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    Linear Variable Optical Filter Systems for Flow Cytometry and Methods for Using the Same
    1.
    发明公开
    Linear Variable Optical Filter Systems for Flow Cytometry and Methods for Using the Same 审中-公开

    公开(公告)号：US20230384204A1

    公开(公告)日：2023-11-30

    申请号：US18142767

    申请日：2023-05-03

    Applicant: Becton, Dickinson and Company

    Inventor： Geoffrey Osborne

    IPC: G01N15/14 ,  G02B5/28 ,  G02B5/20 ,  G01J1/58

    CPC classification number: G01N15/1434 ,  G02B5/288 ,  G02B5/203 ,  G01J1/58 ,  G01N2015/1037

    Abstract: Aspects of the present disclosure include systems for detecting light from a particle in a flow stream by spectral discrimination. Light detection systems according to certain embodiments include a wavelength separator component configured to propagate light between a first set of linear variable optical filters and a second set of linear variable optical filters where each set of linear variable optical filters is configured to pass light having predetermined sub-spectral ranges and a plurality of photodetectors positioned to detect light from each sub-spectral range across the linear variable optical filters. Systems having a light source for irradiating a particle in a flow stream and a photodetector modulator component for binning data signals generated in a plurality of photodetector channels of the light detection system are also described. Methods for detecting light with the subject systems and kits having one or more components for detecting light according to the subject methods are also provided.

    ANALYZING SYSTEM AND ANALYZING APPARATUS
    6.
    发明申请
    ANALYZING SYSTEM AND ANALYZING APPARATUS 审中-公开
    分析系统和分析装置

    公开(公告)号：US20160109353A1

    公开(公告)日：2016-04-21

    申请号：US14885432

    申请日：2015-10-16

    Applicant: NIHON KOHDEN CORPORATION

    Inventor： Yutaka NAGAI

    IPC: G01N15/14 ,  G01N27/06

    CPC classification number: G01N15/1434 ,  G01N15/1031 ,  G01N15/1468 ,  G01N27/06 ,  G01N2015/1037

    Abstract: An analyzing system includes an imaging cytometer having a first imaging section configured to perform an imaging of particles contained in an analyte sample to generate images, the imaging cytometer being configured to analyze the images generated by the first imaging section, and a blood cell analyzing apparatus configured to analyze particles contained in the analyte sample by at least one of an electrical resistance method and an optical analyzing method. One of the imaging cytometer and the blood cell analyzing apparatus has an analyzing section configured to produce a report of an analysis of the analyte sample based on particle information acquired by the imaging cytometer and particle information acquired by the blood cell analyzing apparatus.

    Abstract translation: 分析系统包括具有第一成像部分的成像细胞计数器，所述第一成像部分被配置为对分析物样品中包含的颗粒进行成像以产生图像，所述成像细胞计数器被配置为分析由第一成像部分生成的图像，以及血细胞分析装置 被配置为通过电阻方法和光学分析方法中的至少一种来分析包含在分析物样品中的颗粒。 成像细胞仪和血细胞分析装置中的一个具有分析部，其被配置为基于由成像细胞仪获取的粒子信息和由血细胞分析装置获取的粒子信息来生成分析物样品的分析报告。

    MICROPARTICLE ANALYSIS APPARATUS AND MICROPARTICLE ANALYSIS SYSTEM
    8.
    发明申请
    MICROPARTICLE ANALYSIS APPARATUS AND MICROPARTICLE ANALYSIS SYSTEM 有权
    微波分析仪器和微波分析系统

    公开(公告)号：US20150377763A1

    公开(公告)日：2015-12-31

    申请号：US14763980

    申请日：2013-12-26

    Applicant: SONY CORPORATION

    Inventor： Marcaurele Brun ,  Kazumasa Sato ,  Shinji Omori ,  Yoichi Katsumoto

    IPC: G01N15/10 ,  G01N33/487 ,  G01N27/22

    CPC classification number: G01N15/1031 ,  G01N15/1218 ,  G01N27/221 ,  G01N33/48728 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1081 ,  G01N2015/1087 ,  G01N2015/1254 ,  G01N2015/129

    Abstract: There is provided a microparticle analysis apparatus including a sample channel configured to receive liquid containing a plurality of microparticles, a first pair of electrodes configured to form an alternating electric field in at least a part of the sample channel, a measuring part configured to measure impedance between the first pair of electrodes, an analyzing part configured to calculate property values of the microparticles from the impedance measured in the measuring part, and a determining part configured to determine whether data of the impedance measured in the measuring part is derived from the microparticles.

    Abstract translation: 提供了一种微粒分析装置，其包括被配置为接收含有多个微粒的液体的样品通道，第一对电极构造成在至少一部分样品通道中形成交变电场;测量部件，被配置为测量阻抗 在第一对电极之间，分析部件被配置为根据在测量部件中测量的阻抗计算微粒的特性值，以及确定部件，被配置为确定在测量部件中测量的阻抗的数据是否从微粒导出。

    Reusable thin film particle sensor
    9.
    发明授权
    Reusable thin film particle sensor 失效
    可重复使用的薄膜颗粒传感器

    公开(公告)号：US08616048B2

    公开(公告)日：2013-12-31

    申请号：US12985536

    申请日：2011-01-06

    Applicant: Harold E. Ayliffe

    Inventor： Harold E. Ayliffe

    IPC: G01N15/06 ,  G01N27/00

    CPC classification number: G01N15/12 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2300/0645 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0487 ,  G01N15/1056 ,  G01N15/1463 ,  G01N33/49 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1087

    Abstract: A microfluidic sensor formed by stacking a plurality of substantially non-electrically conductive layers, typically formed from thin polymer films. Certain layers may carry patterned electrodes that are arranged to permit their connection to an electrical interrogation circuit. Electrodes may be disposed in a 3-dimensional array in the sensor. A fluid path through the sensor includes an orifice sized to promote single-file travel of particles. The orifice may be defined by a tunnel passing through at least one layer. Particles entrained in an electrolytic carrier fluid may be detected, or otherwise characterized, by interrogation circuitry connected to certain embodiments of the sensor. Sensors generally include portions of a fluid path disposed parallel to the layers. Sensors may operate under the Coulter principle, and/or Stokes' shift phenomena. In certain embodiments, the sensor may be carried by a cartridge, which is adapted to couple with an interrogation platform. In any case, coupling desirably places the sensor in-circuit with operable interrogation structure, as well as with a fluid-flow control device. Structure included in a cartridge may provide fluid sample loading, routing, and storage capabilities.

    Abstract translation: 通过层叠通常由薄聚合物膜形成的多个基本上非导电层形成的微流体传感器。 某些层可以携带被布置成允许它们连接到电询问电路的图案化电极。 电极可以设置在传感器中的3维阵列中。 通过传感器的流体路径包括尺寸适于促进颗粒单文件行进的孔口。 孔可以由穿过至少一层的隧道限定。 携带在电解载体流体中的颗粒可以通过连接到传感器的某些实施例的询问电路来检测或以其它方式表征。 传感器通常包括平行于层布置的流体路径的部分。 传感器可以在库尔特原理和/或斯托克斯转移现象下运行。 在某些实施例中，传感器可以由适于与询问平台耦合的卡盒携带。 在任何情况下，耦合期望将传感器在线地具有可操作的询问结构以及流体流动控制装置。 盒中包含的结构可提供流体样品加载，路由和存储功能。

    FLUORESCENCE FLOW CYTOMETRY
    10.
    发明申请
    FLUORESCENCE FLOW CYTOMETRY 有权
    荧光细胞计数

    公开(公告)号：US20130327957A1

    公开(公告)日：2013-12-12

    申请号：US13492805

    申请日：2012-06-09

    Applicant: Harold E. Ayliffe

    Inventor： Harold E. Ayliffe

    IPC: G01N21/64

    CPC classification number: G01N21/64 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1037

    Abstract: A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette.

    Abstract translation: 包括激光，分度结构，调整结构和传感器结构的流式细胞仪。 通常，细胞计数器使用可拆卸的微流控盒，其安装在由分度结构执行的第一位置。 调整结构改变了盒的询问孔与激光束之间的相对位置。 来自传感器结构的反馈用于优化激光通过询问孔的传播，以减少（并希望消除）由光束撞击到盒上引起的自发荧光。

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