公开(公告)号：US09849247B2

公开(公告)日：2017-12-26

申请号：US13261383

申请日：2011-01-31

申请人： Margaret Taylor ,  James Bates ,  Roman Tunkel ,  Jay Butterbrodt ,  Gary Searle ,  Joshua Horvath ,  Keith Knapp, II ,  Edward Gillen

发明人： Margaret Taylor ,  James Bates ,  Roman Tunkel ,  Jay Butterbrodt ,  Gary Searle ,  Joshua Horvath ,  Keith Knapp, II ,  Edward Gillen

IPC分类号： A61M5/24 ,  A61M5/32 ,  A61M5/42 ,  A61M5/00 ,  A61M5/20

CPC分类号： A61M5/2425 ,  A61M5/2459 ,  A61M5/3287 ,  A61M5/425 ,  A61M2005/005 ,  A61M2005/206

摘要： A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

公开(公告)号：US20130006216A1

公开(公告)日：2013-01-03

申请号：US13261383

申请日：2011-01-31

申请人： Margaret Taylor ,  James Bates ,  Roman Tunkel ,  Jay Butterbrodt ,  Gary Searle ,  Joshua Horvath ,  Keith Knapp, II ,  Edward Gillen

发明人： Margaret Taylor ,  James Bates ,  Roman Tunkel ,  Jay Butterbrodt ,  Gary Searle ,  Joshua Horvath ,  Keith Knapp, II ,  Edward Gillen

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/32

CPC分类号： A61M5/2425 ,  A61M5/2459 ,  A61M5/3287 ,  A61M5/425 ,  A61M2005/005 ,  A61M2005/206

摘要： A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

摘要翻译： 用于施用低剂量药物的药物递送装置（100）包括设置在壳体（111）中的壳体（111）和药物储存器（101）。 针（135）连接到药物储存器（101）。 压力施加构件（113）可移动地连接到壳体（111）并且可在第一和第二位置之间移动。 压力施加构件（113）在第一位置不对药物储存器（101）施加压力，并且在第二位置向药物储存器（101）施加压力以分配存储在药物储存器（101）中的药物。 还公开了施用低剂量胰岛素以模拟胰腺的第一阶段胰岛素反应的方法。

公开(公告)号：US20120041383A1

公开(公告)日：2012-02-16

申请号：US13206405

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

IPC分类号： A61M5/34 ,  A61M5/31 ,  A61M5/32

CPC分类号： A61M5/008 ,  A61M2005/004

摘要： An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.

摘要翻译： 公开了一种用于存储和更换用于具有药物容器的药物输送装置的针的装置，其包括用于将装置与药物输送装置连接的固定支架，可沿着迂回路径移位并连接可移动地设置在其上的多个针的针保持器 以及用于引导针保持器的位移的引导构件，所述引导构件围绕固定座设置。 该装置还包括可旋转地设置在固定安装件周围的用户界面，并且具有至少一个内部接合结构，用于沿着迂回路径移动针保持器。

公开(公告)号：US09427514B2

公开(公告)日：2016-08-30

申请号：US13206438

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

IPC分类号： A61M5/32 ,  A61M5/00

CPC分类号： A61M5/002 ,  A61B5/150389 ,  A61M5/3205 ,  A61M5/3243 ,  A61M5/3298 ,  A61M2005/004 ,  A61M2005/312

摘要： An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle.

摘要翻译： 公开了一种用于存储和更换用于与药物输送装置连接的针的装置，包括内部壳体，设置在内部壳体内的储存器和设置在内部壳体内的针保持器，用于将药物输送物的药物容器流体连接 装置与水库。 该装置还包括可移动地设置在针保持器上的多个患者针和可围绕内壳可移动地设置的外壳，并且提供用户界面以单独选择多个患者针中的一个，将所选择的针与储存器连接， 将所选择的针暴露在注射装置外部，并存储所选择的针。

公开(公告)号：US09107988B2

公开(公告)日：2015-08-18

申请号：US13206405

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

IPC分类号： A61M5/00

CPC分类号： A61M5/008 ,  A61M2005/004

摘要： An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.

摘要翻译： 公开了一种用于存储和更换用于具有药物容器的药物输送装置的针的装置，其包括用于将装置与药物输送装置连接的固定支架，可沿着迂回路径移动并连接可移动地设置在其上的多个针的针保持器 以及用于引导针保持器的位移的引导构件，所述引导构件围绕固定座设置。 该装置还包括一个可旋转地设置在固定安装件周围的用户界面，并具有至少一个用于沿着迂回路径移动针座的内部接合结构。

公开(公告)号：US20120041385A1

公开(公告)日：2012-02-16

申请号：US13206469

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  Margaret Taylor ,  James Bates

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  Margaret Taylor ,  James Bates

IPC分类号： A61M5/32

CPC分类号： A61M5/002 ,  A61M5/34 ,  A61M5/343 ,  A61M2005/004

摘要： An attachable needle storage device is provided with a main body and a rotatable sleeve and a plurality of new needles stored within the sleeve, a leaf spring to direct each needle into a circumferential position of the pen body when rotated, and a ramp to move the needle into an axial position of the pen body when retracted or pulled rearward by the user. The attachable needle storage device is configured to attach to a pen device in a manner substantially the same as a conventional needle hub. In doing so, the rotation of the sleeve can be used to rotate a new needle onto a shuttle, and the retraction of the device can be used to cause a ramp to engage the needle and needle hub, moving the needle toward the axial position of the pen body and the septum. Once under the septum, the user continues pulling the device rearward, such that the needle is then moved rearward, pierces the septum of the medicament cartridge and exposes the distal end of the needle for injection. After use, a needle shield is used to unlock a compressed spring, which is configured to pull the needle from the septum, and return the device to the transport state, after which the previous steps can be repeated.

摘要翻译： 可附接的针存储装置设置有主体和可旋转的套筒以及存储在套筒内的多个新针，一个板簧，用于将每个针定位成旋转时的笔体周向位置，并且使斜坡移动 当用户收回或向后拉时，针头进入笔体的轴向位置。 可连接针存储装置被配置为以与常规针毂基本相同的方式附接到笔式装置。 在这样做时，套筒的旋转可以用于将新的针旋转到梭子上，并且装置的缩回可以用于引起斜面接合针和针座，使针朝着轴向位置移动 笔体和隔膜。 一旦在隔膜下方，用户继续向后拉动装置，使得针随后向后移动，刺穿药剂盒的隔膜并暴露注射针的远端。 使用后，使用针护罩来解锁压缩弹簧，压缩弹簧被配置为从隔膜拉动针头，并将装置返回到运输状态，之后可以重复前述步骤。

公开(公告)号：US20120041373A1

公开(公告)日：2012-02-16

申请号：US13206438

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  James Bates ,  Margaret Taylor ,  Robert Banik

IPC分类号： A61M5/32

CPC分类号： A61M5/002 ,  A61B5/150389 ,  A61M5/3205 ,  A61M5/3243 ,  A61M5/3298 ,  A61M2005/004 ,  A61M2005/312

摘要： An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle.

摘要翻译： 公开了一种用于存储和更换用于与药物输送装置连接的针的装置，包括内部壳体，设置在内部壳体内的储存器和设置在内部壳体内的针保持器，用于将药物输送物的药物容器流体连接 装置与水库。 该装置还包括可移动地设置在针保持器上的多个患者针和可围绕内壳可移动地设置的外壳，并且提供用户界面以单独选择多个患者针中的一个，将所选择的针与储存器连接， 将所选择的针暴露在注射装置外部，并存储所选择的针。

公开(公告)号：US20090131848A1

公开(公告)日：2009-05-21

申请号：US11941150

申请日：2007-11-16

申请人： Margaret Taylor

发明人： Margaret Taylor

IPC分类号： A61M1/00 ,  A61F9/01

CPC分类号： A61F9/00781

摘要： A method for implanting a transcorneal implant having a cap, a foot, and a body connecting the cap and the foot, the body having a lesser circumference than either the cap or the foot, the method including the operations: creating a first corneal incision to create a tunnel, such that the a far end of the first incision enters the anterior chamber; creating a second corneal incision opening a roof of the tunnel to an end point past the far end of the first incision and creating flaps; guiding the implant to the end point, so that the foot of the implant is under the flaps; rotating the implant until the foot is entirely within the anterior chamber; and rotating the implant back to a neutral position, such that a portion of the foot is beneath a floor of the tunnel.

摘要翻译： 一种用于植入具有帽，脚和连接帽和脚的身体的经睾丸植入物的方法，所述身体具有比帽或脚更小的圆周，所述方法包括以下操作：产生第一角膜切口至 创建隧道，使得第一切口的远端进入前房; 创建第二角膜切口，将隧道的屋顶打开到通过第一切口的远端的终点并产生瓣; 将植入物引导到终点，使得植入物的脚在襟翼下方; 旋转植入物直到足部完全在前房内; 以及将所述植入物旋转回到中立位置，使得所述脚的一部分在所述隧道的地板下方。

公开(公告)号：US08876780B2

公开(公告)日：2014-11-04

申请号：US13206469

申请日：2011-08-09

申请人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  Margaret Taylor ,  James S. Bates

发明人： Michel Bruehwiler ,  Cole Constantineau ,  Ryan Schoonmaker ,  Margaret Taylor ,  James S. Bates

IPC分类号： A61M5/32 ,  A61M5/34 ,  A61M5/00

CPC分类号： A61M5/002 ,  A61M5/34 ,  A61M5/343 ,  A61M2005/004

摘要： An attachable needle storage device is provided with a main body and a rotatable sleeve and a plurality of new needles stored within the sleeve, a leaf spring to direct each needle into a circumferential position of the pen body when rotated, and a ramp to move the needle into an axial position of the pen body when retracted or pulled rearward by the user. The attachable needle storage device is configured to attach to a pen device in a manner substantially the same as a conventional needle hub. In doing so, the rotation of the sleeve can be used to rotate a new needle onto a shuttle, and the retraction of the device can be used to cause a ramp to engage the needle and needle hub, moving the needle toward the axial position of the pen body and the septum. Once under the septum, the user continues pulling the device rearward, such that the needle is then moved rearward, pierces the septum of the medicament cartridge and exposes the distal end of the needle for injection. After use, a needle shield is used to unlock a compressed spring, which is configured to pull the needle from the septum, and return the device to the transport state, after which the previous steps can be repeated.

摘要翻译： 可附接的针存储装置设置有主体和可旋转的套筒以及存储在套筒内的多个新的针，一个板簧，用于在转动时将每个针引导到笔体的圆周位置， 当用户收回或向后拉时，针头进入笔体的轴向位置。 可连接针存储装置被配置为以与常规针毂基本相同的方式附接到笔式装置。 在这样做时，套筒的旋转可以用于将新的针旋转到梭子上，并且装置的缩回可以用于引起斜面接合针和针座，使针朝着轴向位置移动 笔体和隔膜。 一旦在隔膜下方，用户继续向后拉动装置，使得针随后向后移动，刺穿药剂盒的隔膜并暴露注射针的远端。 使用后，使用针护罩来解锁压缩弹簧，压缩弹簧被配置为从隔膜拉动针头，并将装置返回到运输状态，之后可以重复前述步骤。

公开(公告)号：US08247391B2

公开(公告)日：2012-08-21

申请号：US10483313

申请日：2002-07-10

申请人： Margaret Taylor

发明人： Margaret Taylor

IPC分类号： A61K31/721

CPC分类号： G01N33/559 ,  A61K9/0014 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  G01N33/54313 ,  G01N33/548

摘要： The present invention relates to a gel composition, comprising first and second gel-forming moieties which bind reversibly to one another to form a gel. The binding of the moieties is sensitive to the level of an analyte, and either or both of the gel-forming moieties are attached to cross-linked particulate entities such that the interstices between the entities allow gel-sol and sol-gel transformation, and yet are not so small that the analyte cannot diffuse therethrough. The invention also provides drug delivery systems and sensors for detecting an analyte utilizing such a gel.

摘要翻译： 本发明涉及一种凝胶组合物，其包含第一和第二凝胶形成部分，其彼此可逆地结合以形成凝胶。 部分的结合对分析物的水平敏感，并且凝胶形成部分中的任一个或两者连接到交联的颗粒实体，使得实体之间的间隙允许凝胶溶胶和溶胶 - 凝胶转化，以及 但没有那么小，使得分析物不能通过其扩散。 本发明还提供用于使用这种凝胶检测分析物的药物递送系统和传感器。