  G01N15/10 ,  G01N15/12 ,  G01N15/00

CPC分类号： G01N33/5094 ,  G01N15/06 ,  G01N15/0656 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/14 ,  G01N15/147 ,  G01N21/17 ,  G01N27/00 ,  G01N33/4915 ,  G01N35/00603 ,  G01N2015/0084 ,  G01N2015/0693 ,  G01N2015/1037 ,  G01N2015/1254

摘要： A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed.

公开(公告)号：US20160139024A1

公开(公告)日：2016-05-19

申请号：US14938711

申请日：2015-11-11

申请人： Agency for Science, Technology and Research

发明人： Seong-Jin Kim

IPC分类号： G01N15/12 ,  G01N33/487 ,  B01L3/00

CPC分类号： G01N15/1227 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0645 ,  G01N15/1056 ,  G01N33/48735 ,  G01N33/48785 ,  G01N2015/1006 ,  G01N2015/1254

摘要： A particle occurrence sensing circuit for microfluidic particle sensing includes a set of particle event indicators, each of which includes: a Coulter counter having a sensing electrode exposable to a fluid within a microfluidic channel and configured for providing a particle sensing signal; an input stage configured for providing an extracted particle sensing signal; and a particle event detector configured for providing a set of particle event occurrence signals. Each of the set of particle event occurrence signals indicates a sensed occurrence of a particle greater than or equal to a given reference particle size during fluid flow through the microfluidic channel to which the sensing electrode is exposed. The particle event detector includes a successive approximation (SA) analog-to-digital converter (ADC) configured for generating a plurality of reference particle size threshold values and successively comparing the extracted particle sensing signal amplitude with reference particle size threshold values.

摘要翻译： 用于微流体粒子感测的粒子发生感测电路包括一组粒子事件指示器，每个粒子事件指示器包括：库尔特计数器，其具有可暴露于微流体通道内的流体并被配置用于提供粒子感测信号的感测电极; 输入级，被配置为提供提取的粒子感测信号; 以及被配置为提供一组粒子事件发生信号的粒子事件检测器。 所述一组粒子事件发生信号中的每一个表示在通过感测电极暴露于的微流体通道的流体流动期间，感测出的大于或等于给定参考粒度的粒子的出现。 粒子事件检测器包括被配置用于产生多个参考粒子大小阈值的逐次逼近（SA）模数转换器（ADC），并且连续地将所提取的粒子感测信号幅度与参考粒子大小阈值进行比较。

公开(公告)号：US20110050200A1

公开(公告)日：2011-03-03

申请号：US12866646

申请日：2009-02-06

申请人： Marco Tartagni ,  Michele Rossi ,  Nicolò Manaresi

发明人： Marco Tartagni ,  Michele Rossi ,  Nicolò Manaresi

IPC分类号： G01N15/12

CPC分类号： G01N15/12 ,  G01N15/1056 ,  G01N15/1218 ,  G01N15/1245 ,  G01N2015/0038 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1254

摘要： The invention relates to an apparatus for counting particles in a fluid comprising a substrate having a first surface; a lid having a second surface facing the first; at least one spacer element interposed between the substrate and the lid so as to maintain the first and second surface spaced from one another; a partition with a plurality of through-openings having nanometric size, the partition being interposed between the spacer element and the lid so as to define at least one first chamber between the partition and the lid and at least one second chamber between the partition and the substrate, the chambers being fluidically connected with one another through at least one of the openings. According to the invention, the substrate has at least one first electrode on the first surface and the lid has a second electrode, each first electrode being configured so as to detect an electric signal associated to the passage of one of said particles through one of the through-openings of the partition. The invention further relates to a corresponding method for counting particles in a fluid.

摘要翻译： 本发明涉及一种用于计数流体中颗粒的装置，包括具有第一表面的基底; 具有面向第一表面的第二表面的盖; 插入在所述基板和所述盖之间的至少一个间隔元件，以便保持所述第一和第二表面彼此间隔开; 具有多个具有纳米尺寸的通孔的分隔件，所述分隔件插入在所述间隔元件和所述盖之间，以便限定所述隔板和所述盖之间的至少一个第一室以及所述分隔件与所述盖之间的至少一个第二室 衬底，腔室通过至少一个开口彼此流体连接。 根据本发明，衬底在第一表面上具有至少一个第一电极，盖具有第二电极，每个第一电极被配置为检测与所述颗粒中的一个通过之一相关的电信号 分区的通孔。 本发明还涉及用于计算流体中颗粒的相应方法。

公开(公告)号：US07579823B1

公开(公告)日：2009-08-25

申请号：US12156605

申请日：2008-06-03

申请人： Harold E. Ayliffe

发明人： Harold E. Ayliffe

IPC分类号： G01N27/00

CPC分类号： G01N15/1056 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N15/1218 ,  G01N2015/1006 ,  G01N2015/1254

摘要： An electrically operated, particle detecting, or characterizing, sensor structured as a thin film multilayer sandwich. Three or more electrodes are deposited onto thin layers of film, and stacked to form the sandwich. A representative stacking arrangement provides a pair of stimulated electrodes spaced apart from an intermediate measurement electrode by insulating layers of thin film. A fluid conducting channel, having an axis perpendicular to the film layers, provides electrolytic electrical communication between the three electrodes. Contact pads, arranged to permit electrical interrogation of the electrodes by electrical circuitry, are desirably arranged for access to electrical interrogation probes from a single side of the sensor. Certain sensors may be included in single-use, disposable cartridges adapted for analysis by an interrogation platform.

摘要翻译： 作为薄膜多层夹层结构的电动，粒子检测或特征传感器。 将三个或更多个电极沉积在薄膜层上，并堆叠形成三明治。 代表性堆叠装置通过薄膜的绝缘层提供与中间测量电极间隔开的一对受激电极。 具有垂直于膜层的轴的流体传导通道在三个电极之间提供电解电气连通。 布置成允许通过电路对电极进行电询问的接触垫理想地布置成用于从传感器的单侧接近电询问探头。 一些传感器可以包括在一次性的一次性盒中，适用于询问平台的分析。

公开(公告)号：US07279883B2

公开(公告)日：2007-10-09

申请号：US10056103

申请日：2002-01-23

申请人： Lydia L. Sohn ,  Omar A. Saleh

发明人： Lydia L. Sohn ,  Omar A. Saleh

IPC分类号： G01N27/00

CPC分类号： B82Y30/00 ,  G01N15/1056 ,  G01N15/1227 ,  G01N2015/1254 ,  G01N2015/149

摘要： A quantitative microchip Coulter counter is provided for use in detecting and measuring particles or macromolecules. The device comprises a conduit, a fluid handling system, and a measurement system. Preferably, the conduit is at least in part formed from an elastomeric material.

摘要翻译： 定量微芯片库尔特计数器用于检测和测量颗粒或大分子。 该装置包括导管，流体处理系统和测量系统。 优选地，导管至少部分地由弹性体材料形成。

公开(公告)号：US20020140414A1

公开(公告)日：2002-10-03

申请号：US10056103

申请日：2002-01-23

发明人： Lydia L. Sohn ,  Omar A. Saleh

IPC分类号： G01N027/00

CPC分类号： B82Y30/00 ,  G01N15/1056 ,  G01N15/1227 ,  G01N2015/1254 ,  G01N2015/149

摘要： A quantitative microchip Coulter counter is provided for use in detecting and measuring particles or macromolecules. The device comprises a conduit, a fluid handling system, and a measurement system. Preferably, the conduit is at least in part formed from an elastomeric material.

摘要翻译： 定量微芯片库尔特计数器用于检测和测量颗粒或大分子。 该装置包括导管，流体处理系统和测量系统。 优选地，导管至少部分地由弹性体材料形成。

公开(公告)号：US5351118A

公开(公告)日：1994-09-27

申请号：US688545

申请日：1991-06-10

申请人： Max Spinell

发明人： Max Spinell

IPC分类号： G01N15/00 ,  G01N1/38 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N21/64 ,  G01N33/49 ,  G01N21/01 ,  G01N21/05

CPC分类号： G01N15/10 ,  G01N15/1404 ,  G01N1/38 ,  G01N2015/1037 ,  G01N2015/1254 ,  G01N2015/1409 ,  G01N2015/1418 ,  G01N21/64 ,  Y10S436/805 ,  Y10S436/806

摘要： An apparatus and a method for analyzing particles suspended in a liquid are described, which particles are of a type or are prepared so as to emit radiation characteristic of the particles when exposed to radiation. Particular fluorescence-photometrical flow cytometry is described in connection with biological cell populations.The apparatus comprises an elongated flow area in the shape of a channel provided in a cuvette comprising a first body member having a planar facial surface and a second body member having a planar facial surface. The first and the second body members are adapted to be moved relative to one another between a first position, in which the planar facial surfaces are in fluid-tight contact with one another, and a second position, in which the planar facial surfaces are spaced apart. At least one of the planar facial surfaces of one of the body members is provided with an elongated groove. In the first position, the first and second body members together define the cuvette in which the elongated flow area is defined by the elongated groove constituting a capillary passage. An inlet for feeding the liquid to the elongated flow area is provided in one of the body members and an outlet for discharging the liquid from the elongated flow area is provided in the very same or in the other body member. At least one of the body members is transparent to light to which the particles are exposed and further transparent to the radiation emitted by the particles. Two electrodes are further described for carrying out an election of particles suspended in the liquid by means of a measurement of the electrical conductivity of the fluid, which particles are of a specific size for subsequent registration of fluorescence when exposed to radiation.

摘要翻译： PCT No.PCT / DK91 / 00120 Sec。 371日期1991年6月10日 102（e）1991年6月10日PCT PCT 1991年5月6日提交PCT公布。 出版物WO91 / 17422 PCT 描述了一种用于分析悬浮在液体中的颗粒的装置和方法，所述装置和方法用于分析悬浮在液体中的颗粒，所述颗粒是暴露于辐射时颗粒的类型或准备以发射颗粒的辐射特征。 结合生物细胞群体描述了特定的荧光光度流式细胞术。 该装置包括设置在比色皿中的通道形状的细长流动区域，其包括具有平坦面部表面的第一主体构件和具有平坦面部表面的第二主体构件。 第一和第二主体构件适于在平面面彼此流体密封的第一位置和第二位置之间相对于彼此移动，在第二位置，平面面部间隔开 分开 身体构件中的一个的平面面中的至少一个设置有细长凹槽。 在第一位置，第一和第二主体部件一起限定了细小流动区域由构成毛细管通道的细长槽限定的比色皿。 用于将液体供给到细长流动区域的入口设置在主体构件中的一个中，并且用于将液体从细长流动区域排出的出口设置在相同或另一个主体构件中。 身体构件中的至少一个对于暴露颗粒的光是透明的，并且对于由颗粒发射的辐射更透明。 进一步描述了两个电极，用于通过流体的电导率的测量来进行悬浮在液体中的颗粒的选择，该颗粒具有特定尺寸，用于当暴露于辐射时随后的荧光配准。

公开(公告)号：US4527114A

公开(公告)日：1985-07-02

申请号：US352438

申请日：1982-02-25

申请人： Wallace H. Coulter

发明人： Wallace H. Coulter

IPC分类号： G01N15/12 ,  G01N27/00

CPC分类号： G01N15/12 ,  G01N2015/1254

摘要： A particle analyzer apparatus comprising a flow cell having a flow chamber wherein a flow of liquid suspension, having individual particles entrained therein, proceeds along a predetermined path; a pair of electrodes are disposed on opposed sides of the predetermined path, one of the electrodes having an end with a width parallel to the predetermined path that is less than the length of a given particle, the end of the electrode being positioned in close proximity to the predetermined path; energizing source for providing an electrical field between the pair of electrodes that traverses the predetermined path; and a particle pulse detector for detecting particle pulses caused by the particles passing through the electric field.

摘要翻译： 一种颗粒分析仪装置，包括具有流动室的流动池，其中夹带有单个颗粒的液体悬浮液流沿预定路径进行; 一对电极设置在预定路径的相对侧上，其中一个电极具有平行于预定路径的宽度小于给定粒子的长度的端部，电极的端部紧邻 到预定路径; 激励源，用于在穿过所述预定路径的所述一对电极之间提供电场; 以及用于检测由通过电场的粒子引起的粒子脉冲的粒子脉冲检测器。

公开(公告)号：US11668639B2

公开(公告)日：2023-06-06

申请号：US17228656

申请日：2021-04-12

申请人： Taiwan Semiconductor Manufacturing Company, Ltd.

发明人： En-Tian Lin ,  Chwen Yu ,  Mei Lee ,  Shu-Yu Hsu

IPC分类号： G01R1/04 ,  G01R1/067 ,  G01R1/073 ,  G01N15/10 ,  G01N15/12 ,  G01N27/00 ,  G01N33/28 ,  G01N21/00 ,  H01L21/67 ,  G01N15/00

CPC分类号： G01N15/1227 ,  H01L21/67023 ,  G01N2015/0038 ,  G01N2015/1254

摘要： A method for processing a substrate by using fluid flowing through a particle detector is provided. The particle detector is utilized to detect nano-particles contained in fluid. The particle detector includes a substrate and a pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.